GREMLIN Database
DUF4293 - Domain of unknown function (DUF4293)
PFAM: PF14126 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 154 (151)
Sequences: 5918 (4809)
Seq/√Len: 391.3
META: 0.908

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_Y140_G3.1331.00
82_I138_N2.7431.00
85_C138_N2.5411.00
78_R148_V2.5351.00
74_L80_L2.3461.00
142_K146_K2.2761.00
88_N134_L2.2641.00
16_A130_A2.2511.00
97_G101_Y2.1801.00
9_L85_C2.1641.00
85_C141_I2.1041.00
80_L83_R2.0941.00
145_E149_K2.0671.00
9_L141_I2.0591.00
14_I18_L2.0311.00
77_N80_L2.0081.00
145_E148_V2.0011.00
12_A68_S1.9551.00
85_C134_L1.9251.00
12_A134_L1.8941.00
68_S134_L1.8851.00
149_K152_D1.8701.00
78_R145_E1.8281.00
70_I74_L1.8191.00
79_K83_R1.7791.00
71_T84_L1.7721.00
26_S121_G1.7601.00
13_A68_S1.6191.00
71_T85_C1.6061.00
68_S88_N1.6041.00
6_T72_I1.5291.00
13_A17_G1.5231.00
136_L140_G1.4781.00
147_L150_S1.4731.00
13_A69_L1.4681.00
15_L126_L1.4661.00
92_N134_L1.4331.00
92_N130_A1.4311.00
8_Y136_L1.4231.00
17_G65_A1.4191.00
82_I142_K1.4031.00
12_A130_A1.4021.00
71_T88_N1.3781.00
89_I134_L1.3631.00
55_W59_I1.3571.00
138_N142_K1.3551.00
13_A65_A1.3541.00
4_I7_L1.3391.00
18_L22_F1.3391.00
89_I131_I1.3151.00
86_R138_N1.3011.00
58_L62_I1.2941.00
7_L11_L1.2921.00
83_R86_R1.2791.00
16_A64_S1.2781.00
93_L131_I1.2561.00
140_G143_K1.2441.00
79_K145_E1.2411.00
38_A41_L1.2301.00
112_G115_F1.1851.00
61_T95_L1.1681.00
12_A88_N1.1641.00
9_L137_A1.1441.00
106_L109_N1.1431.00
74_L84_L1.1401.00
139_R142_K1.0871.00
94_G98_L1.0851.00
1_I6_T1.0701.00
92_N131_I1.0561.00
146_K150_S1.0521.00
66_L70_I1.0441.00
1_I73_F1.0441.00
96_L128_L1.0441.00
4_I143_K1.0331.00
83_R87_L1.0291.00
4_I8_Y1.0211.00
82_I86_R1.0121.00
125_F129_I1.0021.00
80_L84_L0.9891.00
106_L110_L0.9861.00
64_S92_N0.9811.00
34_Y38_A0.9791.00
104_L108_L0.9731.00
67_L84_L0.9711.00
10_L72_I0.9671.00
82_I140_G0.9661.00
9_L68_S0.9471.00
115_F118_G0.9421.00
16_A65_A0.9421.00
39_L42_S0.9321.00
11_L133_L0.9251.00
13_A72_I0.9191.00
16_A92_N0.9111.00
64_S88_N0.9101.00
122_I126_L0.9061.00
64_S95_L0.9041.00
85_C88_N0.9031.00
17_G21_F0.9011.00
151_A154_L0.9011.00
104_L107_S0.8891.00
22_F123_G0.8831.00
107_S110_L0.8821.00
25_A118_G0.8811.00
11_L15_L0.8771.00
29_G32_G0.8761.00
37_Y40_G0.8721.00
37_Y42_S0.8701.00
34_Y37_Y0.8651.00
65_A69_L0.8451.00
64_S68_S0.8361.00
4_I140_G0.8351.00
9_L71_T0.8201.00
137_A141_I0.8081.00
89_I135_F0.8051.00
82_I148_V0.8011.00
103_L106_L0.7981.00
86_R90_L0.7941.00
6_T10_L0.7911.00
120_Y125_F0.7911.00
68_S71_T0.7861.00
1_I10_L0.7741.00
78_R82_I0.7651.00
111_S114_T0.7621.00
36_F40_G0.7581.00
78_R141_I0.7561.00
53_S56_P0.7511.00
10_L14_I0.7511.00
97_G100_F0.7411.00
9_L72_I0.7401.00
37_Y41_L0.7361.00
82_I145_E0.7351.00
86_R142_K0.7281.00
67_L88_N0.7221.00
133_L136_L0.7171.00
100_F104_L0.7161.00
69_L73_F0.7101.00
95_L99_F0.7071.00
19_L61_T0.7041.00
10_L13_A0.7041.00
12_A133_L0.7011.00
35_T38_A0.6981.00
87_L90_L0.6961.00
62_I66_L0.6951.00
55_W58_L0.6920.99
105_F108_L0.6890.99
36_F39_L0.6880.99
51_A54_T0.6850.99
127_P130_A0.6830.99
15_L129_I0.6800.99
2_Q5_Q0.6730.99
18_L126_L0.6710.99
79_K82_I0.6690.99
108_L112_G0.6670.99
103_L110_L0.6660.99
107_S111_S0.6640.99
15_L133_L0.6630.99
34_Y40_G0.6610.99
64_S91_L0.6600.99
134_L138_N0.6580.99
10_L69_L0.6570.99
104_L110_L0.6570.99
19_L99_F0.6550.99
109_N112_G0.6480.99
60_L98_L0.6440.99
135_F139_R0.6420.99
142_K145_E0.6360.99
18_L21_F0.6350.99
71_T74_L0.6340.99
65_A68_S0.6300.99
13_A73_F0.6280.99
39_L58_L0.6280.99
132_I136_L0.6260.99
53_S58_L0.6230.99
79_K142_K0.6190.99
129_I133_L0.6190.99
82_I85_C0.6180.99
36_F41_L0.6170.99
34_Y41_L0.6150.99
54_T58_L0.6140.99
88_N92_N0.6130.99
12_A89_I0.6100.99
28_T31_D0.6100.99
49_V53_S0.6100.99
89_I138_N0.6080.99
20_F58_L0.6060.99
7_L14_I0.6020.99
74_L77_N0.6020.99
139_R143_K0.6010.99
104_L109_N0.5980.99
23_P26_S0.5970.99
111_S115_F0.5940.98
19_L127_P0.5940.98
23_P123_G0.5910.98
82_I146_K0.5890.98
92_N96_L0.5780.98
147_L151_A0.5760.98
19_L123_G0.5730.98
107_S112_G0.5710.98
16_A68_S0.5660.98
29_G33_T0.5650.98
15_L130_A0.5630.98
89_I92_N0.5520.98
77_N153_R0.5480.97
44_A48_V0.5440.97
27_F30_G0.5440.97
35_T40_G0.5400.97
139_R146_K0.5360.97
92_N95_L0.5340.97
88_N91_L0.5340.97
120_Y124_A0.5320.97
148_V151_A0.5290.97
16_A61_T0.5280.97
98_L101_Y0.5280.97
121_G125_F0.5280.97
71_T75_Y0.5260.97
130_A134_L0.5240.97
20_F62_I0.5230.97
104_L113_E0.5230.97
33_T41_L0.5210.97
136_L139_R0.5110.96
54_T57_L0.5110.96
122_I125_F0.5100.96
119_E122_I0.5060.96
86_R96_L0.5060.96
67_L71_T0.5010.96
30_G33_T0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.461 6.5 0.936 Contact Map
4i0uA 4 0.4481 6.1 0.936 Contact Map
1iijA 1 0.2273 4 0.942 Contact Map
2l2tA 2 0.2727 3.8 0.942 Contact Map
2jwaA 2 0.2857 3.8 0.942 Contact Map
3rkoN 1 0.6688 3.7 0.943 Contact Map
1jb0I 1 0.2208 3.4 0.943 Contact Map
4tllB 2 0.3636 2.9 0.946 Contact Map
2k9pA 1 0.5195 2.9 0.946 Contact Map
2hjdA 2 0.2532 2.7 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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