GREMLIN Database
DUF4291 - Domain of unknown function (DUF4291)
PFAM: PF14124 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 180 (179)
Sequences: 2192 (1654)
Seq/√Len: 123.6
META: 0.713

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_S66_V3.3931.00
117_D121_A3.3801.00
56_G60_K3.3061.00
23_D65_R3.0271.00
166_D169_E2.6501.00
78_W139_R2.6111.00
12_V70_R2.5591.00
42_T137_L2.5571.00
159_R163_R2.5091.00
22_A65_R2.4321.00
75_G144_W2.4031.00
20_A35_P2.3901.00
70_R147_S2.3501.00
139_R143_E2.3391.00
73_R77_E2.3091.00
96_R100_K2.3061.00
10_T146_V2.2991.00
38_F141_V2.2791.00
18_R62_G2.0701.00
132_L136_A2.0471.00
32_G35_P2.0311.00
7_D70_R1.9691.00
78_W82_H1.8941.00
58_G66_V1.8931.00
95_S98_E1.8271.00
69_I148_I1.7811.00
162_V167_L1.7701.00
38_F142_D1.7641.00
68_A151_I1.7561.00
58_G152_T1.7291.00
85_L92_V1.7081.00
22_A26_V1.7041.00
138_R142_D1.6951.00
23_D27_A1.6821.00
24_P28_H1.6801.00
115_E127_A1.6771.00
156_R159_R1.6261.00
24_P30_R1.6201.00
19_P23_D1.6111.00
85_L93_Y1.5611.00
77_E180_Y1.5581.00
72_T75_G1.5141.00
52_M155_V1.5001.00
69_I140_Y1.4731.00
83_A110_V1.4731.00
69_I145_I1.4521.00
30_R145_I1.4361.00
30_R142_D1.4311.00
100_K103_L1.4011.00
151_I155_V1.3981.00
94_A98_E1.3941.00
72_T146_V1.3031.00
151_I154_F1.3011.00
76_F130_L1.2901.00
85_L89_D1.2801.00
24_P32_G1.2711.00
6_Y178_R1.2651.00
26_V151_I1.2631.00
107_P135_E1.2591.00
79_A144_W1.2551.00
66_V152_T1.2551.00
93_Y102_A1.2461.00
19_P65_R1.2350.99
145_I148_I1.2300.99
28_H32_G1.2120.99
162_V166_D1.2040.99
38_F138_R1.1870.99
19_P64_E1.1820.99
135_E138_R1.1740.99
42_T141_V1.1730.99
159_R162_V1.1520.99
17_Y36_F1.1340.99
49_L52_M1.1340.99
65_R152_T1.1320.99
47_S116_R1.1160.99
59_T159_R1.1120.99
101_R105_R1.1110.99
31_F140_Y1.1100.99
115_E125_R1.0830.99
88_F99_W1.0760.99
5_Q12_V1.0730.98
89_D92_V1.0500.98
23_D26_V1.0430.98
59_T156_R1.0410.98
98_E101_R1.0270.98
78_W136_A1.0260.98
135_E139_R1.0220.98
12_V68_A1.0160.98
84_V106_S1.0140.98
117_D123_L1.0130.98
160_A163_R1.0070.98
88_F93_Y1.0050.98
86_S109_R0.9850.97
6_Y73_R0.9700.97
49_L57_W0.9640.97
38_F75_G0.9630.97
107_P133_R0.9590.97
42_T132_L0.9500.97
158_Q170_A0.9430.97
100_K104_A0.9340.96
161_L169_E0.9310.96
119_R167_L0.9170.96
41_M109_R0.9070.96
79_A130_L0.9020.96
152_T156_R0.9010.96
75_G79_A0.9000.96
10_T70_R0.8980.95
106_S133_R0.8960.95
3_R115_E0.8890.95
26_V65_R0.8850.95
53_Y120_G0.8820.95
18_R35_P0.8750.95
48_F155_V0.8740.95
79_A136_A0.8730.95
56_G59_T0.8720.95
110_V130_L0.8680.95
29_G148_I0.8660.94
139_R144_W0.8620.94
161_L166_D0.8590.94
120_G155_V0.8590.94
107_P136_A0.8580.94
31_F69_I0.8490.94
118_P174_L0.8390.94
7_D10_T0.8360.93
160_A164_A0.8340.93
82_H136_A0.8330.93
52_M57_W0.8300.93
88_F95_S0.8220.93
114_P126_R0.8190.93
98_E102_A0.8190.93
53_Y122_P0.8090.92
58_G156_R0.8080.92
36_F140_Y0.7980.92
82_H135_E0.7970.92
20_A62_G0.7950.92
78_W81_A0.7920.91
19_P26_V0.7900.91
26_V29_G0.7860.91
102_A106_S0.7840.91
169_E172_A0.7710.90
51_M109_R0.7700.90
58_G65_R0.7640.90
9_D74_E0.7630.90
75_G141_V0.7560.89
84_V102_A0.7550.89
73_R180_Y0.7440.89
31_F34_P0.7390.88
91_G94_A0.7340.88
93_Y98_E0.7330.88
18_R37_S0.7270.88
84_V103_L0.7260.87
108_V132_L0.7230.87
89_D94_A0.7230.87
53_Y116_R0.7230.87
101_R104_A0.7210.87
65_R150_D0.7160.87
103_L133_R0.7110.86
82_H107_P0.7040.86
118_P158_Q0.7020.86
157_E173_L0.7000.85
154_F158_Q0.6990.85
153_P157_E0.6950.85
86_S106_S0.6950.85
59_T66_V0.6950.85
68_A149_E0.6900.85
107_P134_G0.6880.84
61_E64_E0.6840.84
55_S59_T0.6780.84
76_F128_I0.6770.84
137_L141_V0.6750.83
138_R143_E0.6650.82
88_F96_R0.6640.82
1_Q5_Q0.6560.82
97_E101_R0.6520.81
5_Q70_R0.6470.81
158_Q161_L0.6470.81
119_R162_V0.6330.79
109_R126_R0.6320.79
42_T75_G0.6250.78
89_D93_Y0.6250.78
70_R149_E0.6220.78
118_P170_A0.6200.78
29_G147_S0.6190.78
165_G178_R0.6150.77
167_L170_A0.6140.77
22_A58_G0.6140.77
18_R24_P0.6110.77
79_A132_L0.6100.77
57_W73_R0.6080.76
16_A55_S0.6080.76
4_A7_D0.6050.76
97_E100_K0.6050.76
34_P38_F0.6040.76
99_W106_S0.6010.76
1_Q4_A0.5990.75
49_L174_L0.5920.75
82_H139_R0.5920.75
177_E180_Y0.5890.74
44_I79_A0.5870.74
51_M126_R0.5860.74
141_V144_W0.5860.74
56_G126_R0.5850.74
53_Y126_R0.5840.74
3_R47_S0.5840.74
99_W103_L0.5820.73
102_A105_R0.5790.73
77_E80_L0.5770.73
113_D129_Q0.5770.73
18_R64_E0.5760.73
86_S103_L0.5760.73
3_R125_R0.5760.73
143_E146_V0.5750.72
26_V68_A0.5740.72
65_R68_A0.5730.72
7_D73_R0.5700.72
71_I132_L0.5660.71
90_P98_E0.5640.71
78_W107_P0.5630.71
31_F36_F0.5630.71
30_R141_V0.5630.71
36_F137_L0.5610.71
79_A128_I0.5600.70
56_G109_R0.5580.70
87_S110_V0.5560.70
84_V87_S0.5550.70
108_V137_L0.5530.70
53_Y56_G0.5530.70
134_G137_L0.5530.70
48_F57_W0.5520.69
42_T79_A0.5490.69
89_D96_R0.5490.69
161_L170_A0.5480.69
60_K66_V0.5480.69
90_P96_R0.5470.69
57_W155_V0.5470.69
66_V156_R0.5450.68
49_L118_P0.5440.68
24_P34_P0.5420.68
22_A35_P0.5410.68
17_Y20_A0.5400.68
55_S152_T0.5370.67
1_Q47_S0.5340.67
57_W120_G0.5340.67
1_Q125_R0.5280.66
110_V116_R0.5280.66
167_L171_R0.5250.66
58_G64_E0.5250.66
168_D171_R0.5230.65
29_G116_R0.5230.65
133_R137_L0.5220.65
64_E88_F0.5210.65
24_P35_P0.5210.65
2_I80_L0.5210.65
75_G139_R0.5200.65
38_F42_T0.5180.65
116_R120_G0.5180.65
37_S86_S0.5160.64
84_V107_P0.5140.64
28_H34_P0.5120.64
140_Y145_I0.5110.64
60_K117_D0.5100.63
49_L122_P0.5090.63
118_P171_R0.5080.63
91_G98_E0.5060.63
81_A138_R0.5030.62
48_F52_M0.5020.62
4_A11_I0.5010.62
101_R168_D0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m70R 1 0.0056 6 0.969 Contact Map
2wb0X 1 0.4667 4.1 0.972 Contact Map
2nvnA 2 0.3778 3.2 0.973 Contact Map
4cylA 1 0.3333 3.1 0.973 Contact Map
1q9uA 2 0.4167 2.8 0.974 Contact Map
3a9sA 5 0.3278 2.6 0.974 Contact Map
3shgB 1 0.2889 2.5 0.974 Contact Map
2it9A 2 0.3722 2.3 0.975 Contact Map
3uqsA 4 0.2278 2.3 0.975 Contact Map
2kz3A 1 0.1556 2.1 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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