GREMLIN Database
DUF4290 - Domain of unknown function (DUF4290)
PFAM: PF14123 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 173 (172)
Sequences: 4067 (2350)
Seq/√Len: 179.2
META: 0.916

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_K74_K4.9681.00
36_N40_K3.5901.00
32_R76_D3.4941.00
118_K121_E3.4241.00
161_K169_K3.3631.00
32_R78_D3.3141.00
26_A42_I3.1691.00
25_H28_T2.7741.00
71_S74_K2.5581.00
39_A67_L2.4481.00
29_I38_C2.4061.00
2_E7_R2.2311.00
26_A38_C2.2021.00
73_F89_L2.1971.00
120_I167_K2.1511.00
122_M125_G2.0731.00
68_F79_S2.0581.00
27_K71_S2.0511.00
8_E24_D2.0081.00
107_H159_D2.0001.00
138_H141_K1.9911.00
72_D86_K1.9891.00
68_F83_I1.9691.00
105_Y162_E1.8741.00
125_G129_E1.8101.00
26_A39_A1.7371.00
34_E37_R1.7251.00
158_K161_K1.7201.00
116_I164_S1.7091.00
117_D121_E1.6111.00
34_E38_C1.6041.00
31_D34_E1.5911.00
125_G128_K1.5841.00
101_N110_K1.5731.00
79_S82_P1.5131.00
47_G53_L1.4931.00
130_A133_R1.4831.00
119_A135_I1.4721.00
23_V71_S1.4691.00
21_K24_D1.4131.00
85_T88_E1.3981.00
124_D128_K1.3851.00
79_S83_I1.3761.00
132_I168_L1.3351.00
33_E37_R1.3031.00
25_H29_I1.3001.00
91_E94_E1.2981.00
2_E21_K1.2901.00
43_I63_L1.2801.00
61_H65_D1.2781.00
155_V159_D1.2321.00
140_K153_D1.2191.00
43_I67_L1.2181.00
116_I160_L1.1921.00
103_I113_E1.1831.00
112_I135_I1.1761.00
111_N114_L1.1741.00
4_N7_R1.1741.00
29_I34_E1.1721.00
22_M38_C1.1661.00
45_V48_N1.1641.00
116_I135_I1.1611.00
45_V49_L1.1571.00
38_C41_A1.1491.00
138_H142_S1.1431.00
128_K132_I1.1281.00
112_I142_S1.1251.00
47_G59_F1.1111.00
68_F77_V1.0911.00
130_A134_L1.0901.00
83_I86_K1.0681.00
15_Y66_H1.0631.00
33_E36_N1.0621.00
154_E158_K1.0501.00
126_E129_E1.0491.00
23_V67_L1.0491.00
159_D162_E1.0481.00
110_K113_E1.0451.00
46_M63_L1.0210.99
110_K114_L1.0190.99
119_A131_L1.0160.99
36_N78_D1.0110.99
52_H56_V1.0100.99
108_Y159_D1.0100.99
129_E132_I1.0100.99
155_V158_K1.0030.99
7_R21_K1.0010.99
44_E60_K1.0010.99
144_L151_V0.9970.99
119_A132_I0.9910.99
67_L75_L0.9900.99
164_S168_L0.9760.99
104_K113_E0.9670.99
140_K151_V0.9620.99
114_L117_D0.9600.99
58_D61_H0.9570.99
25_H38_C0.9520.99
11_I20_Q0.9360.99
18_N21_K0.9340.99
122_M127_E0.9320.99
53_L59_F0.9290.99
52_H55_D0.9240.99
114_L118_K0.9240.99
119_A168_L0.9070.99
124_D129_E0.9020.99
69_I73_F0.9000.99
117_D120_I0.8960.99
118_K122_M0.8860.98
132_I160_L0.8800.98
143_Y156_I0.8790.98
24_D72_D0.8780.98
29_I32_R0.8680.98
99_P110_K0.8660.98
35_R39_A0.8640.98
121_E167_K0.8550.98
23_V42_I0.8490.98
113_E117_D0.8360.98
102_K110_K0.8340.98
151_V156_I0.8290.98
143_Y151_V0.8230.98
47_G54_R0.8150.97
136_A170_L0.8120.97
59_F63_L0.8090.97
52_H59_F0.8090.97
61_H81_Y0.8080.97
81_Y84_P0.8040.97
79_S84_P0.8020.97
88_E91_E0.7970.97
107_H139_M0.7970.97
136_A160_L0.7960.97
11_I72_D0.7920.97
111_N138_H0.7840.97
116_I168_L0.7830.97
160_L164_S0.7820.97
141_K144_L0.7820.97
8_E12_L0.7790.97
50_N53_L0.7780.97
137_N140_K0.7600.96
55_D60_K0.7550.96
50_N70_M0.7540.96
20_Q24_D0.7450.96
126_E130_A0.7420.95
129_E171_D0.7370.95
120_I128_K0.7290.95
32_R36_N0.7250.95
161_K164_S0.7160.95
65_D84_P0.7160.95
108_Y147_N0.7100.94
36_N68_F0.7090.94
100_Q103_I0.7020.94
113_E163_L0.6950.94
65_D82_P0.6820.93
47_G60_K0.6800.93
86_K90_E0.6800.93
30_E34_E0.6790.93
11_I70_M0.6780.93
144_L150_S0.6780.93
102_K113_E0.6770.93
14_E62_K0.6760.93
53_L61_H0.6670.92
47_G55_D0.6660.92
101_N115_M0.6610.92
65_D81_Y0.6610.92
24_D70_M0.6600.92
143_Y146_W0.6600.92
93_P96_L0.6570.92
10_L13_P0.6550.91
152_D155_V0.6550.91
30_E33_E0.6540.91
44_E47_G0.6510.91
30_E123_E0.6460.91
35_R78_D0.6430.91
104_K165_D0.6390.90
52_H61_H0.6370.90
142_S146_W0.6370.90
143_Y148_K0.6370.90
144_L149_D0.6360.90
78_D81_Y0.6360.90
38_C42_I0.6340.90
87_E91_E0.6300.90
129_E133_R0.6290.90
69_I89_L0.6230.89
124_D167_K0.6100.88
122_M131_L0.6100.88
12_L23_V0.6100.88
56_V59_F0.6090.88
143_Y155_V0.6080.88
1_M143_Y0.6070.88
85_T89_L0.6050.88
74_K86_K0.6030.88
55_D58_D0.6020.88
53_L62_K0.6010.88
120_I168_L0.5970.87
120_I165_D0.5960.87
30_E121_E0.5910.87
112_I115_M0.5910.87
55_D59_F0.5890.87
73_F85_T0.5870.86
73_F93_P0.5860.86
8_E11_I0.5850.86
137_N141_K0.5830.86
36_N79_S0.5820.86
47_G63_L0.5810.86
132_I170_L0.5800.86
22_M26_A0.5790.86
19_I45_V0.5780.86
138_H159_D0.5770.85
53_L56_V0.5750.85
127_E141_K0.5730.85
112_I139_M0.5720.85
158_K162_E0.5720.85
54_R59_F0.5720.85
161_K165_D0.5710.85
68_F85_T0.5680.85
150_S155_V0.5660.84
37_R41_A0.5610.84
101_N114_L0.5610.84
47_G56_V0.5560.83
38_C45_V0.5530.83
127_E130_A0.5520.83
157_F168_L0.5460.82
147_N164_S0.5440.82
9_K72_D0.5440.82
120_I164_S0.5430.82
157_F161_K0.5430.82
22_M45_V0.5420.82
24_D27_K0.5400.81
68_F71_S0.5390.81
68_F159_D0.5360.81
20_Q70_M0.5350.81
117_D165_D0.5340.81
107_H152_D0.5300.80
101_N106_R0.5290.80
161_K166_G0.5270.80
148_K153_D0.5260.80
52_H58_D0.5240.80
9_K20_Q0.5240.80
141_K145_N0.5240.80
28_T38_C0.5230.79
133_R171_D0.5220.79
152_D157_F0.5210.79
8_E70_M0.5200.79
115_M139_M0.5200.79
105_Y163_L0.5190.79
106_R138_H0.5180.79
157_F172_E0.5180.79
141_K159_D0.5150.78
23_V26_A0.5130.78
46_M70_M0.5100.78
47_G61_H0.5100.78
82_P85_T0.5100.78
154_E172_E0.5090.78
2_E6_Q0.5060.77
11_I18_N0.5050.77
157_F169_K0.5050.77
47_G50_N0.5050.77
94_E97_P0.5010.76
39_A77_V0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kxgA 5 0.2428 11.1 0.96 Contact Map
3k49A 1 0.3757 6.3 0.965 Contact Map
2ve7A 1 0.8092 5.8 0.965 Contact Map
3bwtA 1 0.3699 5 0.966 Contact Map
2hinA 2 0.3237 4.7 0.967 Contact Map
1b4aA 5 0.2832 4.6 0.967 Contact Map
1rq6A 1 0.2139 3.9 0.968 Contact Map
3j20S 1 0.2428 3.3 0.969 Contact Map
1stzA 3 0.3006 3.3 0.969 Contact Map
2tnfA 3 0.2601 3.2 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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