GREMLIN Database
DUF4288 - Domain of unknown function (DUF4288)
PFAM: PF14119 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (84)
Sequences: 3829 (3092)
Seq/√Len: 337.3
META: 0.956

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_L26_L3.0831.00
40_K79_D2.9391.00
9_R65_I2.8471.00
10_I62_W2.6011.00
32_D36_E2.4611.00
4_A41_A2.3981.00
4_A70_L2.3841.00
5_K24_E2.3591.00
54_N58_Q1.9511.00
38_F42_E1.8271.00
38_F70_L1.8251.00
40_K43_A1.7321.00
45_G64_F1.7101.00
25_Q48_E1.6981.00
6_L45_G1.6921.00
51_S59_L1.6701.00
6_L27_R1.6281.00
11_I63_K1.6101.00
53_L59_L1.5701.00
54_N60_V1.4891.00
46_K49_E1.4731.00
9_R63_K1.4231.00
11_I61_R1.4071.00
22_F68_R1.3881.00
52_Y60_V1.3841.00
42_E64_F1.3761.00
10_I21_Q1.2851.00
33_S36_E1.2721.00
74_D81_A1.2581.00
67_V70_L1.2121.00
71_Y85_S1.2021.00
31_A37_A1.1891.00
14_D58_Q1.1271.00
53_L57_G1.1221.00
36_E40_K1.0981.00
27_R48_E1.0971.00
42_E46_K1.0961.00
5_K26_L1.0911.00
9_R20_P1.0611.00
27_R44_L1.0471.00
64_F67_V1.0031.00
3_L83_V0.9901.00
7_V68_R0.9861.00
5_K69_E0.9851.00
31_A36_E0.9821.00
50_D53_L0.9811.00
8_F25_Q0.9601.00
29_I41_A0.9561.00
12_V54_N0.9551.00
5_K68_R0.9481.00
2_Y34_E0.9471.00
39_E42_E0.9451.00
12_V60_V0.9331.00
36_E39_E0.9301.00
78_E81_A0.9181.00
7_V24_E0.9041.00
24_E68_R0.8851.00
51_S61_R0.8811.00
38_F67_V0.8631.00
16_G40_K0.8571.00
8_F48_E0.8561.00
69_E73_L0.8341.00
43_A47_E0.8211.00
13_G59_L0.8111.00
20_P65_I0.7881.00
50_D62_W0.7841.00
42_E66_G0.7801.00
12_V16_G0.7591.00
34_E70_L0.7541.00
12_V58_Q0.7460.99
21_Q52_Y0.7450.99
35_E39_E0.7250.99
32_D39_E0.7180.99
49_E53_L0.7180.99
47_E72_E0.7050.99
29_I40_K0.7020.99
13_G18_H0.7010.99
41_A45_G0.6990.99
6_L44_L0.6820.99
11_I18_H0.6800.99
13_G58_Q0.6620.99
8_F27_R0.6600.99
45_G49_E0.6600.99
35_E42_E0.6510.99
39_E43_A0.6460.99
34_E72_E0.6320.98
45_G48_E0.6320.98
21_Q62_W0.6300.98
28_L83_V0.6280.98
7_V10_I0.6270.98
75_D78_E0.6120.98
44_L79_D0.6040.98
72_E75_D0.5990.98
29_I44_L0.5930.97
26_L73_L0.5880.97
73_L77_L0.5710.97
13_G16_G0.5680.97
50_D56_D0.5650.97
11_I20_P0.5650.97
74_D78_E0.5640.97
35_E38_F0.5630.97
5_K22_F0.5610.96
45_G67_V0.5610.96
74_D77_L0.5600.96
8_F49_E0.5540.96
44_L48_E0.5540.96
28_L73_L0.5520.96
20_P23_E0.5490.96
77_L81_A0.5430.96
32_D43_A0.5430.96
69_E84_Y0.5340.95
52_Y55_P0.5310.95
8_F23_E0.5310.95
5_K84_Y0.5310.95
12_V52_Y0.5280.95
78_E84_Y0.5250.95
19_R22_F0.5220.95
49_E52_Y0.5210.95
27_R45_G0.5190.95
6_L67_V0.5150.94
1_W77_L0.5140.94
72_E78_E0.5080.94
5_K65_I0.5070.94
30_R34_E0.5070.94
3_L9_R0.5040.94
34_E69_E0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zrtD 1 0.3529 8.7 0.888 Contact Map
1pp9D 2 0.4 7.9 0.89 Contact Map
1tdjA 2 0.9647 3.9 0.905 Contact Map
3cx5D 2 0.4353 3.9 0.905 Contact Map
2yiuB 1 0.3059 3.9 0.905 Contact Map
2qsdA 2 0.6941 3.4 0.907 Contact Map
2z0lA 3 0.3882 3.3 0.909 Contact Map
3iauA 1 0.9765 2.7 0.913 Contact Map
2qjyB 1 0.3882 2.5 0.914 Contact Map
3vk8A 1 0.9529 2.5 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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