GREMLIN Database
DUF4287 - Domain of unknown function (DUF4287)
PFAM: PF14117 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (55)
Sequences: 11507 (5681)
Seq/√Len: 766.1
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_A42_E2.4111.00
32_K35_E2.2541.00
15_K19_E2.0881.00
4_A8_N1.8741.00
16_S19_E1.8401.00
41_K48_H1.7501.00
3_Q7_D1.7181.00
15_K23_L1.6661.00
24_A58_A1.5531.00
21_L58_A1.5311.00
46_L54_I1.4631.00
27_S39_W1.4411.00
21_L25_K1.3761.00
34_G38_A1.3731.00
5_Y50_H1.3461.00
37_V51_A1.3271.00
36_I55_V1.3141.00
23_L39_W1.2951.00
27_S43_E1.2951.00
24_A36_I1.2561.00
47_G50_H1.2131.00
7_D11_K1.2011.00
10_E16_S1.1901.00
20_W44_H1.1891.00
12_K50_H1.1471.00
5_Y9_I1.1271.00
24_A54_I1.1101.00
33_H52_N1.1071.00
39_W43_E1.1021.00
23_L44_H1.0731.00
18_E22_A1.0521.00
29_L35_E1.0191.00
30_T35_E1.0071.00
8_N11_K0.9871.00
7_D10_E0.9781.00
29_L36_I0.9631.00
53_A57_V0.9331.00
24_A40_L0.9191.00
33_H37_V0.9181.00
21_L57_V0.9051.00
22_A26_K0.8921.00
35_E38_A0.8861.00
29_L39_W0.8751.00
48_H52_N0.8511.00
33_H55_V0.8511.00
21_L24_A0.7991.00
18_E21_L0.7971.00
38_A41_K0.7871.00
37_V48_H0.7741.00
19_E23_L0.7691.00
23_L27_S0.7621.00
5_Y8_N0.7601.00
8_N12_K0.7521.00
4_A7_D0.7521.00
19_E22_A0.7461.00
49_G53_A0.7321.00
6_I17_L0.7271.00
49_G52_N0.7151.00
28_G36_I0.7141.00
17_L21_L0.7091.00
37_V52_N0.7011.00
33_H56_H0.6761.00
27_S36_I0.6541.00
20_W23_L0.6531.00
39_W44_H0.6391.00
24_A39_W0.6381.00
15_K20_W0.6331.00
9_I50_H0.6281.00
37_V41_K0.6251.00
10_E19_E0.5921.00
47_G53_A0.5911.00
33_H36_I0.5891.00
22_A25_K0.5841.00
34_G37_V0.5771.00
9_I53_A0.5771.00
46_L50_H0.5701.00
55_V58_A0.5401.00
38_A48_H0.5331.00
17_L57_V0.5281.00
8_N50_H0.5071.00
52_N55_V0.5061.00
12_K47_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xb2B 1 0.9667 46.1 0.8 Contact Map
3avxA 1 0.95 33.4 0.815 Contact Map
3gbgA 1 0.9333 31.8 0.818 Contact Map
2cp9A 1 0.8833 31.1 0.818 Contact Map
1zq1C 1 0.9833 27.2 0.823 Contact Map
4pc3C 1 0.95 27 0.824 Contact Map
2d6fC 1 0.9833 26.5 0.824 Contact Map
1aipC 2 0.95 26.4 0.825 Contact Map
1dd4C 7 0.6667 19.2 0.836 Contact Map
3ip4B 1 0.9833 18.6 0.836 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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