GREMLIN Database
DUF4284 - Immunity protein 22
PFAM: PF14112 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 123 (121)
Sequences: 1024 (828)
Seq/√Len: 75.3
META: 0.72

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_Y36_D6.8371.00
2_S119_S3.2341.00
48_E67_S2.9501.00
31_S34_A2.9301.00
20_E44_E2.7711.00
2_S116_F2.6721.00
116_F119_S2.4291.00
50_N66_F2.3341.00
93_I114_L2.2391.00
79_K120_F2.2021.00
72_F96_Y2.1391.00
10_S13_E2.0811.00
6_G90_N1.8291.00
14_L91_A1.8061.00
65_G69_S1.7981.00
58_P61_E1.7421.00
14_L18_F1.6421.00
48_E94_L1.6020.99
3_I76_L1.5990.99
5_I89_A1.5880.99
62_L65_G1.5810.99
76_L120_F1.5500.99
26_G29_I1.5500.99
72_F76_L1.4970.99
63_L76_L1.4490.99
2_S98_F1.4440.99
75_E78_E1.4260.99
48_E68_Y1.4130.99
69_S72_F1.4090.99
82_K85_L1.3670.98
20_E42_Y1.3610.98
27_D30_P1.3520.98
18_F49_A1.3460.98
100_Y116_F1.3180.98
6_G14_L1.2880.98
18_F93_I1.2800.97
20_E41_W1.2730.97
2_S37_F1.2650.97
6_G114_L1.2520.97
60_E77_K1.2380.97
41_W45_D1.2170.97
67_S96_Y1.2020.96
36_D62_L1.1770.96
37_F100_Y1.1760.96
43_D46_F1.1330.95
34_A44_E1.1120.94
5_I117_I1.1090.94
2_S100_Y1.0980.94
26_G30_P1.0960.94
79_K82_K1.0800.93
23_D40_D1.0750.93
37_F98_F1.0600.93
23_D28_S1.0500.92
104_P107_V1.0480.92
41_W44_E1.0450.92
80_A89_A1.0380.92
71_S120_F1.0010.91
51_F91_A0.9950.90
102_G105_K0.9950.90
10_S79_K0.9860.90
3_I94_L0.9670.89
47_I95_L0.9620.89
22_Y43_D0.9600.89
11_E25_D0.9280.87
2_S97_D0.9230.87
72_F116_F0.9220.87
31_S42_Y0.9200.86
23_D27_D0.9190.86
43_D90_N0.9130.86
100_Y104_P0.9120.86
34_A41_W0.9100.86
62_L92_V0.9030.85
75_E79_K0.9030.85
66_F94_L0.8970.85
85_L89_A0.8940.85
1_V96_Y0.8920.85
2_S96_Y0.8720.83
10_S51_F0.8710.83
6_G10_S0.8630.83
42_Y101_D0.8580.82
73_I77_K0.8540.82
51_F90_N0.8500.82
1_V94_L0.8430.81
77_K80_A0.8270.80
6_G33_F0.8260.80
34_A42_Y0.8230.80
79_K83_K0.8190.79
55_E78_E0.8120.79
38_G41_W0.7990.78
4_W33_F0.7980.77
41_W46_F0.7880.77
32_Q38_G0.7870.76
11_E19_E0.7800.76
32_Q35_K0.7780.76
104_P109_N0.7710.75
21_D43_D0.7610.74
117_I120_F0.7590.74
9_P13_E0.7560.74
89_A115_K0.7550.73
62_L89_A0.7520.73
18_F91_A0.7460.73
102_G109_N0.7460.73
36_D112_N0.7440.72
14_L93_I0.7420.72
5_I83_K0.7350.71
65_G92_V0.7280.71
59_L84_G0.7220.70
68_Y76_L0.7190.70
108_K111_Y0.7160.69
14_L90_N0.7130.69
18_F47_I0.7100.69
18_F74_P0.7080.69
67_S72_F0.7070.68
65_G93_I0.7020.68
37_F96_Y0.7000.68
61_E84_G0.6900.67
22_Y67_S0.6880.66
78_E82_K0.6830.66
52_L61_E0.6770.65
109_N112_N0.6730.65
103_E107_V0.6700.64
46_F97_D0.6670.64
11_E15_E0.6670.64
3_I88_K0.6630.64
68_Y122_Y0.6580.63
32_Q36_D0.6520.62
44_E47_I0.6500.62
6_G91_A0.6490.62
38_G121_E0.6430.61
81_K86_E0.6420.61
14_L51_F0.6410.61
10_S14_L0.6380.61
4_W117_I0.6350.60
71_S74_P0.6330.60
18_F34_A0.6260.59
36_D49_A0.6260.59
48_E72_F0.6210.59
33_F51_F0.6210.59
9_P57_V0.6200.58
5_I34_A0.6180.58
14_L47_I0.6170.58
116_F121_E0.6140.58
19_E28_S0.6080.57
31_S72_F0.6050.57
1_V98_F0.6030.56
23_D74_P0.5890.55
23_D29_I0.5870.54
48_E92_V0.5870.54
93_I97_D0.5820.54
76_L92_V0.5720.52
3_I69_S0.5710.52
12_E86_E0.5640.51
6_G13_E0.5560.50
113_G116_F0.5540.50
29_I63_L0.5520.50
28_S38_G0.5500.50
22_Y95_L0.5480.49
36_D109_N0.5450.49
16_E82_K0.5440.49
108_K117_I0.5430.49
16_E21_D0.5420.49
40_D119_S0.5420.49
22_Y25_D0.5400.48
76_L80_A0.5390.48
1_V4_W0.5390.48
7_N85_L0.5390.48
48_E96_Y0.5340.48
70_E117_I0.5330.48
34_A37_F0.5320.47
58_P89_A0.5290.47
12_E15_E0.5210.46
77_K89_A0.5200.46
95_L98_F0.5190.46
73_I81_K0.5180.46
3_I65_G0.5170.46
55_E62_L0.5130.45
38_G110_E0.5110.45
101_D120_F0.5090.45
1_V71_S0.5080.44
31_S90_N0.5050.44
20_E51_F0.5020.44
8_F91_A0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1na6A 2 0.9431 8.2 0.915 Contact Map
1gccA 1 0.3008 6.2 0.92 Contact Map
1el6A 3 0.6992 3.4 0.929 Contact Map
4y66A 1 0.3496 3 0.931 Contact Map
1tr0A 7 0.3659 2.6 0.933 Contact Map
3fmbA 2 0.3577 2.4 0.935 Contact Map
3bguA 2 0.3577 2.3 0.935 Contact Map
1pyaB 3 0.8862 2.2 0.936 Contact Map
3sggA 1 0.3333 2.2 0.936 Contact Map
1d0nA 5 0.6098 2.2 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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