GREMLIN Database
DUF4282 - Domain of unknown function (DUF4282)
PFAM: PF14110 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (83)
Sequences: 5890 (4361)
Seq/√Len: 478.7
META: 0.921

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_G65_W4.6181.00
21_L62_L3.0571.00
28_G58_F2.5611.00
79_N83_R2.5131.00
81_N86_R2.3421.00
64_F68_Y2.3151.00
25_V58_F2.2131.00
78_I82_L2.1861.00
13_I69_C2.1441.00
24_I65_W2.0061.00
71_L75_L1.9151.00
75_L78_I1.8931.00
81_N84_A1.7081.00
3_S14_K1.6291.00
77_R80_E1.5371.00
28_G54_G1.5361.00
68_Y71_L1.5251.00
14_K18_W1.5251.00
24_I61_G1.5081.00
2_F18_W1.4721.00
74_V79_N1.4141.00
58_F62_L1.3951.00
6_R11_K1.3621.00
1_D5_D1.3561.00
82_L85_I1.2851.00
13_I73_I1.2781.00
45_L49_L1.2531.00
24_I58_F1.2371.00
5_D77_R1.2121.00
7_F73_I1.2041.00
47_G51_L1.1521.00
9_T67_I1.1451.00
20_G69_C1.1101.00
60_L64_F1.1081.00
47_G50_L1.0991.00
12_I16_L1.0931.00
39_S47_G1.0801.00
25_V62_L1.0471.00
18_W22_V1.0161.00
68_Y72_L1.0001.00
83_R86_R0.9961.00
78_I81_N0.9721.00
65_W69_C0.9221.00
82_L86_R0.9161.00
49_L53_L0.9081.00
30_G34_S0.9071.00
33_F36_F0.8981.00
31_G57_G0.8951.00
27_G61_G0.8791.00
77_R83_R0.8681.00
29_L33_F0.8501.00
46_G50_L0.8461.00
22_V26_L0.8391.00
79_N82_L0.8341.00
48_L51_L0.8221.00
39_S50_L0.8201.00
32_I54_G0.8131.00
9_T12_I0.8111.00
31_G34_S0.8081.00
3_S6_R0.8011.00
52_I55_P0.7921.00
44_P48_L0.7881.00
59_L62_L0.7871.00
44_P47_G0.7861.00
32_I35_G0.7831.00
36_F39_S0.7681.00
35_G47_G0.7541.00
65_W68_Y0.7431.00
47_G55_P0.7421.00
54_G58_F0.7391.00
55_P59_L0.7311.00
75_L79_N0.7161.00
72_L76_F0.7151.00
28_G55_P0.7091.00
43_S46_G0.7081.00
20_G24_I0.7001.00
53_L57_G0.6961.00
10_P80_E0.6931.00
11_K14_K0.6921.00
13_I76_F0.6851.00
43_S47_G0.6821.00
24_I62_L0.6751.00
34_S38_A0.6731.00
16_L69_C0.6731.00
4_F7_F0.6721.00
57_G61_G0.6601.00
10_P73_I0.6581.00
47_G54_G0.6531.00
17_Y62_L0.6521.00
32_I36_F0.6441.00
64_F72_L0.6431.00
16_L67_I0.6381.00
12_I67_I0.6301.00
61_G65_W0.6271.00
36_F47_G0.6210.99
55_P58_F0.6200.99
63_L67_I0.6200.99
26_L29_L0.6160.99
51_L55_P0.5900.99
3_S18_W0.5870.99
34_S37_G0.5820.99
17_Y59_L0.5820.99
38_A47_G0.5800.99
7_F74_V0.5730.99
52_I56_L0.5680.99
76_F82_L0.5670.99
35_G51_L0.5650.99
5_D14_K0.5630.99
30_G38_A0.5490.99
59_L63_L0.5480.99
32_I39_S0.5480.99
47_G52_I0.5450.99
49_L56_L0.5450.99
7_F77_R0.5450.99
28_G32_I0.5280.98
38_A50_L0.5250.98
10_P14_K0.5230.98
32_I51_L0.5220.98
9_T72_L0.5140.98
1_D62_L0.5100.98
27_G43_S0.5100.98
11_K15_V0.5020.98
49_L52_I0.5010.98
16_L63_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bs2C 2 0.977 1.8 0.894 Contact Map
2f93B 2 0.5172 1.3 0.901 Contact Map
4i5sA 2 0.2989 1.3 0.902 Contact Map
3wu2X 1 0.4368 1.3 0.902 Contact Map
3j5pB 3 1 1.1 0.905 Contact Map
2kluA 1 0.5517 1.1 0.905 Contact Map
5a63B 1 0.8966 1.1 0.906 Contact Map
4pbyC 1 0 1.1 0.906 Contact Map
3tx3A 2 0.9425 1.1 0.907 Contact Map
4ev6A 3 0.8276 1 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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