GREMLIN Database
GldH_lipo - GldH lipoprotein
PFAM: PF14109 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 128 (127)
Sequences: 7412 (5806)
Seq/√Len: 515.2
META: 0.926

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_G88_Y2.8531.00
74_D78_K2.6351.00
25_E104_T2.6221.00
23_E104_T2.5101.00
23_E106_T2.4641.00
57_T108_T2.3541.00
13_G117_P2.2321.00
41_N90_N2.1731.00
53_F112_A2.1591.00
19_T110_E2.1191.00
55_T108_T2.0381.00
42_T122_T2.0061.00
60_D101_K2.0031.00
15_N117_P1.9761.00
55_T110_E1.9411.00
21_S108_T1.9091.00
73_A79_W1.8361.00
21_S106_T1.7831.00
55_T65_T1.7381.00
38_N91_R1.7111.00
42_T120_G1.6761.00
24_F107_F1.6541.00
70_Y92_L1.6541.00
19_T108_T1.6471.00
57_T106_T1.5841.00
15_N18_D1.5801.00
51_Y69_E1.5741.00
46_P119_P1.5571.00
93_P96_E1.5471.00
7_K20_L1.5441.00
40_R123_D1.5431.00
4_E127_R1.4801.00
32_P98_R1.4791.00
91_R127_R1.4571.00
41_N79_W1.4491.00
36_Y93_P1.3981.00
47_Y115_E1.3981.00
49_N69_E1.3871.00
87_I122_T1.3771.00
109_I124_V1.3591.00
54_V109_I1.3421.00
115_E119_P1.3331.00
9_I20_L1.3161.00
10_P18_D1.2721.00
43_N88_Y1.2711.00
29_T102_K1.2711.00
107_F126_L1.2531.00
46_P115_E1.2371.00
8_S123_D1.2311.00
36_Y91_R1.2311.00
57_T63_T1.1891.00
6_Y38_N1.1881.00
3_Y22_F1.1781.00
40_R87_I1.1781.00
53_F67_T1.1501.00
40_R89_E1.1441.00
16_K116_D1.1391.00
32_P97_N1.1191.00
4_E38_N1.1121.00
59_P103_G1.0861.00
80_L90_N1.0611.00
55_T63_T1.0531.00
35_L126_L1.0391.00
48_S71_E1.0381.00
67_T112_A1.0381.00
54_V68_L1.0371.00
46_P120_G1.0361.00
53_F110_E1.0331.00
20_L124_V1.0221.00
2_V33_Y1.0161.00
10_P13_G1.0101.00
39_L50_L0.9991.00
90_N93_P0.9991.00
24_F128_I0.9921.00
109_I126_L0.9621.00
74_D80_L0.9551.00
7_K18_D0.9481.00
41_N88_Y0.9311.00
29_T32_P0.9241.00
51_Y112_A0.9011.00
7_K22_F0.8821.00
34_N97_N0.8811.00
56_T107_F0.8751.00
28_D31_S0.8731.00
34_N95_K0.8701.00
66_D95_K0.8551.00
58_F62_K0.8541.00
34_N93_P0.8541.00
34_N96_E0.8431.00
50_L121_I0.8291.00
52_L70_Y0.8241.00
37_L124_V0.8231.00
48_S75_P0.8221.00
41_N72_L0.8201.00
44_D120_G0.8191.00
37_L52_L0.8171.00
51_Y114_R0.8101.00
51_Y113_M0.8081.00
53_F65_T0.8081.00
41_N121_I0.7921.00
45_Y49_N0.7821.00
37_L54_V0.7771.00
53_F66_D0.7761.00
56_T95_K0.7741.00
38_N127_R0.7741.00
6_Y123_D0.7631.00
12_N122_T0.7621.00
111_Q118_L0.7571.00
9_I18_D0.7561.00
33_Y99_F0.7551.00
45_Y113_M0.7511.00
100_P105_Y0.7391.00
99_F107_F0.7381.00
26_I103_G0.7341.00
50_L118_L0.7261.00
36_Y127_R0.7241.00
37_L109_I0.7111.00
84_F88_Y0.7081.00
37_L94_Y0.7061.00
13_G119_P0.7011.00
71_E80_L0.7001.00
9_I124_V0.6991.00
111_Q114_R0.6991.00
26_I99_F0.6961.00
95_K98_R0.6941.00
58_F101_K0.6931.00
27_T102_K0.6871.00
59_P105_Y0.6871.00
35_L128_I0.6831.00
40_R122_T0.6811.00
43_N86_D0.6621.00
38_N89_E0.6581.00
64_I95_K0.6451.00
18_D21_S0.6421.00
71_E92_L0.6351.00
113_M118_L0.6291.00
48_S73_A0.6241.00
30_T33_Y0.6181.00
49_N114_R0.6121.00
76_D80_L0.6071.00
68_L95_K0.6041.00
49_N113_M0.5920.99
41_N73_A0.5890.99
61_G64_I0.5890.99
39_L70_Y0.5880.99
9_I13_G0.5830.99
39_L121_I0.5800.99
45_Y50_L0.5790.99
86_D89_E0.5790.99
98_R102_K0.5750.99
43_N83_G0.5750.99
9_I12_N0.5720.99
24_F56_T0.5690.99
84_F89_E0.5640.99
20_L24_F0.5630.99
37_L70_Y0.5610.99
95_K107_F0.5610.99
81_G90_N0.5600.99
69_E73_A0.5600.99
54_V107_F0.5590.99
80_L92_L0.5590.99
10_P15_N0.5580.99
62_K101_K0.5550.99
73_A80_L0.5520.99
87_I123_D0.5510.99
47_Y118_L0.5510.99
125_G128_I0.5490.99
4_E91_R0.5440.99
4_E7_K0.5440.99
71_E74_D0.5440.99
86_D122_T0.5410.99
16_K19_T0.5360.99
71_E75_P0.5360.99
54_V94_Y0.5360.99
30_T98_R0.5350.99
50_L70_Y0.5350.99
99_F103_G0.5300.99
48_S69_E0.5300.99
35_L94_Y0.5280.99
16_K110_E0.5230.99
35_L99_F0.5200.99
35_L95_K0.5200.99
39_L90_N0.5170.98
89_E123_D0.5150.98
15_N116_D0.5080.98
54_V72_L0.5070.98
42_T86_D0.5020.98
43_N85_G0.5020.98
77_G81_G0.5010.98
41_N81_G0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ebkA 1 0.7812 16.7 0.907 Contact Map
3nkgA 1 0.8594 13.9 0.91 Contact Map
2p9rA 1 0.7422 11.8 0.913 Contact Map
4ziqA 2 0.75 10.1 0.916 Contact Map
3payA 4 0.7578 7.5 0.92 Contact Map
1ukxA 1 0.8203 6.7 0.922 Contact Map
2b39A 1 0.9453 6.5 0.923 Contact Map
2yroA 1 0.5781 5.8 0.924 Contact Map
3prxB 1 0.8984 5.7 0.925 Contact Map
4bq2A 4 0.8828 5.5 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.