GREMLIN Database
DUF4281 - Domain of unknown function (DUF4281)
PFAM: PF14108 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (126)
Sequences: 5170 (3514)
Seq/√Len: 313.0
META: 0.909

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_A74_P4.3501.00
98_D127_Y4.0711.00
95_I116_T3.3281.00
68_A77_L3.0821.00
6_A82_I2.7861.00
60_G66_G2.6221.00
44_A122_V2.5131.00
62_G66_G2.5021.00
114_L118_M2.3061.00
90_F124_L2.2821.00
18_I110_I2.1971.00
98_D102_R2.1151.00
42_A82_I2.0891.00
80_G84_Y1.9891.00
68_A72_S1.9441.00
105_P108_L1.8441.00
98_D101_R1.8301.00
24_R28_R1.8081.00
87_F91_V1.8001.00
6_A42_A1.7731.00
106_H110_I1.6951.00
23_W26_T1.6871.00
16_L26_T1.6591.00
65_A74_P1.6371.00
93_A97_R1.6151.00
109_V112_C1.5901.00
17_L96_V1.5401.00
115_L126_L1.5371.00
99_A109_V1.4821.00
13_F35_I1.4701.00
106_H109_V1.3731.00
4_S8_L1.3711.00
31_A93_A1.3651.00
73_N76_G1.3631.00
72_S77_L1.3611.00
96_V100_Q1.3501.00
8_L12_P1.3421.00
100_Q106_H1.3321.00
90_F94_W1.3031.00
63_S66_G1.2981.00
25_W28_R1.2811.00
95_I109_V1.2761.00
7_N11_L1.2651.00
18_I114_L1.2641.00
22_R100_Q1.2301.00
112_C126_L1.2231.00
15_L19_F1.2231.00
20_L23_W1.2071.00
69_A72_S1.1321.00
71_F80_G1.1311.00
39_L82_I1.0471.00
96_V109_V1.0461.00
71_F77_L1.0351.00
5_L9_L1.0321.00
47_I119_F1.0131.00
46_L75_W1.0101.00
53_G56_G1.0031.00
111_P114_L0.9971.00
95_I112_C0.9951.00
36_P40_A0.9951.00
97_R101_R0.9711.00
57_A60_G0.9651.00
43_Y83_H0.9491.00
8_L11_L0.9471.00
14_W92_G0.9461.00
102_R127_Y0.9231.00
46_L79_A0.9151.00
25_W29_L0.9141.00
66_G69_A0.9141.00
84_Y87_F0.8941.00
22_R27_R0.8931.00
24_R27_R0.8751.00
10_A13_F0.8671.00
90_F93_A0.8631.00
64_L68_A0.8591.00
6_A78_L0.8551.00
48_V51_L0.8411.00
9_L38_L0.8361.00
58_F69_A0.8291.00
22_R106_H0.8291.00
41_L45_Y0.8281.00
27_R97_R0.8221.00
55_G59_G0.8171.00
59_G70_L0.8101.00
9_L13_F0.8091.00
16_L23_W0.8001.00
26_T29_L0.8001.00
6_A85_L0.7981.00
78_L82_I0.7921.00
47_I50_L0.7871.00
50_L53_G0.7801.00
3_F67_V0.7740.99
51_L54_F0.7730.99
16_L20_L0.7710.99
70_L80_G0.7690.99
30_V35_I0.7630.99
23_W27_R0.7630.99
40_A124_L0.7610.99
119_F122_V0.7610.99
40_A86_A0.7540.99
22_R25_W0.7440.99
21_P26_T0.7370.99
27_R31_A0.7350.99
13_F17_L0.7340.99
52_L57_A0.7290.99
96_V106_H0.7240.99
54_F57_A0.7200.99
83_H121_P0.7170.99
72_S76_G0.7140.99
93_A96_V0.7130.99
107_L111_P0.7110.99
48_V52_L0.7110.99
65_A68_A0.7090.99
37_L125_L0.7070.99
51_L55_G0.7020.99
83_H88_D0.7020.99
4_S7_N0.6920.99
95_I98_D0.6870.99
74_P77_L0.6840.99
32_S97_R0.6810.99
2_L46_L0.6810.99
27_R100_Q0.6810.99
109_V113_L0.6700.99
94_W124_L0.6650.98
112_C127_Y0.6590.98
10_A117_F0.6540.98
64_L78_L0.6530.98
59_G62_G0.6520.98
109_V127_Y0.6510.98
22_R26_T0.6470.98
39_L42_A0.6470.98
55_G58_F0.6440.98
35_I38_L0.6430.98
37_L41_L0.6400.98
60_G63_S0.6400.98
15_L20_L0.6400.98
31_A36_P0.6350.98
91_V124_L0.6330.98
7_N62_G0.6250.98
52_L55_G0.6220.98
99_A104_I0.6150.97
97_R100_Q0.6140.97
92_G113_L0.6130.97
53_G57_A0.6100.97
56_G59_G0.6060.97
87_F120_G0.6050.97
99_A127_Y0.6020.97
70_L76_G0.5930.97
40_A125_L0.5920.97
14_W113_L0.5890.97
64_L77_L0.5850.97
96_V113_L0.5800.96
47_I51_L0.5740.96
81_W88_D0.5740.96
60_G69_A0.5730.96
38_L42_A0.5710.96
49_L52_L0.5680.96
5_L8_L0.5650.96
7_N10_A0.5650.96
117_F120_G0.5640.96
84_Y92_G0.5620.96
52_L56_G0.5600.96
108_L111_P0.5590.96
43_Y87_F0.5590.96
67_V70_L0.5580.96
7_N84_Y0.5560.95
104_I108_L0.5520.95
8_L15_L0.5510.95
49_L53_G0.5470.95
16_L30_V0.5390.95
100_Q109_V0.5380.95
21_P106_H0.5380.95
12_P16_L0.5310.94
33_I97_R0.5280.94
31_A97_R0.5280.94
2_L78_L0.5270.94
10_A85_L0.5260.94
83_H87_F0.5240.94
43_Y80_G0.5210.94
9_L12_P0.5190.93
80_G88_D0.5180.93
26_T31_A0.5150.93
116_T123_G0.5140.93
93_A101_R0.5040.92
16_L29_L0.5040.92
31_A96_V0.5020.92
59_G63_S0.5020.92
96_V99_A0.5000.92
9_L35_I0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v42A 2 0.4724 2.5 0.938 Contact Map
4l6vF 1 0.4409 2.2 0.94 Contact Map
2mwrA 1 0.2126 1.2 0.949 Contact Map
3wu2J 1 0.2283 1 0.951 Contact Map
4xk8J 1 0.3071 0.9 0.953 Contact Map
4kt0J 1 0.315 0.8 0.954 Contact Map
1jb0J 1 0.3228 0.8 0.954 Contact Map
3mk7C 2 0.5433 0.6 0.957 Contact Map
5a63B 1 0.4803 0.6 0.958 Contact Map
1rh5B 1 0.3386 0.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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