GREMLIN Database
DUF4280 - Domain of unknown function (DUF4280)
PFAM: PF14107 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 109 (109)
Sequences: 4450 (3363)
Seq/√Len: 322.1
META: 0.843

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_M85_M2.9001.00
7_L104_I2.8321.00
77_S89_T2.4281.00
37_I76_G2.3011.00
41_K44_V2.1651.00
3_M32_K2.1191.00
8_Q105_T2.0831.00
70_P97_A2.0371.00
93_K103_S2.0151.00
13_T51_M1.9911.00
16_S48_P1.8921.00
6_M106_D1.8711.00
31_G84_G1.7941.00
13_T53_K1.7841.00
40_N70_P1.7351.00
60_V63_A1.7291.00
89_T92_S1.7241.00
37_I86_P1.7221.00
43_M47_P1.7101.00
74_V95_M1.6921.00
11_F53_K1.6791.00
24_N83_G1.6641.00
6_M17_S1.6531.00
3_M19_L1.5931.00
8_Q103_S1.5711.00
40_N69_T1.5451.00
69_T94_L1.5011.00
82_I87_A1.4911.00
28_Y33_P1.4721.00
5_A108_G1.3981.00
93_K101_V1.3901.00
59_T66_I1.3751.00
10_S103_S1.3551.00
57_N60_V1.3371.00
95_M101_V1.3231.00
36_T85_M1.3101.00
90_N107_P1.2981.00
43_M66_I1.2971.00
29_I34_A1.2911.00
19_L47_P1.2851.00
11_F54_S1.2791.00
68_V97_A1.2481.00
40_N72_P1.2341.00
16_S47_P1.2031.00
2_V29_I1.1821.00
28_Y81_L1.1731.00
3_M20_V1.1691.00
37_I72_P1.1561.00
55_P61_A1.1421.00
21_L24_N1.1131.00
34_A82_I1.0911.00
34_A87_A1.0791.00
35_A88_L1.0741.00
23_S26_R1.0571.00
69_T102_I1.0551.00
81_L86_P1.0551.00
75_P92_S1.0541.00
6_M15_P1.0531.00
61_A64_T1.0531.00
7_L47_P1.0501.00
76_G88_L1.0431.00
75_P91_T1.0321.00
26_R83_G1.0051.00
66_I98_W0.9891.00
10_S100_G0.9861.00
3_M33_P0.9661.00
51_M60_V0.9571.00
13_T50_G0.9521.00
54_S61_A0.9491.00
30_G109_Q0.9481.00
29_I32_K0.9321.00
88_L104_I0.9281.00
7_L35_A0.9221.00
38_M72_P0.9191.00
76_G92_S0.9181.00
14_A50_G0.9151.00
24_N33_P0.9021.00
56_A99_G0.8871.00
54_S99_G0.8861.00
74_V93_K0.8751.00
21_L35_A0.8531.00
19_L35_A0.8461.00
8_Q53_K0.8441.00
54_S57_N0.8201.00
36_T39_D0.8061.00
71_A97_A0.8021.00
59_T63_A0.8011.00
1_V104_I0.8001.00
31_G34_A0.7971.00
46_I69_T0.7891.00
76_G86_P0.7851.00
24_N27_V0.7570.99
2_V32_K0.7560.99
77_S92_S0.7520.99
7_L46_I0.7510.99
59_T62_A0.7480.99
11_F101_V0.7310.99
27_V82_I0.7080.99
46_I67_P0.7070.99
56_A61_A0.7000.99
2_V30_G0.6960.99
55_P62_A0.6950.99
18_L35_A0.6950.99
28_Y32_K0.6780.99
68_V98_W0.6730.99
67_P97_A0.6700.99
4_G32_K0.6690.99
18_L21_L0.6680.99
55_P64_T0.6650.99
54_S58_P0.6510.98
58_P61_A0.6500.98
2_V108_G0.6490.98
77_S87_A0.6410.98
75_P93_K0.6400.98
51_M57_N0.6400.98
23_S41_K0.6330.98
2_V5_A0.6310.98
28_Y31_G0.6300.98
60_V64_T0.6260.98
23_S44_V0.6240.98
21_L44_V0.6180.98
12_G49_F0.6120.98
104_I107_P0.6040.97
6_M105_T0.6040.97
43_M59_T0.6010.97
81_L84_G0.6010.97
14_A51_M0.6000.97
40_N71_A0.5980.97
1_V5_A0.5870.97
74_V86_P0.5860.97
7_L16_S0.5810.97
90_N106_D0.5790.97
57_N98_W0.5790.97
54_S98_W0.5770.97
43_M48_P0.5760.97
69_T97_A0.5730.96
21_L33_P0.5710.96
11_F55_P0.5680.96
51_M59_T0.5660.96
20_V23_S0.5660.96
91_T103_S0.5630.96
80_V87_A0.5610.96
81_L85_M0.5600.96
77_S80_V0.5520.96
57_N64_T0.5510.96
7_L49_F0.5460.95
88_L94_L0.5460.95
18_L22_P0.5460.95
41_K68_V0.5450.95
57_N61_A0.5450.95
43_M46_I0.5420.95
30_G34_A0.5380.95
55_P58_P0.5320.95
74_V78_P0.5310.95
36_T88_L0.5260.94
5_A106_D0.5230.94
3_M35_A0.5230.94
80_V90_N0.5150.94
8_Q15_P0.5150.94
49_F102_I0.5140.94
19_L23_S0.5110.93
21_L26_R0.5110.93
41_K47_P0.5010.93
12_G16_S0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jiwD 1 0.789 11.3 0.896 Contact Map
4jivD 1 0.789 9.1 0.9 Contact Map
4ku0D 1 0.7982 7 0.905 Contact Map
3maeA 3 0.2569 1.7 0.931 Contact Map
4rkuN 1 0.5596 1.7 0.931 Contact Map
2nmmA 3 0.7339 1.5 0.932 Contact Map
2g7bA 1 0.3945 1.4 0.934 Contact Map
4oh4F 1 0.0826 1.2 0.937 Contact Map
1kdgA 4 0.3394 1.1 0.938 Contact Map
2wscN 1 0.5596 1 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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