GREMLIN Database
DUF4279 - Domain of unknown function (DUF4279)
PFAM: PF14106 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (114)
Sequences: 5721 (5092)
Seq/√Len: 476.9
META: 0.916

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_W35_R2.8201.00
64_E106_R2.5871.00
105_R109_E2.4201.00
22_W39_S2.3511.00
11_T40_W2.2571.00
6_D23_R2.2191.00
11_T18_P2.2161.00
9_E12_R2.0881.00
66_K69_A2.0661.00
23_R26_D2.0291.00
28_R35_R2.0281.00
67_K109_E1.9101.00
67_K71_R1.7761.00
105_R108_A1.7571.00
44_S55_H1.7191.00
98_E115_D1.7161.00
27_P34_V1.7151.00
104_L108_A1.6261.00
7_P23_R1.6131.00
9_E13_L1.5691.00
98_E113_E1.5241.00
44_S48_E1.4911.00
19_T42_L1.4781.00
20_R41_S1.4661.00
57_D102_E1.4521.00
3_D24_K1.4051.00
10_I14_L1.4051.00
5_L38_G1.3991.00
45_G58_E1.3591.00
101_P113_E1.3391.00
60_L106_R1.3381.00
106_R110_L1.3281.00
72_E76_R1.3251.00
53_E100_S1.3251.00
13_L72_E1.3171.00
28_R33_R1.3151.00
28_R34_V1.2831.00
21_S38_G1.2801.00
61_D106_R1.2741.00
57_D103_T1.2601.00
46_L55_H1.1991.00
8_D12_R1.1781.00
105_R111_G1.1761.00
44_S47_E1.1741.00
50_E54_E1.1661.00
24_K38_G1.1641.00
101_P108_A1.1601.00
64_E67_K1.1591.00
42_L62_R1.1571.00
13_L69_A1.1501.00
100_S103_T1.1451.00
53_E57_D1.1441.00
8_D23_R1.1341.00
53_E103_T1.1281.00
7_P38_G1.1251.00
22_W37_T1.1241.00
47_E58_E1.1211.00
42_L63_L1.1051.00
13_L76_R1.0901.00
55_H58_E1.0801.00
26_D35_R1.0681.00
6_D9_E1.0201.00
2_G6_D1.0061.00
101_P111_G0.9871.00
57_D106_R0.9871.00
49_S55_H0.9761.00
44_S58_E0.9731.00
66_K70_L0.9711.00
57_D100_S0.9641.00
74_K111_G0.9641.00
71_R74_K0.9611.00
58_E62_R0.9501.00
16_L62_R0.9271.00
55_H59_L0.9241.00
89_S92_G0.9211.00
70_L110_L0.9211.00
103_T106_R0.9071.00
99_L104_L0.9071.00
101_P104_L0.9031.00
2_G38_G0.8961.00
107_L114_L0.8931.00
57_D61_D0.8891.00
6_D38_G0.8731.00
22_W26_D0.8701.00
23_R38_G0.8621.00
9_E76_R0.8611.00
68_E71_R0.8451.00
103_T107_L0.8401.00
14_L66_K0.8351.00
33_R36_K0.8351.00
45_G48_E0.8311.00
7_P11_T0.8171.00
7_P21_S0.8111.00
51_D54_E0.8051.00
74_K79_V0.7921.00
27_P33_R0.7861.00
79_V112_A0.7851.00
69_A72_E0.7851.00
4_D76_R0.7841.00
19_T62_R0.7641.00
2_G77_Y0.7601.00
19_T43_S0.7481.00
16_L42_L0.7481.00
29_R32_S0.7471.00
20_R39_S0.7451.00
13_L73_L0.7441.00
8_D17_E0.7361.00
64_E70_L0.7361.00
87_L93_G0.7281.00
19_T40_W0.7271.00
27_P30_G0.7241.00
74_K81_I0.7211.00
35_R39_S0.7121.00
81_I112_A0.7111.00
72_E75_E0.7031.00
8_D21_S0.7031.00
101_P105_R0.7011.00
106_R109_E0.7001.00
90_S93_G0.6961.00
107_L112_A0.6941.00
52_L85_V0.6841.00
71_R109_E0.6801.00
102_E106_R0.6791.00
93_G96_G0.6781.00
64_E109_E0.6781.00
71_R75_E0.6691.00
11_T21_S0.6671.00
99_L103_T0.6601.00
24_K36_K0.6561.00
22_W28_R0.6491.00
56_L103_T0.6481.00
104_L114_L0.6451.00
70_L81_I0.6200.99
94_F97_L0.6160.99
71_R111_G0.6160.99
12_R15_G0.6140.99
86_F89_S0.6110.99
81_I85_V0.6110.99
87_L92_G0.6080.99
20_R43_S0.6060.99
62_R65_P0.6050.99
11_T14_L0.5930.99
60_L103_T0.5920.99
18_P21_S0.5920.99
62_R66_K0.5910.99
45_G62_R0.5860.99
4_D24_K0.5820.99
52_L83_C0.5800.99
56_L83_C0.5780.99
74_K77_Y0.5740.99
68_E72_E0.5730.99
6_D12_R0.5650.99
16_L66_K0.5610.99
11_T15_G0.5600.99
14_L70_L0.5560.99
28_R31_G0.5520.99
102_E105_R0.5500.99
91_N95_P0.5490.99
82_F115_D0.5470.99
54_E57_D0.5410.99
89_S94_F0.5390.99
58_E61_D0.5350.98
15_G66_K0.5330.98
50_E55_H0.5320.98
10_I40_W0.5310.98
87_L91_N0.5270.98
99_L114_L0.5270.98
101_P114_L0.5230.98
50_E53_E0.5220.98
11_T17_E0.5070.98
28_R32_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1avoB 3 0.5776 17.1 0.874 Contact Map
4nqwA 1 0.319 14.1 0.878 Contact Map
4jdpA 2 0.6034 9 0.889 Contact Map
3cuqA 1 0.4052 7.2 0.893 Contact Map
1s7oA 3 0.6724 7.1 0.894 Contact Map
1svdM 3 0.7931 6.9 0.894 Contact Map
1rp3A 1 0.3448 6.1 0.897 Contact Map
4j2oA 5 0.4052 5.8 0.898 Contact Map
4g5hA 3 0.5431 5.8 0.898 Contact Map
3s6jA 2 0.5862 5.5 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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