GREMLIN Database
DUF4278 - Domain of unknown function (DUF4278)
PFAM: PF14105 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (56)
Sequences: 1801 (1348)
Seq/√Len: 180.1
META: 0.832

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_L32_Y3.9321.00
50_T55_A3.6541.00
49_L56_Y2.1901.00
17_V20_T1.6891.00
21_E33_R1.6441.00
2_T11_E1.6141.00
27_Y30_N1.6041.00
19_K37_A1.6011.00
36_R39_A1.5501.00
2_T9_S1.5451.00
6_R28_R1.5391.00
16_A19_K1.5381.00
1_M4_T1.4681.00
18_E21_E1.3681.00
25_L34_T1.3131.00
20_T23_E1.3051.00
19_K35_R1.2981.00
11_E14_K1.2901.00
3_L10_Y1.2811.00
26_T31_H1.2651.00
32_Y36_R1.2161.00
19_K23_E1.2071.00
5_Y8_V1.2011.00
2_T10_Y1.1561.00
1_M29_G1.1531.00
41_P44_Q1.1501.00
17_V21_E1.1051.00
31_H36_R1.0200.99
37_A41_P0.9820.99
42_E45_P0.9740.99
27_Y51_Y0.9470.99
24_I32_Y0.9410.99
8_V11_E0.9370.99
45_P54_V0.9260.99
28_R53_G0.9200.99
39_A42_E0.9040.99
43_L46_S0.9020.99
48_E55_A0.8840.98
4_T8_V0.8830.98
8_V30_N0.8660.98
36_R40_A0.8610.98
31_H35_R0.8550.98
9_S14_K0.8340.98
23_E34_T0.8320.98
32_Y37_A0.8210.98
19_K24_I0.8190.98
28_R52_R0.7880.97
19_K22_V0.7630.96
4_T21_E0.7550.96
6_R27_Y0.7550.96
12_Q47_V0.7460.96
2_T8_V0.7400.95
8_V54_V0.7320.95
40_A43_L0.7310.95
53_G56_Y0.7190.95
4_T9_S0.6910.94
31_H34_T0.6800.93
18_E39_A0.6760.93
38_K41_P0.6650.92
24_I47_V0.6630.92
33_R43_L0.6620.92
16_A20_T0.6620.92
4_T13_H0.6450.91
37_A54_V0.6430.91
15_E24_I0.6410.91
43_L54_V0.6390.91
2_T28_R0.6210.89
29_G38_K0.6200.89
29_G36_R0.6180.89
37_A44_Q0.6020.88
11_E35_R0.5890.87
1_M25_L0.5830.86
3_L9_S0.5720.85
21_E54_V0.5680.85
10_Y52_R0.5590.84
44_Q47_V0.5550.83
6_R52_R0.5460.82
3_L56_Y0.5450.82
3_L49_L0.5270.80
48_E56_Y0.5110.78
25_L28_R0.5020.77
9_S38_K0.5020.77
8_V17_V0.5010.77
33_R36_R0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ea5A 2 0.5714 13.6 0.815 Contact Map
2h7cA 4 0.625 10.6 0.823 Contact Map
4fnmA 2 0.8571 10.1 0.825 Contact Map
1p0iA 2 0.5357 9.2 0.828 Contact Map
1thgA 1 0.5 9.2 0.828 Contact Map
1qe3A 1 0.5 9.1 0.829 Contact Map
4m0eA 2 0.6071 8.4 0.831 Contact Map
1llfA 2 0.4821 8.1 0.832 Contact Map
2ogtA 1 0.4821 8 0.833 Contact Map
4qwwA 2 0.5893 7.6 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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