GREMLIN Database
DUF4277 - Domain of unknown function (DUF4277)
PFAM: PF14104 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 109 (103)
Sequences: 8956 (4873)
Seq/√Len: 480.2
META: 0.97

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_G23_E4.7901.00
22_A44_L3.5431.00
26_D38_S2.7901.00
36_K82_D2.7831.00
17_D44_L2.6431.00
39_P91_A2.3461.00
43_V91_A2.1881.00
28_H106_E2.0791.00
65_A83_L1.9281.00
79_E82_D1.8951.00
22_A41_Q1.8691.00
16_L44_L1.8421.00
61_V88_L1.8421.00
38_S41_Q1.8071.00
39_P94_A1.7901.00
13_A17_D1.7241.00
45_A83_L1.6911.00
26_D40_G1.6091.00
27_R106_E1.5811.00
42_V91_A1.4981.00
24_I27_R1.4031.00
42_V87_R1.3731.00
13_A48_L1.3471.00
95_L100_R1.3231.00
99_G102_S1.3121.00
9_L48_L1.2901.00
16_L21_L1.2901.00
46_L88_L1.2861.00
20_G24_I1.2701.00
16_L22_A1.2571.00
43_V95_L1.2121.00
41_Q74_L1.2081.00
45_A74_L1.1691.00
26_D41_Q1.1421.00
100_R104_F1.1391.00
22_A26_D1.1121.00
24_I28_H1.0971.00
31_P34_R1.0841.00
41_Q76_E1.0791.00
84_N90_R1.0741.00
25_I43_V1.0731.00
31_P35_R1.0671.00
101_T105_T1.0631.00
60_R63_E1.0631.00
66_A80_A1.0611.00
62_P80_A1.0581.00
35_R94_A1.0551.00
8_H53_F1.0341.00
42_V88_L1.0251.00
35_R39_P1.0251.00
98_A103_L1.0241.00
24_I106_E0.9911.00
44_L48_L0.9801.00
29_L39_P0.9751.00
14_G17_D0.9681.00
54_G61_V0.9661.00
22_A40_G0.9611.00
23_E27_R0.9551.00
49_N64_W0.9471.00
36_K87_R0.9441.00
85_D89_G0.9381.00
16_L47_V0.9371.00
41_Q75_G0.9271.00
21_L47_V0.9271.00
63_E66_A0.9221.00
102_S106_E0.9141.00
49_N57_P0.9041.00
70_L74_L0.8991.00
17_D22_A0.8981.00
46_L61_V0.8941.00
62_P81_E0.8851.00
102_S105_T0.8781.00
15_F18_R0.8621.00
39_P42_V0.8611.00
98_A106_E0.8561.00
35_R87_R0.8481.00
32_D35_R0.8471.00
71_E75_G0.8441.00
71_E77_G0.8311.00
59_Y85_D0.8101.00
45_A65_A0.8091.00
70_L75_G0.8061.00
28_H103_L0.7941.00
86_D90_R0.7901.00
39_P87_R0.7851.00
8_H12_V0.7811.00
62_P84_N0.7781.00
34_R90_R0.7771.00
25_I29_L0.7761.00
96_F100_R0.7591.00
90_R93_D0.7581.00
72_L75_G0.7551.00
61_V64_W0.7521.00
16_L19_L0.7321.00
37_L45_A0.7321.00
101_T104_F0.7291.00
31_P38_S0.7281.00
75_G78_I0.7261.00
69_D72_L0.7231.00
24_I107_I0.7091.00
58_L93_D0.7071.00
46_L49_N0.6901.00
10_P50_I0.6871.00
70_L80_A0.6871.00
29_L98_A0.6861.00
9_L13_A0.6821.00
13_A44_L0.6821.00
49_N53_F0.6811.00
45_A61_V0.6731.00
16_L48_L0.6671.00
21_L107_I0.6671.00
89_G93_D0.6651.00
14_G18_R0.6611.00
10_P14_G0.6581.00
11_L15_F0.6521.00
50_I55_R0.6431.00
54_G60_R0.6421.00
4_E69_D0.6401.00
12_V51_L0.6230.99
24_I103_L0.6210.99
54_G57_P0.6130.99
57_P60_R0.6080.99
100_R105_T0.6080.99
81_E84_N0.6070.99
37_L42_V0.6050.99
37_L82_D0.6020.99
49_N54_G0.5950.99
31_P94_A0.5890.99
29_L94_A0.5860.99
65_A88_L0.5830.99
85_D90_R0.5820.99
25_I103_L0.5690.99
6_L68_K0.5660.99
22_A38_S0.5630.99
96_F105_T0.5590.99
70_L77_G0.5560.99
46_L92_L0.5550.99
74_L83_L0.5520.99
93_D96_F0.5500.99
55_R61_V0.5490.99
71_E74_L0.5360.98
32_D39_P0.5320.98
46_L91_A0.5310.98
24_I30_P0.5300.98
64_W68_K0.5280.98
6_L10_P0.5260.98
5_R68_K0.5240.98
103_L107_I0.5200.98
30_P98_A0.5190.98
87_R91_A0.5110.98
57_P89_G0.5080.98
58_L89_G0.5040.98
35_R69_D0.5020.98
44_L74_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rf7A 2 0.9174 5.8 0.92 Contact Map
1z67A 1 0.8807 4.7 0.924 Contact Map
3zokA 4 0.9541 3.4 0.928 Contact Map
2c4wA 2 0.6789 3.1 0.93 Contact Map
3m1tA 1 0.9174 2.8 0.932 Contact Map
2pftA 1 0.8532 2.6 0.932 Contact Map
3j16B 1 0.8349 2.5 0.933 Contact Map
3c19A 3 0.4312 2.3 0.935 Contact Map
3f3fC 2 0.3578 2.3 0.935 Contact Map
3dmqA 1 0.9817 2.3 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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