GREMLIN Database
Caps_synth_CapC - Capsule biosynthesis CapC
PFAM: PF14102 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 119 (119)
Sequences: 2794 (2035)
Seq/√Len: 186.6
META: 0.898

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_V68_M4.8381.00
49_I75_L3.9161.00
46_T71_V3.1081.00
64_R108_N2.9861.00
65_F108_N2.8441.00
53_L57_L2.6521.00
42_V75_L2.5831.00
52_L56_F2.4391.00
32_Q35_R2.4011.00
49_I71_V2.3721.00
3_L20_I2.2601.00
110_M115_V2.2551.00
47_Y51_R2.1211.00
7_L10_Y2.0421.00
9_F13_T1.8411.00
50_V71_V1.8061.00
30_L36_I1.7251.00
48_L52_L1.7041.00
59_L67_L1.6981.00
29_Y36_I1.6481.00
51_R55_R1.6421.00
113_Q118_T1.6321.00
45_L75_L1.6161.00
40_L119_L1.5511.00
76_G80_R1.5261.00
47_Y111_D1.5241.00
44_L48_L1.4721.00
44_L115_V1.4341.00
35_R38_V1.4311.00
7_L66_V1.4031.00
40_L44_L1.3911.00
8_L12_R1.3871.00
46_T75_L1.3761.00
24_G64_R1.3511.00
77_L81_L1.3471.00
36_I43_A1.3311.00
114_G117_R1.2971.00
68_M111_D1.2371.00
77_L80_R1.2351.00
54_S57_L1.2261.00
86_L89_G1.1901.00
43_A106_I1.1871.00
64_R111_D1.1301.00
65_F69_I1.1281.00
36_I39_T1.1201.00
53_L67_L1.1171.00
10_Y14_G1.1081.00
101_I105_L1.1041.00
88_P92_V1.0811.00
21_V101_I1.0761.00
72_G76_G1.0701.00
47_Y110_M1.0201.00
69_I100_Y1.0151.00
14_G19_G1.0101.00
86_L90_L1.0010.99
108_N111_D1.0000.99
89_G92_V0.9740.99
29_Y39_T0.9690.99
58_I65_F0.9680.99
17_A20_I0.9440.99
47_Y115_V0.9360.99
29_Y35_R0.9360.99
30_L33_P0.9110.99
58_I63_R0.9060.99
22_V39_T0.8970.99
34_L37_L0.8920.99
79_L92_V0.8840.99
3_L12_R0.8800.99
68_M108_N0.8750.99
89_G93_T0.8750.99
7_L17_A0.8710.99
3_L66_V0.8590.98
82_L88_P0.8540.98
18_G109_W0.8480.98
24_G114_G0.8460.98
85_P89_G0.8450.98
16_S109_W0.8300.98
13_T17_A0.8300.98
34_L38_V0.8240.98
106_I113_Q0.8210.98
13_T16_S0.8210.98
2_G23_P0.8150.98
10_Y16_S0.8080.98
10_Y21_V0.7980.97
4_V87_F0.7980.97
73_F100_Y0.7930.97
10_Y65_F0.7930.97
72_G103_P0.7860.97
80_R96_R0.7770.97
26_L36_I0.7740.97
45_L93_T0.7690.97
42_V72_G0.7680.97
38_V91_L0.7650.97
53_L56_F0.7550.96
6_S10_Y0.7460.96
73_F80_R0.7370.96
39_T43_A0.7340.96
64_R112_R0.7310.96
20_I100_Y0.7190.95
78_L86_L0.7140.95
50_V67_L0.7090.95
97_V100_Y0.7020.95
58_I76_G0.7010.95
108_N117_R0.6940.94
62_R102_I0.6920.94
53_L59_L0.6860.94
2_G22_V0.6840.94
68_M72_G0.6830.94
39_T106_I0.6790.94
55_R85_P0.6770.93
16_S24_G0.6710.93
104_G116_L0.6680.93
38_V97_V0.6660.93
62_R100_Y0.6620.93
103_P113_Q0.6510.92
39_T98_I0.6500.92
66_V111_D0.6450.92
51_R111_D0.6440.92
24_G27_A0.6430.92
34_L57_L0.6420.92
5_V12_R0.6380.91
90_L95_L0.6290.91
87_F90_L0.6270.91
20_I77_L0.6260.90
63_R103_P0.6250.90
7_L14_G0.6230.90
83_L97_V0.6210.90
87_F91_L0.6160.90
10_Y109_W0.6160.90
34_L41_L0.6130.90
90_L94_D0.6110.89
34_L82_L0.6110.89
35_R96_R0.6100.89
74_L90_L0.6090.89
69_I108_N0.6080.89
52_L55_R0.6080.89
81_L91_L0.6070.89
104_G109_W0.6040.89
34_L89_G0.5960.88
40_L77_L0.5950.88
43_A107_A0.5940.88
25_Y33_P0.5930.88
82_L85_P0.5910.88
9_F17_A0.5910.88
48_L78_L0.5880.88
81_L84_P0.5850.87
21_V100_Y0.5800.87
89_G94_D0.5730.86
13_T73_F0.5610.85
23_P99_G0.5600.85
74_L77_L0.5590.85
60_Y65_F0.5580.85
41_L91_L0.5580.85
84_P90_L0.5580.85
41_L45_L0.5570.85
4_V116_L0.5540.84
3_L109_W0.5450.83
69_I72_G0.5350.82
29_Y32_Q0.5330.82
25_Y69_I0.5310.82
97_V108_N0.5300.82
68_M101_I0.5290.82
34_L78_L0.5270.81
39_T103_P0.5270.81
6_S106_I0.5230.81
15_L20_I0.5200.80
43_A47_Y0.5200.80
60_Y66_V0.5180.80
10_Y18_G0.5130.80
69_I104_G0.5130.80
7_L69_I0.5110.79
65_F72_G0.5100.79
9_F112_R0.5100.79
95_L105_L0.5080.79
65_F109_W0.5050.78
10_Y13_T0.5040.78
23_P97_V0.5020.78
60_Y112_R0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hzqA 3 0.4958 3.1 0.924 Contact Map
4cadC 1 0.4622 2.2 0.93 Contact Map
2zy9A 2 0.6723 1.7 0.935 Contact Map
1pw4A 1 0.9832 1.6 0.935 Contact Map
4ogqG 1 0.1597 1.6 0.935 Contact Map
3o7qA 1 1 1.3 0.939 Contact Map
4lz6A 1 1 1.3 0.939 Contact Map
4j05A 3 0.9916 1.2 0.94 Contact Map
3wdoA 1 0.9916 1.1 0.941 Contact Map
1c17M 1 0.4454 1.1 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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