GREMLIN Database
PmoA - Methane oxygenase PmoA
PFAM: PF14100 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 271 (259)
Sequences: 9762 (7328)
Seq/√Len: 455.3
META: 0.912

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_R104_D4.2781.00
243_K246_E3.0031.00
132_D253_R2.9811.00
86_K102_E2.8721.00
174_E188_R2.7751.00
134_E249_T2.6851.00
66_D69_N2.5941.00
3_D13_S2.5681.00
191_D203_G2.4631.00
84_H87_F2.4361.00
191_D257_H2.4281.00
100_T119_T2.3571.00
60_G151_Y2.3251.00
45_E48_D2.2901.00
173_S187_A2.2441.00
265_E268_A2.2101.00
136_T247_S2.1851.00
172_N176_K2.1301.00
186_R218_Y2.0821.00
136_T249_T2.0671.00
102_E115_T2.0651.00
120_I133_F2.0561.00
203_G257_H2.0121.00
14_Y84_H2.0071.00
104_D112_V1.9931.00
115_T140_L1.9761.00
83_V106_V1.9491.00
88_L102_E1.8351.00
88_L100_T1.8121.00
33_L55_L1.7961.00
262_D265_E1.7861.00
169_T177_T1.7661.00
107_D111_K1.7581.00
34_R40_V1.7441.00
142_D244_P1.7311.00
138_T247_S1.6991.00
145_T241_T1.6971.00
143_P243_K1.6921.00
205_A266_I1.6701.00
104_D115_T1.6671.00
117_T136_T1.6501.00
89_E100_T1.6501.00
119_T134_E1.6281.00
112_V140_L1.6081.00
10_P13_S1.6071.00
154_F254_V1.6021.00
172_N182_V1.5731.00
176_K185_K1.5431.00
207_F255_V1.5401.00
121_T134_E1.5381.00
188_R267_A1.5361.00
6_I11_F1.5171.00
100_T117_T1.5141.00
55_L254_V1.5141.00
91_E98_V1.5011.00
61_D147_G1.5011.00
134_E251_R1.4941.00
208_D212_N1.4941.00
96_S121_T1.4921.00
67_F113_L1.4831.00
182_V221_V1.4801.00
123_Y130_L1.4761.00
143_P244_P1.4561.00
133_F154_F1.4561.00
12_T30_L1.4481.00
98_V121_T1.4261.00
173_S188_R1.4151.00
83_V104_D1.4121.00
106_V112_V1.4071.00
161_E196_V1.4071.00
255_V269_L1.4051.00
115_T138_T1.3931.00
114_L137_L1.3881.00
213_P240_L1.3771.00
208_D215_H1.3731.00
10_P34_R1.3691.00
130_L255_V1.3651.00
112_V115_T1.3651.00
195_P201_T1.3601.00
240_L248_L1.3471.00
102_E117_T1.3241.00
60_G149_T1.3171.00
114_L144_V1.3111.00
193_S261_A1.2991.00
143_P241_T1.2951.00
163_N166_G1.2951.00
98_V119_T1.2881.00
117_T138_T1.2751.00
217_T229_A1.2611.00
53_R70_E1.2531.00
233_A236_G1.2471.00
30_L120_I1.2431.00
35_T39_T1.2311.00
5_T10_P1.2241.00
55_L156_I1.2071.00
15_V29_Y1.2061.00
170_I182_V1.2021.00
5_T8_G1.2001.00
191_D205_A1.1991.00
35_T258_D1.1921.00
60_G66_D1.1811.00
172_N185_K1.1791.00
89_E98_V1.1691.00
167_G195_P1.1651.00
209_H251_R1.1641.00
88_L117_T1.1541.00
170_I221_V1.1511.00
146_F242_L1.1471.00
62_V105_W1.1351.00
4_V12_T1.1301.00
82_I103_N1.1251.00
158_V192_Y1.1211.00
61_D64_G1.1201.00
207_F270_W1.1171.00
11_F129_R1.1161.00
57_F153_G1.1151.00
177_T181_A1.1121.00
4_V122_F1.1121.00
12_T122_F1.1101.00
116_E135_I1.1091.00
263_A267_A1.1081.00
65_V108_P1.1051.00
39_T200_E1.1031.00
171_L177_T1.0851.00
128_A255_V1.0851.00
130_L253_R1.0821.00
176_K181_A1.0811.00
65_V107_D1.0811.00
169_T178_G1.0631.00
42_T54_G1.0601.00
169_T193_S1.0571.00
161_E195_P1.0481.00
35_T41_V1.0481.00
35_T202_V1.0411.00
205_A257_H1.0401.00
99_L120_I1.0401.00
84_H103_N1.0391.00
14_Y101_A1.0371.00
3_D10_P1.0321.00
260_D263_A1.0291.00
156_I204_I1.0251.00
93_G97_G1.0221.00
44_G53_R1.0171.00
103_N116_E1.0151.00
30_L33_L1.0131.00
214_R240_L1.0101.00
61_D149_T1.0081.00
232_T235_A1.0061.00
111_K141_T1.0041.00
37_S258_D1.0031.00
84_H101_A0.9981.00
188_R215_H0.9921.00
95_D123_Y0.9901.00
255_V266_I0.9871.00
25_L29_Y0.9841.00
87_F101_A0.9821.00
96_S123_Y0.9801.00
17_G24_E0.9781.00
33_L256_V0.9681.00
31_H54_G0.9641.00
213_P248_L0.9561.00
158_V204_I0.9521.00
128_A269_L0.9511.00
85_R102_E0.9501.00
172_N187_A0.9491.00
267_A270_W0.9491.00
171_L263_A0.9351.00
232_T236_G0.9281.00
200_E258_D0.9241.00
57_F135_I0.9191.00
145_T239_P0.9091.00
69_N149_T0.9071.00
93_G96_S0.9061.00
43_R160_R0.9041.00
31_H44_G0.9021.00
27_K70_E0.8991.00
174_E187_A0.8951.00
242_L248_L0.8901.00
171_L193_S0.8821.00
71_S79_Y0.8821.00
39_T198_D0.8811.00
41_V256_V0.8741.00
31_H42_T0.8731.00
179_E223_D0.8701.00
129_R256_V0.8691.00
6_I124_A0.8601.00
59_W153_G0.8591.00
257_H261_A0.8591.00
178_G181_A0.8521.00
29_Y44_G0.8501.00
60_G69_N0.8461.00
214_R217_T0.8461.00
82_I105_W0.8311.00
112_V141_T0.8301.00
65_V80_G0.8291.00
31_H40_V0.8241.00
260_D264_A0.8171.00
85_R106_V0.8161.00
214_R238_G0.8161.00
114_L242_L0.8141.00
95_D124_A0.8061.00
119_T136_T0.8021.00
4_V99_L0.8001.00
163_N167_G0.7991.00
33_L131_I0.7941.00
125_L130_L0.7921.00
215_H270_W0.7911.00
228_A231_P0.7891.00
101_A118_R0.7801.00
155_G228_A0.7801.00
176_K179_E0.7801.00
92_S97_G0.7721.00
30_L55_L0.7691.00
87_F90_V0.7671.00
125_L128_A0.7621.00
49_H52_H0.7611.00
114_L146_F0.7571.00
132_D251_R0.7541.00
182_V223_D0.7541.00
141_T244_P0.7481.00
162_L196_V0.7471.00
144_V242_L0.7421.00
39_T202_V0.7421.00
261_A265_E0.7411.00
9_K129_R0.7331.00
137_L146_F0.7271.00
103_N118_R0.7271.00
162_L194_G0.7251.00
122_F131_I0.7231.00
105_W137_L0.7191.00
30_L122_F0.7181.00
264_A268_A0.7161.00
196_V202_V0.7151.00
150_K183_W0.7131.00
123_Y132_D0.7101.00
36_P129_R0.7071.00
170_I192_Y0.7071.00
164_E167_G0.7061.00
46_P160_R0.7051.00
56_W155_G0.7041.00
172_N190_V0.7021.00
190_V227_F0.7001.00
171_L261_A0.6991.00
168_G173_S0.6961.00
224_Y228_A0.6901.00
206_I254_V0.6891.00
7_D124_A0.6851.00
242_L246_E0.6841.00
147_G239_P0.6831.00
81_R106_V0.6821.00
84_H88_L0.6811.00
118_R135_I0.6801.00
186_R237_D0.6791.00
203_G259_G0.6771.00
208_D217_T0.6771.00
167_G194_G0.6761.00
208_D216_P0.6751.00
197_G200_E0.6731.00
168_G192_Y0.6711.00
225_G228_A0.6691.00
211_S251_R0.6681.00
118_R133_F0.6641.00
70_E80_G0.6591.00
40_V44_G0.6541.00
85_R115_T0.6521.00
266_I270_W0.6511.00
149_T153_G0.6511.00
233_A237_D0.6501.00
63_N144_V0.6501.00
180_K223_D0.6501.00
103_N135_I0.6501.00
188_R270_W0.6491.00
63_N145_T0.6481.00
62_V67_F0.6481.00
124_A127_D0.6471.00
57_F133_F0.6431.00
106_V110_G0.6421.00
37_S202_V0.6411.00
63_N147_G0.6400.99
30_L131_I0.6380.99
209_H212_N0.6380.99
69_N79_Y0.6340.99
139_A242_L0.6300.99
76_K79_Y0.6290.99
158_V162_L0.6290.99
130_L269_L0.6270.99
57_F137_L0.6260.99
55_L133_F0.6260.99
6_I129_R0.6250.99
264_A267_A0.6230.99
218_Y237_D0.6210.99
107_D113_L0.6170.99
226_L230_N0.6150.99
261_A266_I0.6140.99
169_T260_D0.6120.99
123_Y131_I0.6120.99
219_W229_A0.6110.99
140_L244_P0.6100.99
262_D266_I0.6050.99
161_E198_D0.6020.99
226_L231_P0.6010.99
195_P199_G0.5980.99
37_S200_E0.5960.99
159_A196_V0.5930.99
43_R47_G0.5930.99
221_V227_F0.5930.99
91_E96_S0.5920.99
207_F253_R0.5910.99
67_F107_D0.5880.99
105_W114_L0.5860.99
183_W220_H0.5850.99
235_A240_L0.5830.99
116_E120_I0.5820.99
39_T196_V0.5820.99
232_T237_D0.5800.99
206_I229_A0.5770.99
260_D265_E0.5720.99
159_A162_L0.5700.99
243_K247_S0.5700.99
90_V99_L0.5690.99
170_I190_V0.5680.99
29_Y53_R0.5660.99
168_G172_N0.5650.99
207_F210_P0.5650.99
265_E269_L0.5640.99
61_D145_T0.5640.99
124_A129_R0.5630.99
55_L154_F0.5610.99
6_I97_G0.5600.99
26_R76_K0.5600.99
41_V202_V0.5590.99
135_I250_L0.5580.99
186_R208_D0.5580.99
35_T38_G0.5580.99
151_Y220_H0.5550.99
71_S77_D0.5500.98
92_S95_D0.5500.98
220_H226_L0.5440.98
226_L229_A0.5430.98
148_D238_G0.5430.98
105_W118_R0.5430.98
263_A266_I0.5400.98
181_A185_K0.5400.98
17_G23_D0.5400.98
12_T33_L0.5380.98
179_E183_W0.5370.98
16_Y87_F0.5360.98
234_P239_P0.5350.98
234_P237_D0.5350.98
262_D267_A0.5340.98
142_D243_K0.5300.98
27_K56_W0.5290.98
131_I254_V0.5290.98
214_R218_Y0.5290.98
40_V54_G0.5280.98
88_L101_A0.5280.98
43_R46_P0.5280.98
33_L42_T0.5270.98
67_F155_G0.5260.98
81_R110_G0.5260.98
222_R225_G0.5250.98
138_T244_P0.5230.98
154_F206_I0.5210.98
260_D267_A0.5200.98
176_K182_V0.5200.98
162_L202_V0.5200.98
5_T9_K0.5190.98
15_V24_E0.5170.98
187_A190_V0.5160.98
201_T260_D0.5160.98
232_T238_G0.5160.98
222_R228_A0.5140.98
164_E223_D0.5130.98
175_G178_G0.5120.98
62_V144_V0.5120.98
68_W71_S0.5110.98
58_A153_G0.5100.98
261_A269_L0.5100.98
58_A69_N0.5080.97
14_Y103_N0.5070.97
160_R166_G0.5060.97
170_I175_G0.5060.97
224_Y230_N0.5050.97
25_L53_R0.5050.97
58_A151_Y0.5020.97
65_V113_L0.5020.97
224_Y227_F0.5010.97
156_I206_I0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ep0A 1 0.3764 31.2 0.953 Contact Map
2kjpA 1 0.1476 18.1 0.958 Contact Map
2es7A 1 0.1033 15.4 0.96 Contact Map
4rz0A 2 0.3985 14.9 0.96 Contact Map
4i6xA 1 0.1328 11.7 0.962 Contact Map
3dalA 2 0.5978 10.8 0.962 Contact Map
1n3jA 2 0.428 10.8 0.962 Contact Map
2jt1A 1 0.1439 10.4 0.963 Contact Map
1v7wA 2 0.941 10 0.963 Contact Map
2qgvA 2 0.1181 9.4 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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