GREMLIN Database
SSPI - Small, acid-soluble spore protein I
PFAM: PF14098 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 65 (65)
Sequences: 638 (438)
Seq/√Len: 54.3
META: 0.583

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_I57_M3.4761.00
51_E54_K3.3331.00
50_D53_E2.6321.00
49_S57_M2.2241.00
15_S18_E2.2131.00
19_L61_L2.1751.00
2_N5_Q2.1061.00
1_L5_Q1.9471.00
44_V64_G1.9221.00
4_R43_E1.7190.99
27_I47_K1.7130.99
20_E54_K1.6600.99
29_S47_K1.4740.97
3_L11_V1.4300.96
53_E57_M1.4100.96
23_I58_L1.3950.96
59_E63_Q1.3350.95
53_E56_E1.3230.94
10_N31_E1.2530.93
11_V22_T1.2520.93
55_Q59_E1.2400.92
29_S34_T1.2240.92
48_N60_T1.1940.91
3_L36_P1.1570.89
19_L62_E1.1550.89
45_I61_L1.1200.88
16_E59_E1.1160.88
45_I49_S1.0940.87
48_N64_G1.0630.85
26_A31_E1.0390.84
16_E58_L1.0290.83
20_E24_E0.9950.81
6_A33_K0.9910.81
53_E60_T0.9850.80
56_E60_T0.9740.79
10_N22_T0.9710.79
60_T64_G0.9650.79
58_L61_L0.9550.78
11_V41_L0.9420.77
21_E25_D0.8770.72
51_E55_Q0.8720.71
2_N30_G0.8720.71
22_T26_A0.8650.71
14_N18_E0.8600.70
59_E62_E0.8490.69
55_Q63_Q0.8410.69
44_V48_N0.8250.67
14_N45_I0.8250.67
58_L62_E0.8070.65
42_F45_I0.8060.65
25_D32_E0.7980.65
7_I11_V0.7920.64
14_N22_T0.7830.63
3_L34_T0.7770.62
6_A11_V0.7710.62
16_E62_E0.7710.62
26_A33_K0.7410.59
3_L6_A0.7400.59
3_L41_L0.7360.58
7_I46_W0.7210.57
15_S50_D0.6960.54
27_I43_E0.6960.54
19_L57_M0.6810.53
32_E38_L0.6710.51
19_L58_L0.6710.51
1_L9_Q0.6690.51
26_A46_W0.6680.51
7_I44_V0.6670.51
49_S63_Q0.6650.51
52_E56_E0.6600.50
20_E44_V0.6600.50
48_N63_Q0.6490.49
30_G33_K0.6440.49
50_D56_E0.6370.48
52_E59_E0.6350.48
11_V19_L0.6350.48
18_E21_E0.6320.47
25_D28_Q0.6210.46
9_Q12_K0.6190.46
11_V23_I0.5990.44
50_D55_Q0.5990.44
7_I10_N0.5980.44
34_T47_K0.5800.42
2_N43_E0.5630.40
27_I58_L0.5600.40
7_I41_L0.5580.40
42_F61_L0.5500.39
2_N34_T0.5500.39
8_I44_V0.5500.39
53_E59_E0.5490.39
6_A38_L0.5470.38
24_E50_D0.5240.36
13_G58_L0.5230.36
21_E28_Q0.5210.36
33_K36_P0.5150.35
24_E28_Q0.5050.34
13_G28_Q0.5030.34
11_V14_N0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mydA 1 0.8308 26.3 0.874 Contact Map
2x24A 2 0 26 0.875 Contact Map
3a5iA 1 0.7538 22.1 0.878 Contact Map
4l2hA 1 0.9385 18.4 0.883 Contact Map
4wz8B 2 0.2462 13.9 0.889 Contact Map
3mixA 1 0.7385 13.9 0.889 Contact Map
4qjuA 2 0.9692 13.5 0.89 Contact Map
1a59A 2 0.8923 12.9 0.891 Contact Map
3my7A 2 0.6308 12.3 0.892 Contact Map
1cshA 2 0.8923 11.8 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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