GREMLIN Database
DUF4272 - Domain of unknown function (DUF4272)
PFAM: PF14094 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 208 (203)
Sequences: 1882 (1607)
Seq/√Len: 112.8
META: 0.834

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_H195_N3.7311.00
170_D174_N3.4321.00
37_V148_L3.2531.00
92_Q96_N2.9221.00
39_R75_A2.8331.00
67_L76_L2.7931.00
110_A197_L2.7361.00
2_K6_E2.6811.00
43_A76_L2.5851.00
158_A198_I2.5831.00
38_A143_I2.5271.00
188_Y192_Y2.4311.00
6_E17_N2.4081.00
90_S93_D2.3371.00
169_R172_R2.1611.00
165_H191_H1.9971.00
200_Y203_Q1.9961.00
165_H169_R1.9901.00
100_R192_Y1.9711.00
41_A104_L1.9631.00
81_R85_E1.9061.00
159_D163_R1.8961.00
43_A72_L1.8861.00
149_R153_E1.8831.00
33_S36_E1.8141.00
34_A38_A1.7931.00
32_R36_E1.7761.00
165_H168_V1.7571.00
157_A160_L1.7501.00
8_I12_L1.7441.00
86_N93_D1.7181.00
204_D207_D1.7091.00
125_D128_L1.6871.00
171_A179_P1.6651.00
138_S141_E1.6551.00
68_K73_W1.6361.00
35_E39_R1.6271.00
79_K96_N1.5871.00
41_A111_L1.5851.00
73_W76_L1.5541.00
44_L47_V1.5451.00
110_A154_I1.5361.00
66_W70_Y1.5351.00
6_E16_V1.5091.00
12_L119_F1.4981.00
161_I194_L1.4831.00
6_E18_P1.4831.00
51_A97_F1.4611.00
38_A146_A1.4581.00
105_W129_L1.4451.00
168_V184_P1.4401.00
92_Q95_I1.4381.00
31_L151_K1.4341.00
158_A195_N1.4191.00
67_L73_W1.3991.00
96_N185_G1.3751.00
113_L145_K1.3721.00
26_E152_E1.3711.00
105_W118_P1.3671.00
70_Y139_P1.3651.00
83_F97_F1.3591.00
40_R80_E1.3591.00
172_R184_P1.3541.00
103_A106_V1.3301.00
52_E101_Y1.3061.00
158_A194_L1.2970.99
185_G189_E1.2810.99
25_D28_E1.2680.99
41_A108_L1.2510.99
20_L162_Y1.2420.99
105_W114_V1.2350.99
64_E73_W1.2320.99
39_R143_I1.2140.99
123_I126_V1.2140.99
47_V97_F1.2090.99
107_L197_L1.2050.99
52_E126_V1.1770.99
83_F89_P1.1760.99
99_W185_G1.1720.99
49_A52_E1.1620.99
31_L154_I1.1560.99
65_E69_R1.1530.99
51_A83_F1.1320.99
141_E145_K1.1050.98
137_E145_K1.1040.98
77_T206_D1.1020.98
166_W170_D1.0980.98
50_R89_P1.0940.98
112_G147_K1.0930.98
70_Y138_S1.0860.98
3_A7_A1.0730.98
108_L113_L1.0730.98
160_L164_L1.0670.98
8_I11_A1.0670.98
170_D176_K1.0610.98
142_F146_A1.0490.98
38_A142_F1.0480.98
98_S123_I1.0450.98
48_A101_Y1.0400.97
43_A67_L1.0350.97
99_W189_E1.0330.97
168_V172_R1.0310.97
91_E94_R1.0270.97
48_A104_L1.0270.97
8_I157_A1.0270.97
5_S159_D1.0260.97
169_R173_L1.0110.97
179_P182_L0.9980.97
155_L159_D0.9980.97
14_I167_A0.9930.97
170_D173_L0.9890.97
161_I191_H0.9890.97
185_G188_Y0.9860.97
158_A161_I0.9830.96
119_F164_L0.9780.96
150_S153_E0.9710.96
157_A161_I0.9700.96
106_V117_L0.9660.96
105_W124_C0.9640.96
5_S8_I0.9640.96
51_A98_S0.9620.96
4_R156_D0.9560.96
21_P162_Y0.9530.96
2_K163_R0.9390.95
2_K5_S0.9390.95
47_V84_L0.9300.95
143_I146_A0.9270.95
111_L146_A0.9260.95
9_L14_I0.9170.95
165_H187_V0.9110.95
91_E95_I0.9070.94
103_A193_A0.9040.94
42_L72_L0.9030.94
67_L84_L0.9030.94
157_A194_L0.9000.94
46_A66_W0.8920.94
37_V197_L0.8900.94
83_F94_R0.8860.94
165_H188_Y0.8800.94
77_T107_L0.8800.94
67_L72_L0.8700.93
81_R84_L0.8680.93
50_R63_V0.8660.93
7_A11_A0.8660.93
15_P179_P0.8630.93
199_G202_D0.8630.93
35_E143_I0.8620.93
184_P188_Y0.8480.92
120_P161_I0.8440.92
48_A52_E0.8350.92
169_R188_Y0.8330.92
100_R189_E0.8250.91
128_L133_L0.8150.91
72_L75_A0.8120.90
10_K18_P0.8090.90
162_Y191_H0.8090.90
12_L164_L0.8000.90
168_V187_V0.7950.90
78_P207_D0.7870.89
106_V193_A0.7870.89
47_V100_R0.7800.89
4_R7_A0.7770.88
45_L104_L0.7740.88
104_L129_L0.7710.88
17_N20_L0.7670.88
59_P62_E0.7620.87
157_A190_R0.7580.87
163_R167_A0.7560.87
2_K20_L0.7540.87
105_W128_L0.7530.87
154_I194_L0.7480.87
103_A185_G0.7460.86
166_W173_L0.7390.86
8_I160_L0.7320.85
106_V194_L0.7300.85
120_P164_L0.7280.85
168_V171_A0.7270.85
161_I190_R0.7240.85
7_A10_K0.7210.84
48_A127_D0.7190.84
106_V191_H0.7160.84
20_L24_E0.7150.84
107_L110_A0.7080.83
167_A171_A0.7010.83
107_L193_A0.6990.83
42_L139_P0.6980.83
34_A148_L0.6970.82
48_A51_A0.6940.82
37_V111_L0.6860.81
76_L84_L0.6850.81
48_A191_H0.6850.81
50_R84_L0.6800.81
162_Y165_H0.6800.81
23_I29_V0.6760.80
195_N198_I0.6760.80
183_D187_V0.6750.80
130_V133_L0.6740.80
113_L146_A0.6680.80
15_P170_D0.6670.80
190_R194_L0.6650.79
44_L104_L0.6650.79
50_R60_R0.6510.78
72_L76_L0.6510.78
100_R103_A0.6510.78
22_L25_D0.6480.78
29_V151_K0.6440.77
10_K15_P0.6390.77
51_A94_R0.6390.77
17_N166_W0.6360.76
2_K17_N0.6310.76
58_E62_E0.6280.75
142_F145_K0.6250.75
10_K16_V0.6230.75
86_N89_P0.6210.75
151_K154_I0.6210.75
14_I23_I0.6130.74
160_L182_L0.6080.73
109_W149_R0.6070.73
15_P19_H0.6070.73
47_V83_F0.6060.73
23_I158_A0.6040.73
60_R63_V0.6010.72
26_E151_K0.6000.72
49_A97_F0.5990.72
76_L81_R0.5960.72
119_F187_V0.5930.71
38_A99_W0.5930.71
47_V86_N0.5920.71
9_L164_L0.5910.71
137_E141_E0.5880.71
6_E19_H0.5870.70
46_A104_L0.5850.70
95_I99_W0.5800.70
165_H173_L0.5780.69
123_I127_D0.5780.69
45_L130_V0.5780.69
96_N189_E0.5770.69
41_A129_L0.5770.69
60_R67_L0.5740.69
41_A107_L0.5720.68
22_L26_E0.5720.68
7_A12_L0.5700.68
95_I98_S0.5660.68
201_E204_D0.5660.68
60_R64_E0.5640.67
129_L133_L0.5630.67
51_A105_W0.5630.67
43_A47_V0.5620.67
6_E15_P0.5610.67
26_E31_L0.5590.67
37_V110_A0.5590.67
25_D29_V0.5580.67
159_D162_Y0.5570.66
126_V133_L0.5570.66
45_L133_L0.5550.66
178_A184_P0.5540.66
154_I163_R0.5520.66
39_R84_L0.5520.66
126_V131_R0.5510.66
27_E30_E0.5510.66
116_E176_K0.5510.66
2_K22_L0.5490.65
91_E116_E0.5480.65
73_W81_R0.5480.65
78_P204_D0.5470.65
162_Y166_W0.5470.65
44_L103_A0.5460.65
159_D187_V0.5450.65
140_E144_A0.5450.65
104_L124_C0.5420.64
118_P121_D0.5420.64
133_L142_F0.5390.64
3_A11_A0.5390.64
202_D208_V0.5370.64
106_V195_N0.5360.63
16_V19_H0.5360.63
64_E85_E0.5350.63
129_L132_L0.5350.63
158_A164_L0.5350.63
10_K65_E0.5320.63
118_P122_E0.5320.63
194_L205_W0.5310.63
73_W85_E0.5290.62
9_L171_A0.5280.62
159_D164_L0.5270.62
120_P156_D0.5270.62
199_G203_Q0.5240.62
101_Y134_P0.5220.61
139_P142_F0.5220.61
79_K93_D0.5210.61
118_P190_R0.5200.61
127_D183_D0.5180.61
23_I27_E0.5160.61
97_F100_R0.5150.60
3_A10_K0.5150.60
6_E163_R0.5110.60
21_P24_E0.5080.59
36_E39_R0.5080.59
69_R147_K0.5060.59
99_W169_R0.5050.59
35_E38_A0.5020.59
43_A135_L0.5020.59
58_E94_R0.5020.59
6_E10_K0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c9oA 3 0.3702 10.6 0.947 Contact Map
2zf8A 1 0.1683 4.9 0.954 Contact Map
3o0kA 1 0.4087 4.2 0.956 Contact Map
3wbwA 1 0.4663 4.1 0.956 Contact Map
3vxgA 1 0.4615 3.7 0.957 Contact Map
2i82A 1 0.2885 3.3 0.958 Contact Map
1ohuA 1 0.4519 2.9 0.959 Contact Map
4lgtA 1 0.2885 2.8 0.959 Contact Map
3axsA 2 0.375 2.7 0.96 Contact Map
1vioA 2 0.2404 2.6 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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