GREMLIN Database
DUF4271 - Domain of unknown function (DUF4271)
PFAM: PF14093 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 207 (202)
Sequences: 6003 (5128)
Seq/√Len: 360.8
META: 0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_S92_L4.8711.00
189_I193_C3.1181.00
61_S141_L3.0741.00
156_I159_L2.8041.00
88_F92_L2.6261.00
3_I7_L2.5621.00
172_R176_I2.3881.00
156_I160_I2.3851.00
38_Q41_R2.1881.00
62_L95_L2.1191.00
173_R177_I2.1081.00
8_L61_S2.1041.00
55_N131_K2.0381.00
110_G119_I2.0011.00
65_F159_L1.9781.00
16_K20_P1.9551.00
106_L119_I1.9261.00
166_F169_R1.9091.00
58_F130_N1.9091.00
90_I94_I1.8731.00
129_Y165_L1.8481.00
65_F141_L1.8411.00
59_I92_L1.8401.00
67_Y71_S1.8241.00
103_F127_F1.7691.00
67_Y84_G1.7251.00
166_F170_Y1.7221.00
85_F89_L1.6661.00
202_I205_K1.6051.00
69_L73_F1.6011.00
107_K120_S1.5981.00
59_I96_L1.5961.00
14_L18_L1.5851.00
63_S91_I1.5821.00
66_I91_I1.5771.00
107_K111_W1.5651.00
165_L169_R1.5591.00
103_F123_L1.5571.00
174_L177_I1.5501.00
200_L204_Y1.5391.00
8_L57_L1.5221.00
57_L134_G1.5061.00
68_L145_A1.5001.00
58_F62_L1.4881.00
5_L141_L1.4841.00
153_I159_L1.4641.00
102_K106_L1.4211.00
64_L88_F1.3961.00
201_L205_K1.3921.00
2_T146_Y1.3921.00
51_S131_K1.3631.00
67_Y91_I1.3581.00
66_I95_L1.3211.00
153_I156_I1.3191.00
68_L72_Y1.3101.00
189_I192_L1.3091.00
151_S154_I1.3011.00
126_K130_N1.2961.00
194_A198_L1.2801.00
62_L66_I1.2781.00
35_Y39_L1.2661.00
5_L142_L1.2601.00
155_L158_I1.2491.00
86_L89_L1.2481.00
162_L166_F1.2481.00
44_N47_F1.2451.00
170_Y173_R1.2421.00
154_I158_I1.2301.00
86_L90_I1.2231.00
58_F61_S1.2151.00
32_N35_Y1.2111.00
36_R41_R1.2081.00
139_P143_L1.2011.00
157_I161_L1.1841.00
12_L57_L1.1801.00
59_I63_S1.1791.00
149_L152_K1.1661.00
101_L105_L1.1581.00
107_K123_L1.1491.00
84_G88_F1.1471.00
147_S150_S1.1411.00
152_K156_I1.1401.00
169_R176_I1.1391.00
143_L147_S1.1371.00
16_K23_F1.1211.00
53_L57_L1.1071.00
115_I119_I1.0981.00
115_I118_L1.0901.00
50_F54_L1.0771.00
21_K25_D1.0771.00
154_I157_I1.0741.00
70_L75_L1.0741.00
151_S159_L1.0701.00
128_L132_L1.0681.00
153_I157_I1.0661.00
24_S28_R1.0601.00
88_F91_I1.0551.00
173_R176_I1.0551.00
21_K24_S1.0541.00
110_G196_E1.0531.00
59_I95_L1.0431.00
13_A17_L1.0431.00
106_L126_K1.0411.00
99_Y126_K1.0411.00
172_R177_I1.0331.00
39_L42_E1.0251.00
70_L74_G1.0231.00
38_Q42_E1.0211.00
178_F188_F1.0191.00
35_Y38_Q1.0171.00
163_L166_F1.0161.00
106_L122_Y1.0151.00
16_K19_F1.0031.00
57_L61_S1.0031.00
4_L88_F0.9971.00
103_F107_K0.9961.00
97_L101_L0.9921.00
29_S128_L0.9791.00
29_S34_K0.9771.00
68_L71_S0.9701.00
13_A16_K0.9691.00
34_K43_Q0.9681.00
15_L54_L0.9481.00
54_L57_L0.9401.00
160_I164_L0.9351.00
102_K196_E0.9311.00
70_L87_L0.9301.00
133_L165_L0.9261.00
101_L104_L0.9131.00
202_I206_L0.9101.00
89_L93_L0.9071.00
176_I180_L0.9051.00
177_I180_L0.8931.00
174_L178_F0.8931.00
8_L60_L0.8911.00
67_Y88_F0.8901.00
68_L141_L0.8871.00
127_F131_K0.8851.00
102_K126_K0.8771.00
46_L51_S0.8751.00
162_L165_L0.8651.00
36_R42_E0.8611.00
70_L91_I0.8601.00
74_G77_L0.8591.00
173_R179_K0.8571.00
178_F181_I0.8561.00
58_F134_G0.8511.00
175_F188_F0.8481.00
181_I185_L0.8421.00
8_L11_L0.8391.00
55_N127_F0.8361.00
108_L112_I0.8361.00
150_S153_I0.8331.00
160_I163_L0.8281.00
111_W116_K0.8251.00
106_L123_L0.8231.00
102_K130_N0.8221.00
181_I188_F0.8201.00
85_F88_F0.8131.00
38_Q43_Q0.8101.00
98_F126_K0.8091.00
122_Y126_K0.8021.00
34_K38_Q0.8011.00
44_N48_S0.8001.00
79_I83_S0.7981.00
195_L198_L0.7981.00
63_S88_F0.7921.00
127_F130_N0.7921.00
4_L8_L0.7911.00
3_I10_L0.7891.00
126_K129_Y0.7861.00
16_K24_S0.7791.00
32_N36_R0.7751.00
134_G141_L0.7741.00
192_L200_L0.7721.00
164_L168_L0.7701.00
58_F99_Y0.7681.00
126_K188_F0.7671.00
22_R25_D0.7641.00
198_L202_I0.7621.00
55_N59_I0.7601.00
76_L79_I0.7591.00
181_I184_S0.7571.00
170_Y188_F0.7491.00
136_L165_L0.7461.00
125_N129_Y0.7441.00
185_L189_I0.7401.00
126_K169_R0.7381.00
61_S65_F0.7361.00
99_Y200_L0.7331.00
69_L72_Y0.7331.00
22_R39_L0.7321.00
93_L97_L0.7321.00
128_L182_K0.7281.00
164_L167_L0.7271.00
183_F188_F0.7251.00
196_E200_L0.7251.00
86_L108_L0.7221.00
185_L190_L0.7210.99
163_L170_Y0.7150.99
190_L195_L0.7130.99
43_Q124_F0.7130.99
59_I99_Y0.7130.99
7_L11_L0.7120.99
33_T37_Q0.7110.99
104_L108_L0.7110.99
73_F76_L0.7110.99
11_L78_S0.7070.99
20_P24_S0.7060.99
37_Q40_F0.7050.99
25_D29_S0.7020.99
61_S134_G0.7010.99
65_F144_L0.6980.99
110_G113_F0.6980.99
60_L88_F0.6960.99
136_L139_P0.6960.99
113_F196_E0.6960.99
175_F178_F0.6950.99
22_R43_Q0.6940.99
46_L49_R0.6930.99
193_C197_I0.6920.99
65_F72_Y0.6810.99
12_L16_K0.6810.99
102_K127_F0.6790.99
30_F132_L0.6780.99
184_S188_F0.6770.99
28_R62_L0.6750.99
15_L57_L0.6730.99
6_L10_L0.6730.99
143_L149_L0.6730.99
141_L145_A0.6730.99
187_Y192_L0.6720.99
141_L144_L0.6710.99
163_L167_L0.6670.99
183_F198_L0.6510.99
128_L131_K0.6480.99
107_K116_K0.6460.99
27_F31_F0.6440.99
106_L110_G0.6400.99
54_L58_F0.6370.99
79_I93_L0.6310.99
110_G123_L0.6260.99
33_T176_I0.6260.99
45_L48_S0.6220.99
109_L112_I0.6220.99
83_S86_L0.6210.99
6_L9_L0.6140.98
78_S155_L0.6140.98
23_F27_F0.6070.98
135_L139_P0.6070.98
17_L20_P0.6060.98
173_R178_F0.6040.98
74_G152_K0.6030.98
163_L169_R0.6030.98
133_L136_L0.5930.98
122_Y173_R0.5920.98
122_Y166_F0.5920.98
9_L13_A0.5890.98
111_W114_N0.5820.98
89_L97_L0.5820.98
22_R26_L0.5780.98
201_L204_Y0.5770.98
71_S94_I0.5760.98
29_S39_L0.5700.97
27_F125_N0.5700.97
75_L83_S0.5570.97
150_S155_L0.5540.97
120_S124_F0.5530.97
9_L138_L0.5520.97
153_I158_I0.5500.97
188_F192_L0.5500.97
113_F122_Y0.5490.97
167_L183_F0.5470.97
125_N173_R0.5470.97
168_L172_R0.5470.97
28_R35_Y0.5460.97
61_S138_L0.5460.97
129_Y166_F0.5450.97
106_L195_L0.5440.97
40_F48_S0.5400.96
177_I181_I0.5380.96
12_L135_L0.5360.96
65_F166_F0.5350.96
92_L96_L0.5340.96
29_S33_T0.5320.96
15_L53_L0.5320.96
17_L21_K0.5260.96
139_P142_L0.5210.96
52_L56_L0.5200.96
37_Q43_Q0.5200.96
179_K182_K0.5170.95
5_L9_L0.5160.95
170_Y174_L0.5140.95
161_L165_L0.5120.95
171_I175_F0.5080.95
177_I183_F0.5080.95
190_L193_C0.5080.95
169_R173_R0.5050.95
59_I103_F0.5040.95
143_L146_Y0.5030.95
110_G122_Y0.5020.95
18_L90_I0.5010.95
27_F30_F0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mv6A 1 0.1401 2.3 0.931 Contact Map
2xq2A 2 0.4396 1.5 0.938 Contact Map
2kncA 1 0.1884 1.3 0.94 Contact Map
3dh4A 3 0.314 1.2 0.941 Contact Map
2m3eA 1 0.1691 0.9 0.945 Contact Map
1g92A 1 0.0531 0.9 0.946 Contact Map
3j01B 1 0.3961 0.8 0.947 Contact Map
2ks1B 1 0.1159 0.7 0.949 Contact Map
3wu2H 1 0.1594 0.7 0.949 Contact Map
2m20A 2 0.2319 0.7 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.