DUF4270 - PFAM28P - GREMLIN Contacts

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DUF4270 - Domain of unknown function (DUF4270)

PFAM:	PF14092	Sequences: IGSDLIPDDDFNINVTTDTTFTVTAYTVKLDSVQTSNLSTNLLGSYNDPVFGKTTASFYTQLRLPENSSNPDFGDNPVIDSVVLVLPYDSYYYGDTLAPQKLSVYELYFLEDLPNSFDEDSTYYSNFDPSKSYTLGDLTVPDSIRNVDTSTTVTTRLAPQIRIPLDDSFGQQKLLDKDGSSELSKNNDNFLNYFKGLYIKADSGDGALLYFNLSNSKLTIYYHYDTTDTTDTVDDTFDYEYDFSITSGVAQFNHFEHDYSGTPIANALLSNNNDSSKLYLQGGAGVYTKIDLPVDDIGDELKNDNILINKAELVFYVDNDTYDNSYPPSRLLLYDKDNNTPLNDFFEDNTLSDNTTSFLASYFGGTLDRDNDGTNTYYTFNITRYIQNLLNGDSTNVKNPDENLGLLLIPVSSTTSPLRTVLYGSNPGSTSGNPDKRLKLEIYYTK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	446 (424)
Sequences:	4674 (4259)
Seq/√Len:	206.8
META:	0.85

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
106_E	173_K	7.698	1.00
164_P	167_D	4.317	1.00
278_L	288_T	4.050	1.00
172_Q	176_D	3.579	1.00
80_D	221_Y	3.249	1.00
58_F	199_I	3.186	1.00
83_V	162_R	3.161	1.00
136_G	140_V	3.129	1.00
103_S	200_K	3.105	1.00
103_S	202_D	3.056	1.00
186_N	189_N	2.986	1.00
27_T	286_V	2.916	1.00
79_I	220_I	2.844	1.00
26_Y	289_K	2.719	1.00
82_V	170_G	2.712	1.00
420_T	423_Y	2.711	1.00
76_N	225_D	2.635	1.00
142_D	146_N	2.544	1.00
105_Y	200_K	2.520	1.00
82_V	220_I	2.481	1.00
312_E	379_T	2.350	1.00
136_G	139_T	2.305	1.00
177_K	182_E	2.305	1.00
101_K	202_D	2.297	1.00
25_A	278_L	2.265	1.00
83_V	164_P	2.255	1.00
64_L	187_N	2.245	1.00
405_G	408_L	2.234	1.00
85_V	160_Q	2.220	1.00
45_S	55_T	2.218	1.00
82_V	218_L	2.207	1.00
57_S	254_H	2.196	1.00
314_V	377_Y	2.191	1.00
419_R	422_L	2.138	1.00
85_V	219_T	2.131	1.00
312_E	441_E	2.124	1.00
82_V	169_F	2.118	1.00
25_A	290_I	2.107	1.00
70_N	73_F	2.105	1.00
137_D	141_P	2.098	1.00
112_D	195_K	2.091	1.00
174_L	183_L	2.075	1.00
344_D	348_D	2.061	1.00
424_G	428_G	2.056	1.00
57_S	198_Y	1.958	1.00
277_K	318_D	1.944	1.00
14_N	19_T	1.943	1.00
24_T	291_D	1.934	1.00
83_V	221_Y	1.923	1.00
113_L	117_F	1.903	1.00
61_Q	191_L	1.898	1.00
78_V	223_H	1.877	1.00
309_N	445_T	1.853	1.00
104_V	199_I	1.847	1.00
385_Y	389_L	1.843	1.00
143_S	146_N	1.827	1.00
315_F	438_L	1.821	1.00
310_K	381_N	1.793	1.00
43_L	58_F	1.770	1.00
7_P	10_D	1.748	1.00
280_L	331_L	1.746	1.00
181_S	184_S	1.714	1.00
13_I	18_D	1.707	1.00
314_V	441_E	1.703	1.00
14_N	18_D	1.676	1.00
95_D	98_A	1.673	1.00
47_N	53_K	1.670	1.00
189_N	192_N	1.665	1.00
169_F	194_F	1.660	1.00
13_I	19_T	1.657	1.00
18_D	22_T	1.617	1.00
25_A	438_L	1.617	1.00
133_Y	136_G	1.613	1.00
79_I	170_G	1.608	1.00
86_L	211_F	1.605	1.00
173_K	177_K	1.602	1.00
261_G	265_A	1.601	1.00
81_S	221_Y	1.597	1.00
45_S	53_K	1.594	1.00
289_K	336_K	1.575	1.00
308_I	311_A	1.573	1.00
177_K	193_Y	1.572	1.00
194_F	197_L	1.564	1.00
79_I	82_V	1.564	1.00
58_F	213_L	1.560	1.00
142_D	145_R	1.556	1.00
55_T	200_K	1.555	1.00
80_D	223_H	1.549	1.00
333_L	380_F	1.534	1.00
280_L	288_T	1.529	1.00
222_Y	225_D	1.526	1.00
43_L	102_L	1.493	1.00
308_I	442_I	1.486	1.00
299_D	302_K	1.483	1.00
301_L	304_D	1.475	1.00
167_D	170_G	1.474	1.00
138_L	141_P	1.466	1.00
55_T	256_E	1.466	1.00
32_S	126_N	1.458	1.00
341_P	344_D	1.455	1.00
118_D	121_S	1.443	1.00
30_L	287_Y	1.426	1.00
316_Y	377_Y	1.421	1.00
197_L	218_L	1.419	1.00
268_L	271_N	1.411	1.00
59_Y	107_L	1.398	1.00
100_Q	207_A	1.383	1.00
60_T	199_I	1.374	1.00
80_D	164_P	1.365	1.00
105_Y	198_Y	1.360	1.00
87_P	216_S	1.352	1.00
79_I	175_L	1.351	1.00
258_D	261_G	1.350	1.00
335_D	338_N	1.348	1.00
74_G	77_P	1.344	1.00
314_V	379_T	1.340	1.00
272_N	275_S	1.337	1.00
317_V	320_D	1.328	1.00
419_R	423_Y	1.325	1.00
271_N	275_S	1.324	1.00
88_Y	159_P	1.320	1.00
342_L	349_N	1.308	1.00
40_T	89_D	1.304	1.00
317_V	367_L	1.296	1.00
26_Y	291_D	1.295	1.00
301_L	305_N	1.289	1.00
177_K	180_S	1.288	1.00
368_D	377_Y	1.280	1.00
59_Y	254_H	1.277	1.00
417_P	420_T	1.270	1.00
161_I	211_F	1.268	1.00
357_S	360_A	1.268	1.00
59_Y	198_Y	1.264	1.00
54_T	257_H	1.263	1.00
41_N	58_F	1.258	1.00
259_Y	262_T	1.255	1.00
418_L	422_L	1.253	1.00
168_S	172_Q	1.252	1.00
61_Q	112_D	1.251	1.00
74_G	224_Y	1.251	1.00
278_L	438_L	1.246	1.00
245_I	251_Q	1.241	1.00
42_L	208_L	1.241	1.00
245_I	249_V	1.237	1.00
331_L	337_D	1.234	1.00
35_T	125_S	1.230	1.00
313_L	382_I	1.227	1.00
60_T	197_L	1.220	1.00
16_T	19_T	1.219	1.00
343_N	350_T	1.196	1.00
273_N	276_S	1.196	1.00
174_L	194_F	1.175	1.00
104_V	163_I	1.173	1.00
120_D	123_Y	1.173	1.00
106_E	195_K	1.171	1.00
271_N	276_S	1.170	1.00
42_L	283_G	1.169	1.00
165_L	218_L	1.168	1.00
79_I	167_D	1.166	1.00
136_G	141_P	1.164	1.00
270_S	273_N	1.162	1.00
53_K	258_D	1.159	1.00
267_A	270_S	1.156	1.00
405_G	410_P	1.150	1.00
84_L	104_V	1.150	1.00
63_R	191_L	1.146	1.00
343_N	348_D	1.138	1.00
177_K	183_L	1.132	1.00
57_S	200_K	1.132	1.00
130_S	133_Y	1.126	1.00
137_D	140_V	1.120	1.00
62_L	218_L	1.115	1.00
364_G	368_D	1.111	1.00
34_Q	122_T	1.110	1.00
28_V	289_K	1.110	1.00
245_I	250_A	1.107	1.00
117_F	123_Y	1.105	1.00
246_T	249_V	1.104	1.00
258_D	262_T	1.102	1.00
131_K	134_T	1.093	1.00
85_V	162_R	1.092	1.00
38_L	41_N	1.092	1.00
184_S	189_N	1.086	1.00
173_K	193_Y	1.086	1.00
270_S	274_D	1.082	1.00
358_F	361_S	1.082	1.00
198_Y	201_A	1.081	1.00
419_R	424_G	1.078	1.00
417_P	421_V	1.076	1.00
314_V	439_K	1.069	1.00
56_A	255_F	1.062	1.00
187_N	191_L	1.056	1.00
221_Y	224_Y	1.052	1.00
363_F	367_L	1.050	1.00
353_D	356_T	1.040	1.00
388_N	392_G	1.035	1.00
170_G	175_L	1.035	1.00
364_G	369_R	1.035	1.00
51_F	279_Y	1.032	1.00
18_D	21_F	1.027	1.00
365_G	369_R	1.025	1.00
406_L	409_I	1.022	1.00
318_D	321_T	1.008	1.00
343_N	347_E	1.008	1.00
212_N	215_N	1.004	1.00
227_T	231_D	1.000	1.00
313_L	440_L	0.995	1.00
149_T	152_T	0.992	1.00
142_D	148_D	0.988	1.00
417_P	423_Y	0.981	1.00
345_F	349_N	0.981	1.00
410_P	414_T	0.980	1.00
218_L	222_Y	0.975	1.00
264_I	268_L	0.975	1.00
174_L	220_I	0.972	1.00
77_P	224_Y	0.970	1.00
412_S	415_T	0.967	1.00
140_V	145_R	0.964	1.00
85_V	217_K	0.959	1.00
386_I	442_I	0.956	0.99
71_P	74_G	0.955	0.99
333_L	337_D	0.952	0.99
104_V	197_L	0.945	0.99
84_L	199_I	0.940	0.99
409_I	413_S	0.939	0.99
100_Q	201_A	0.939	0.99
268_L	272_N	0.938	0.99
290_I	313_L	0.937	0.99
263_P	266_N	0.937	0.99
364_G	367_L	0.936	0.99
438_L	441_E	0.935	0.99
19_T	22_T	0.928	0.99
62_L	197_L	0.925	0.99
144_I	147_V	0.925	0.99
3_S	6_I	0.924	0.99
80_D	83_V	0.923	0.99
264_I	267_A	0.921	0.99
342_L	348_D	0.921	0.99
168_S	173_K	0.920	0.99
31_D	126_N	0.917	0.99
41_N	213_L	0.917	0.99
104_V	165_L	0.916	0.99
331_L	334_Y	0.916	0.99
265_A	269_L	0.915	0.99
269_L	273_N	0.913	0.99
410_P	413_S	0.912	0.99
400_P	404_L	0.910	0.99
290_I	315_F	0.909	0.99
157_L	160_Q	0.907	0.99
219_T	242_D	0.901	0.99
68_S	71_P	0.898	0.99
270_S	275_S	0.896	0.99
107_L	113_L	0.896	0.99
267_A	279_Y	0.893	0.99
417_P	422_L	0.890	0.99
48_D	279_Y	0.889	0.99
81_S	164_P	0.888	0.99
221_Y	225_D	0.885	0.99
150_S	153_V	0.883	0.99
102_L	201_A	0.878	0.99
334_Y	337_D	0.878	0.99
319_N	322_Y	0.877	0.99
308_I	386_I	0.877	0.99
95_D	205_D	0.875	0.99
356_T	360_A	0.874	0.99
86_L	216_S	0.873	0.99
182_E	189_N	0.873	0.99
263_P	267_A	0.873	0.99
342_L	347_E	0.872	0.99
300_E	304_D	0.870	0.99
332_L	335_D	0.870	0.99
169_F	173_K	0.870	0.99
228_D	231_D	0.869	0.99
267_A	271_N	0.868	0.99
234_D	237_F	0.867	0.99
23_V	313_L	0.862	0.99
42_L	210_Y	0.860	0.99
348_D	352_S	0.859	0.99
308_I	390_L	0.859	0.99
311_A	386_I	0.856	0.99
82_V	165_L	0.855	0.99
355_T	358_F	0.853	0.99
315_F	408_L	0.852	0.99
426_N	429_S	0.852	0.99
151_T	154_T	0.851	0.99
132_S	135_L	0.851	0.99
91_Y	96_T	0.849	0.99
248_G	251_Q	0.847	0.99
25_A	288_T	0.845	0.99
433_N	436_K	0.842	0.99
167_D	172_Q	0.839	0.99
43_L	211_F	0.837	0.99
2_G	5_L	0.833	0.99
190_F	194_F	0.827	0.99
349_N	352_S	0.827	0.99
337_D	341_P	0.825	0.98
272_N	276_S	0.825	0.98
228_D	232_T	0.821	0.98
6_I	9_D	0.819	0.98
27_T	278_L	0.819	0.98
331_L	335_D	0.818	0.98
164_P	221_Y	0.817	0.98
42_L	253_N	0.815	0.98
343_N	346_F	0.815	0.98
267_A	275_S	0.813	0.98
302_K	305_N	0.808	0.98
341_P	348_D	0.808	0.98
418_L	421_V	0.807	0.98
59_Y	252_F	0.806	0.98
213_L	216_S	0.806	0.98
15_V	19_T	0.806	0.98
153_V	156_R	0.806	0.98
102_L	199_I	0.806	0.98
84_L	165_L	0.805	0.98
289_K	405_G	0.802	0.98
62_L	194_F	0.798	0.98
418_L	423_Y	0.798	0.98
210_Y	417_P	0.797	0.98
23_V	290_I	0.797	0.98
266_N	269_L	0.795	0.98
165_L	170_G	0.795	0.98
382_I	385_Y	0.793	0.98
243_F	246_T	0.793	0.98
434_P	437_R	0.792	0.98
22_T	293_P	0.792	0.98
77_P	175_L	0.792	0.98
402_E	405_G	0.792	0.98
389_L	392_G	0.789	0.98
346_F	349_N	0.789	0.98
368_D	371_N	0.788	0.98
102_L	161_I	0.783	0.98
343_N	349_N	0.782	0.98
269_L	272_N	0.780	0.98
387_Q	391_N	0.780	0.98
345_F	351_L	0.780	0.98
267_A	276_S	0.777	0.98
22_T	298_G	0.777	0.98
143_S	148_D	0.775	0.98
427_P	430_T	0.775	0.98
148_D	152_T	0.771	0.98
259_Y	286_V	0.769	0.98
271_N	274_D	0.769	0.98
106_E	169_F	0.766	0.98
207_A	211_F	0.766	0.98
56_A	208_L	0.765	0.98
230_T	234_D	0.764	0.98
178_D	182_E	0.763	0.98
176_D	179_G	0.763	0.98
112_D	192_N	0.763	0.98
317_V	322_Y	0.762	0.97
348_D	351_L	0.761	0.97
425_S	428_G	0.758	0.97
13_I	16_T	0.756	0.97
45_S	201_A	0.756	0.97
170_G	173_K	0.755	0.97
28_V	287_Y	0.752	0.97
399_N	402_E	0.750	0.97
330_R	333_L	0.747	0.97
12_N	15_V	0.746	0.97
138_L	142_D	0.744	0.97
169_F	174_L	0.743	0.97
229_T	232_T	0.742	0.97
332_L	337_D	0.740	0.97
82_V	167_D	0.739	0.97
266_N	270_S	0.735	0.97
145_R	149_T	0.734	0.97
57_S	201_A	0.734	0.97
98_A	205_D	0.732	0.97
86_L	163_I	0.730	0.97
401_D	410_P	0.730	0.97
68_S	73_F	0.727	0.97
365_G	372_D	0.726	0.97
338_N	341_P	0.723	0.97
295_D	298_G	0.722	0.97
307_L	387_Q	0.722	0.97
340_T	343_N	0.722	0.97
424_G	429_S	0.721	0.96
306_I	387_Q	0.720	0.96
344_D	347_E	0.716	0.96
420_T	425_S	0.712	0.96
145_R	148_D	0.711	0.96
331_L	380_F	0.710	0.96
267_A	274_D	0.710	0.96
150_S	154_T	0.709	0.96
148_D	151_T	0.708	0.96
407_L	410_P	0.708	0.96
90_S	210_Y	0.707	0.96
12_N	16_T	0.707	0.96
341_P	346_F	0.706	0.96
262_T	265_A	0.706	0.96
57_S	199_I	0.704	0.96
119_E	125_S	0.702	0.96
149_T	153_V	0.702	0.96
264_I	270_S	0.700	0.96
322_Y	325_S	0.700	0.96
246_T	250_A	0.699	0.96
356_T	359_L	0.699	0.96
152_T	155_T	0.699	0.96
133_Y	137_D	0.698	0.96
147_V	150_S	0.695	0.96
175_L	179_G	0.693	0.96
345_F	348_D	0.692	0.96
226_T	231_D	0.692	0.96
88_Y	161_I	0.688	0.95
255_F	283_G	0.687	0.95
416_S	419_R	0.686	0.95
130_S	135_L	0.685	0.95
136_G	145_R	0.684	0.95
91_Y	210_Y	0.683	0.95
342_L	350_T	0.682	0.95
267_A	272_N	0.682	0.95
46_Y	54_T	0.681	0.95
421_V	424_G	0.679	0.95
342_L	346_F	0.678	0.95
229_T	233_V	0.677	0.95
34_Q	37_N	0.676	0.95
176_D	180_S	0.676	0.95
249_V	252_F	0.675	0.95
55_T	258_D	0.675	0.95
247_S	250_A	0.675	0.95
424_G	427_P	0.674	0.95
136_G	142_D	0.672	0.95
82_V	164_P	0.671	0.95
107_L	110_L	0.669	0.95
140_V	144_I	0.669	0.95
129_P	133_Y	0.668	0.95
263_P	268_L	0.666	0.95
372_D	375_N	0.665	0.95
219_T	222_Y	0.662	0.94
87_P	215_N	0.661	0.94
131_K	135_L	0.659	0.94
405_G	409_I	0.659	0.94
172_Q	175_L	0.658	0.94
166_D	172_Q	0.657	0.94
384_R	387_Q	0.656	0.94
319_N	376_T	0.656	0.94
422_L	425_S	0.656	0.94
299_D	303_N	0.653	0.94
106_E	110_L	0.652	0.94
69_S	187_N	0.650	0.94
421_V	425_S	0.648	0.94
369_R	372_D	0.646	0.94
122_T	126_N	0.645	0.94
144_I	148_D	0.645	0.94
206_G	209_L	0.645	0.94
256_E	259_Y	0.642	0.93
350_T	353_D	0.641	0.93
354_N	357_S	0.641	0.93
133_Y	138_L	0.638	0.93
64_L	69_S	0.637	0.93
324_N	327_P	0.636	0.93
89_D	210_Y	0.636	0.93
346_F	350_T	0.634	0.93
266_N	272_N	0.634	0.93
357_S	361_S	0.633	0.93
385_Y	388_N	0.633	0.93
230_T	235_D	0.629	0.93
80_D	162_R	0.629	0.93
130_S	136_G	0.629	0.93
265_A	268_L	0.628	0.93
260_S	265_A	0.628	0.93
384_R	388_N	0.628	0.93
41_N	251_Q	0.627	0.93
8_D	13_I	0.627	0.93
244_S	249_V	0.626	0.93
335_D	341_P	0.625	0.93
228_D	234_D	0.624	0.92
50_V	279_Y	0.623	0.92
427_P	433_N	0.623	0.92
405_G	411_V	0.623	0.92
257_H	260_S	0.622	0.92
21_F	24_T	0.620	0.92
88_Y	207_A	0.616	0.92
131_K	137_D	0.616	0.92
354_N	358_F	0.616	0.92
332_L	336_K	0.616	0.92
432_G	436_K	0.616	0.92
54_T	255_F	0.616	0.92
317_V	321_T	0.615	0.92
288_T	291_D	0.614	0.92
368_D	376_T	0.614	0.92
81_S	223_H	0.613	0.92
367_L	370_D	0.612	0.92
159_P	162_R	0.611	0.92
103_S	315_F	0.610	0.92
207_A	210_Y	0.609	0.92
402_E	406_L	0.609	0.92
105_Y	202_D	0.609	0.92
54_T	281_Q	0.608	0.91
125_S	284_A	0.607	0.91
425_S	429_S	0.606	0.91
257_H	281_Q	0.604	0.91
261_G	264_I	0.603	0.91
231_D	234_D	0.603	0.91
83_V	219_T	0.602	0.91
423_Y	426_N	0.602	0.91
35_T	252_F	0.601	0.91
48_D	419_R	0.601	0.91
290_I	333_L	0.601	0.91
269_L	274_D	0.601	0.91
347_E	357_S	0.600	0.91
93_Y	210_Y	0.600	0.91
264_I	269_L	0.600	0.91
283_G	380_F	0.595	0.91
142_D	152_T	0.594	0.91
86_L	161_I	0.594	0.91
420_T	424_G	0.593	0.90
282_G	334_Y	0.591	0.90
88_Y	190_F	0.591	0.90
154_T	157_L	0.590	0.90
8_D	16_T	0.588	0.90
411_V	414_T	0.585	0.90
424_G	430_T	0.585	0.90
23_V	292_L	0.585	0.90
300_E	303_N	0.585	0.90
330_R	334_Y	0.579	0.89
422_L	429_S	0.579	0.89
233_V	236_T	0.577	0.89
248_G	252_F	0.576	0.89
60_T	64_L	0.574	0.89
232_T	237_F	0.573	0.89
225_D	229_T	0.573	0.89
265_A	270_S	0.572	0.89
230_T	237_F	0.571	0.89
132_S	138_L	0.570	0.89
383_T	390_L	0.570	0.89
40_T	210_Y	0.570	0.89
170_G	180_S	0.569	0.89
278_L	315_F	0.568	0.88
71_P	174_L	0.568	0.88
398_K	401_D	0.565	0.88
259_Y	281_Q	0.565	0.88
319_N	323_D	0.565	0.88
181_S	189_N	0.564	0.88
358_F	362_Y	0.563	0.88
308_I	444_Y	0.562	0.88
21_F	292_L	0.561	0.88
7_P	12_N	0.561	0.88
179_G	189_N	0.560	0.88
279_Y	370_D	0.559	0.88
147_V	151_T	0.559	0.88
142_D	147_V	0.558	0.88
300_E	305_N	0.558	0.88
70_N	75_D	0.557	0.88
47_N	205_D	0.556	0.87
316_Y	376_T	0.554	0.87
12_N	18_D	0.552	0.87
386_I	390_L	0.552	0.87
432_G	435_D	0.552	0.87
61_Q	250_A	0.551	0.87
415_T	418_L	0.551	0.87
135_L	140_V	0.550	0.87
264_I	272_N	0.549	0.87
233_V	237_F	0.549	0.87
318_D	423_Y	0.548	0.87
333_L	336_K	0.547	0.87
423_Y	427_P	0.547	0.87
169_F	204_G	0.544	0.86
289_K	407_L	0.543	0.86
216_S	219_T	0.543	0.86
268_L	273_N	0.543	0.86
12_N	17_T	0.543	0.86
316_Y	436_K	0.542	0.86
399_N	403_N	0.541	0.86
139_T	145_R	0.541	0.86
139_T	142_D	0.541	0.86
147_V	154_T	0.541	0.86
293_P	380_F	0.541	0.86
151_T	155_T	0.539	0.86
264_I	274_D	0.539	0.86
141_P	145_R	0.538	0.86
117_F	124_Y	0.537	0.86
73_F	77_P	0.536	0.85
383_T	387_Q	0.536	0.85
319_N	324_N	0.535	0.85
355_T	360_A	0.534	0.85
17_T	168_S	0.534	0.85
60_T	216_S	0.533	0.85
142_D	149_T	0.533	0.85
255_F	284_A	0.532	0.85
111_E	121_S	0.532	0.85
135_L	141_P	0.532	0.85
316_Y	319_N	0.531	0.85
329_S	332_L	0.531	0.85
344_D	349_N	0.531	0.85
173_K	176_D	0.530	0.85
269_L	275_S	0.530	0.85
322_Y	326_Y	0.530	0.85
178_D	181_S	0.530	0.85
428_G	432_G	0.528	0.85
63_R	187_N	0.528	0.85
104_V	191_L	0.527	0.85
146_N	149_T	0.527	0.85
84_L	197_L	0.526	0.84
218_L	224_Y	0.526	0.84
180_S	183_L	0.525	0.84
347_E	350_T	0.523	0.84
426_N	430_T	0.523	0.84
32_S	124_Y	0.523	0.84
320_D	327_P	0.523	0.84
217_K	242_D	0.522	0.84
435_D	440_L	0.522	0.84
263_P	276_S	0.522	0.84
175_L	220_I	0.520	0.84
278_L	286_V	0.519	0.84
32_S	35_T	0.519	0.84
48_D	281_Q	0.517	0.83
173_K	178_D	0.517	0.83
8_D	14_N	0.517	0.83
341_P	350_T	0.516	0.83
363_F	369_R	0.516	0.83
225_D	230_T	0.515	0.83
85_V	157_L	0.515	0.83
346_F	351_L	0.515	0.83
247_S	251_Q	0.514	0.83
78_V	221_Y	0.513	0.83
83_V	167_D	0.513	0.83
246_T	251_Q	0.512	0.83
65_P	190_F	0.511	0.83
79_I	164_P	0.510	0.83
329_S	337_D	0.510	0.83
24_T	28_V	0.510	0.83
187_N	190_F	0.510	0.83
112_D	191_L	0.509	0.82
128_D	254_H	0.509	0.82
216_S	222_Y	0.508	0.82
297_I	386_I	0.506	0.82
79_I	309_N	0.505	0.82
144_I	150_S	0.505	0.82
360_A	365_G	0.504	0.82
134_T	138_L	0.503	0.82
359_L	364_G	0.502	0.82
123_Y	126_N	0.501	0.81
73_F	178_D	0.501	0.81
367_L	371_N	0.500	0.81
411_V	415_T	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cbuG	1	0.2601	8.3	0.969	Contact Map
2vikA	1	0.2646	7.1	0.97	Contact Map
3glwZ	2	0.0381	2.4	0.976	Contact Map
1t44G	1	0.3027	1.4	0.979	Contact Map
2mdvA	2	0.0852	1.3	0.979	Contact Map
2r0jA	1	0.1278	0.9	0.982	Contact Map
2fo3A	1	0.1233	0.8	0.982	Contact Map
3fm7C	1	0.0493	0.8	0.982	Contact Map
1m45B	1	0.0561	0.7	0.983	Contact Map
1bazA	4	0.1121	0.7	0.983	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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