GREMLIN Database
DUF4268 - Domain of unknown function (DUF4268)
PFAM: PF14088 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 140 (138)
Sequences: 7877 (6585)
Seq/√Len: 560.6
META: 0.907

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_A122_I3.4751.00
4_E115_E3.4091.00
73_E76_K2.9341.00
70_D91_R2.8561.00
133_E137_K2.7281.00
75_L139_Y2.5651.00
117_D120_E2.4281.00
5_F125_L2.2061.00
75_L78_E2.1641.00
44_F129_M2.1081.00
12_Y122_I2.1051.00
76_K80_E2.0711.00
35_T42_L2.0121.00
128_R131_K1.9021.00
56_Y97_A1.8151.00
12_Y123_E1.7981.00
85_E128_R1.7871.00
45_V52_R1.7811.00
115_E118_W1.7121.00
127_E131_K1.6721.00
57_I68_I1.6591.00
47_N50_K1.6501.00
114_D117_D1.6361.00
70_D73_E1.5691.00
37_I40_F1.5671.00
82_E139_Y1.5591.00
5_F121_I1.5461.00
80_E86_E1.5121.00
59_R64_E1.4741.00
44_F125_L1.4711.00
58_D96_K1.4541.00
78_E82_E1.4481.00
117_D121_I1.4431.00
67_E71_Q1.4301.00
40_F68_I1.4011.00
82_E138_P1.3831.00
110_V121_I1.3701.00
85_E102_R1.3371.00
9_F44_F1.3061.00
51_A121_I1.2951.00
43_S54_E1.2941.00
85_E131_K1.2921.00
3_L7_T1.2901.00
71_Q74_A1.2901.00
53_V132_F1.2891.00
123_E127_E1.2771.00
66_K70_D1.2771.00
83_F102_R1.2731.00
32_N43_S1.2731.00
12_Y126_I1.2601.00
88_E101_S1.2401.00
66_K91_R1.2351.00
47_N52_R1.2351.00
90_E101_S1.2301.00
83_F87_L1.2231.00
59_R68_I1.2121.00
102_R128_R1.1731.00
131_K134_K1.1611.00
45_V54_E1.1611.00
3_L27_P1.1531.00
32_N41_H1.1081.00
66_K98_S1.1081.00
69_F73_E1.0991.00
33_Y44_F1.0951.00
12_Y16_K1.0931.00
92_L95_K1.0921.00
10_L14_K1.0921.00
90_E99_R1.0861.00
126_I130_I1.0831.00
8_A118_W1.0541.00
57_I72_L1.0481.00
130_I134_K1.0231.00
130_I133_E1.0041.00
64_E68_I0.9961.00
92_L99_R0.9921.00
82_E135_A0.9871.00
12_Y15_E0.9751.00
83_F135_A0.9721.00
124_W128_R0.9701.00
122_I125_L0.9701.00
8_A119_P0.9701.00
77_E81_K0.9641.00
71_Q75_L0.9601.00
121_I125_L0.9501.00
119_P123_E0.9491.00
9_F122_I0.9401.00
83_F131_K0.9351.00
4_E8_A0.9261.00
9_F13_L0.9251.00
7_T11_E0.9251.00
51_A125_L0.9231.00
82_E134_K0.9221.00
87_L132_F0.9101.00
33_Y129_M0.9061.00
46_F112_I0.8871.00
12_Y119_P0.8601.00
2_R28_Q0.8521.00
107_L110_V0.8411.00
92_L97_A0.8401.00
6_W9_F0.8341.00
54_E99_R0.8321.00
43_S56_Y0.8221.00
8_A11_E0.8211.00
64_E67_E0.8131.00
48_K51_A0.8121.00
83_F128_R0.8121.00
69_F89_W0.8081.00
80_E87_L0.7941.00
91_R98_S0.7901.00
118_W122_I0.7871.00
50_K103_I0.7831.00
16_K130_I0.7811.00
29_N45_V0.7791.00
13_L126_I0.7631.00
10_L31_I0.7611.00
6_W125_L0.7581.00
23_R31_I0.7581.00
4_E7_T0.7501.00
8_A12_Y0.7501.00
84_G131_K0.7491.00
42_L137_K0.7471.00
17_T20_F0.7461.00
17_T130_I0.7401.00
78_E81_K0.7371.00
35_T40_F0.7361.00
62_K66_K0.7281.00
19_L133_E0.7211.00
13_L20_F0.7181.00
7_T25_P0.7151.00
42_L129_M0.7141.00
80_E84_G0.7091.00
35_T55_L0.6961.00
122_I126_I0.6881.00
84_G87_L0.6851.00
9_F12_Y0.6841.00
20_F44_F0.6811.00
2_R27_P0.6801.00
51_A124_W0.6731.00
34_S38_S0.6701.00
76_K89_W0.6681.00
52_R103_I0.6571.00
73_E91_R0.6561.00
16_K127_E0.6531.00
112_I121_I0.6531.00
78_E139_Y0.6431.00
104_Y124_W0.6431.00
79_I135_A0.6411.00
104_Y120_E0.6351.00
54_E101_S0.6291.00
92_L98_S0.6281.00
132_F136_F0.6271.00
77_E80_E0.6251.00
70_D93_D0.6211.00
59_R65_N0.6201.00
94_D98_S0.6181.00
37_I68_I0.6171.00
49_K111_D0.6151.00
11_E14_K0.6091.00
107_L120_E0.6071.00
58_D97_A0.5941.00
3_L25_P0.5931.00
111_D114_D0.5931.00
13_L129_M0.5931.00
2_R26_S0.5891.00
7_T10_L0.5891.00
120_E124_W0.5821.00
123_E126_I0.5791.00
131_K135_A0.5771.00
42_L133_E0.5771.00
40_F57_I0.5740.99
40_F55_L0.5720.99
16_K123_E0.5710.99
39_G65_N0.5660.99
73_E77_E0.5640.99
50_K106_E0.5620.99
128_R132_F0.5590.99
120_E123_E0.5560.99
76_K79_I0.5550.99
53_V128_R0.5530.99
70_D74_A0.5520.99
80_E89_W0.5520.99
127_E134_K0.5510.99
135_A139_Y0.5490.99
23_R32_N0.5410.99
55_L136_F0.5400.99
58_D65_N0.5400.99
9_F129_M0.5390.99
60_G96_K0.5380.99
121_I124_W0.5350.99
68_I71_Q0.5340.99
83_F132_F0.5320.99
61_D64_E0.5320.99
44_F53_V0.5230.99
95_K98_S0.5210.99
79_I89_W0.5180.99
136_F139_Y0.5170.99
79_I87_L0.5150.99
10_L13_L0.5150.99
34_S37_I0.5110.99
9_F125_L0.5110.99
13_L22_N0.5110.99
28_Q32_N0.5100.99
23_R33_Y0.5090.99
17_T22_N0.5060.99
2_R46_F0.5030.99
125_L129_M0.5020.99
4_E118_W0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mc8A 1 0.3929 3.9 0.916 Contact Map
4exbA 2 0.5071 2.8 0.922 Contact Map
3odnA 1 0.5357 2.6 0.923 Contact Map
3zqsA 3 0.6857 2.5 0.924 Contact Map
4a1nA 2 0.9714 2.1 0.927 Contact Map
4e1pA 2 0.2929 1.7 0.93 Contact Map
3sscA 1 0.9143 1.7 0.93 Contact Map
4pqzA 1 0.5786 1.7 0.931 Contact Map
1di1A 1 0.9357 1.7 0.931 Contact Map
1dosA 2 0.3929 1.6 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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