GREMLIN Database
DUF4267 - Domain of unknown function (DUF4267)
PFAM: PF14087 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 112 (107)
Sequences: 2656 (1743)
Seq/√Len: 168.5
META: 0.777

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_V79_G5.4331.00
81_A99_G4.0761.00
14_A17_A3.6001.00
5_I51_G3.4861.00
11_F44_G3.3311.00
53_L69_V2.8671.00
49_A76_I2.7201.00
62_D65_A2.5421.00
67_G109_G2.2571.00
101_T105_M2.1371.00
22_F42_V2.1151.00
54_L69_V2.0131.00
5_I48_I1.8351.00
10_R18_A1.8161.00
97_I101_T1.7991.00
50_S76_I1.6061.00
10_R14_A1.5581.00
49_A75_L1.5061.00
96_G100_A1.4981.00
90_S93_A1.4921.00
77_P98_H1.4761.00
91_K95_L1.4741.00
99_G103_V1.4571.00
107_V111_L1.3401.00
19_A24_L1.3271.00
88_G92_A1.2811.00
43_K50_S1.2681.00
56_A68_W1.2661.00
60_A68_W1.2661.00
51_G55_L1.2631.00
49_A73_A1.2631.00
16_R20_A1.2281.00
43_K47_D1.2251.00
4_I50_S1.2191.00
1_G51_G1.1951.00
18_A21_G1.1591.00
55_L59_A1.1481.00
77_P102_A1.1461.00
6_A10_R1.1411.00
11_F18_A1.1341.00
4_I43_K1.1311.00
38_A87_H1.0961.00
108_V111_L1.0911.00
35_A38_A1.0881.00
71_L109_G1.0711.00
43_K101_T1.0590.99
100_A104_V1.0450.99
24_L38_A1.0230.99
46_R80_D1.0170.99
2_L55_L1.0020.99
4_I77_P0.9800.99
11_F40_L0.9540.99
67_G71_L0.9470.99
10_R17_A0.9350.99
82_L85_L0.9290.99
42_V81_A0.9100.98
24_L39_Y0.9080.98
17_A20_A0.9030.98
93_A97_I0.9010.98
78_L102_A0.9000.98
6_A9_A0.8900.98
94_A97_I0.8830.98
7_I18_A0.8780.98
32_P35_A0.8770.98
81_A100_A0.8740.98
37_R41_R0.8660.98
12_L48_I0.8410.97
67_G70_L0.8290.97
80_D86_R0.8210.97
11_F43_K0.8090.97
97_I102_A0.8060.97
8_G51_G0.7990.96
56_A72_A0.7990.96
64_R68_W0.7910.96
98_H105_M0.7890.96
15_P40_L0.7880.96
73_A76_I0.7820.96
57_L65_A0.7790.96
54_L66_L0.7790.96
17_A21_G0.7740.96
4_I44_G0.7630.95
19_A39_Y0.7500.95
2_L6_A0.7450.95
1_G65_A0.7440.95
79_G83_I0.7440.95
91_K94_A0.7410.95
23_G84_V0.7320.94
41_R87_H0.7270.94
6_A17_A0.7260.94
8_G44_G0.7240.94
2_L108_V0.7230.94
105_M111_L0.7150.94
39_Y43_K0.7110.93
47_D102_A0.7090.93
95_L98_H0.7070.93
85_L89_G0.7010.93
22_F83_I0.6940.92
86_R91_K0.6940.92
10_R21_G0.6910.92
21_G84_V0.6820.92
97_I105_M0.6480.90
3_G7_I0.6420.89
74_A78_L0.6360.89
92_A96_G0.6310.88
74_A77_P0.6300.88
3_G50_S0.6210.88
58_L66_L0.6210.88
72_A75_L0.6150.87
40_L43_K0.6130.87
56_A65_A0.6120.87
27_P32_P0.6100.87
94_A106_L0.6090.87
47_D101_T0.6070.86
104_V107_V0.6050.86
24_L43_K0.6050.86
1_G26_P0.6020.86
105_M109_G0.6010.86
7_I39_Y0.5980.86
69_V84_V0.5970.86
56_A59_A0.5970.86
21_G43_K0.5920.85
107_V110_L0.5910.85
76_I80_D0.5870.85
4_I51_G0.5850.84
89_G92_A0.5820.84
62_D68_W0.5810.84
27_P34_P0.5790.84
101_T104_V0.5780.84
43_K84_V0.5760.83
78_L82_L0.5750.83
4_I73_A0.5750.83
22_F44_G0.5690.83
12_L41_R0.5690.83
45_V83_I0.5640.82
87_H90_S0.5640.82
81_A95_L0.5630.82
95_L101_T0.5630.82
12_L44_G0.5620.82
42_V83_I0.5590.82
37_R40_L0.5550.81
11_F47_D0.5540.81
52_L56_A0.5540.81
16_R27_P0.5500.81
52_L72_A0.5500.81
18_A47_D0.5480.80
81_A91_K0.5420.80
74_A109_G0.5420.80
27_P35_A0.5350.79
16_R59_A0.5230.77
26_P33_D0.5220.77
48_I75_L0.5210.77
12_L86_R0.5180.77
94_A98_H0.5170.76
58_L67_G0.5080.75
21_G51_G0.5050.75
54_L91_K0.5040.75
105_M108_V0.5040.75
16_R32_P0.5040.75
7_I47_D0.5020.74
27_P33_D0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n7wA 2 0.7679 4 0.899 Contact Map
4kppA 1 0.2857 3.4 0.903 Contact Map
1nbwA 2 0.4732 2 0.914 Contact Map
3mcpA 2 0.4911 1.1 0.927 Contact Map
3zuxA 1 0.7321 1 0.928 Contact Map
2d0oA 2 0.4821 0.9 0.93 Contact Map
3k3fA 3 0.8214 0.9 0.93 Contact Map
4bx8A 1 0.25 0.8 0.933 Contact Map
1nfuB 1 0 0.8 0.933 Contact Map
3kl4B 1 0.1161 0.8 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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