GREMLIN Database
DUF4266 - Domain of unknown function (DUF4266)
PFAM: PF14086 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 50 (50)
Sequences: 8128 (3456)
Seq/√Len: 488.8
META: 0.969

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_E40_G4.1681.00
2_K5_E2.9231.00
8_R11_D2.7341.00
17_D23_A2.2151.00
21_L24_A2.1471.00
22_E26_E1.9961.00
27_E31_F1.9011.00
26_E29_V1.5561.00
10_A46_G1.4601.00
34_E38_G1.3811.00
28_H32_S1.3361.00
6_R10_A1.3331.00
31_F37_S1.3281.00
26_E30_Y1.2961.00
6_R9_L1.2841.00
38_G41_G1.2271.00
12_P15_Q1.2251.00
23_A27_E1.2211.00
7_G10_A1.2001.00
13_I16_L1.1931.00
22_E25_F1.1561.00
3_P6_R1.1551.00
7_G12_P1.1281.00
31_F40_G1.1181.00
23_A40_G1.1071.00
12_P18_R1.0971.00
19_D22_E1.0131.00
37_S42_V0.9951.00
16_L33_R0.9271.00
29_V32_S0.9141.00
33_R45_G0.9011.00
28_H48_G0.8761.00
24_A27_E0.8671.00
29_V33_R0.8381.00
28_H45_G0.8121.00
27_E30_Y0.7911.00
28_H50_N0.7791.00
13_I18_R0.7721.00
30_Y33_R0.7421.00
3_P28_H0.7381.00
5_E42_V0.7251.00
38_G43_G0.7051.00
15_Q18_R0.6981.00
46_G49_C0.6971.00
21_L26_E0.6901.00
41_G44_G0.6901.00
25_F48_G0.6851.00
11_D32_S0.6821.00
38_G42_V0.6741.00
18_R22_E0.6651.00
36_A39_G0.6571.00
23_A26_E0.6551.00
43_G50_N0.6521.00
5_E19_D0.6301.00
4_W32_S0.6241.00
25_F29_V0.6140.99
24_A31_F0.6120.99
12_P19_D0.6090.99
3_P10_A0.6060.99
15_Q20_P0.5980.99
24_A42_V0.5870.99
6_R30_Y0.5630.99
33_R50_N0.5510.99
7_G24_A0.5440.99
18_R21_L0.5380.99
4_W7_G0.5380.99
19_D23_A0.5310.98
9_L12_P0.5290.98
37_S40_G0.5270.98
25_F32_S0.5220.98
21_L29_V0.5190.98
8_R15_Q0.5160.98
24_A33_R0.5160.98
37_S44_G0.5000.98
11_D33_R0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3au7A 1 0.5 6.1 0.874 Contact Map
3n44F 1 0 5.9 0.874 Contact Map
3j4sA 6 0.64 5.2 0.877 Contact Map
4qc8A 6 0 4.9 0.879 Contact Map
1w5fA 2 0.28 4.8 0.88 Contact Map
4ywtA 1 0.74 4.7 0.88 Contact Map
1nwbA 1 0.6 3.9 0.885 Contact Map
1r94A 3 0.68 3.7 0.886 Contact Map
3cymA 1 0.38 3.6 0.887 Contact Map
2d2aA 2 0.78 3.3 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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