GREMLIN Database
DUF4265 - Domain of unknown function (DUF4265)
PFAM: PF14085 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (114)
Sequences: 3274 (2864)
Seq/√Len: 268.2
META: 0.878

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_N91_D4.8851.00
32_R44_E4.0361.00
6_E14_R3.4721.00
108_G114_W3.4461.00
13_Y33_A2.2471.00
6_E16_D2.2101.00
42_F45_V2.1001.00
30_V47_E2.0841.00
70_L80_Y1.9901.00
23_Y55_R1.9131.00
12_L30_V1.8731.00
26_A53_T1.8711.00
25_V42_F1.8641.00
4_W17_N1.8491.00
14_R30_V1.7891.00
15_L31_V1.7771.00
14_R28_G1.7611.00
12_L46_V1.6991.00
32_R43_R1.6261.00
71_D74_E1.5811.00
32_R46_V1.5081.00
13_Y40_L1.4821.00
20_F81_E1.4691.00
67_E71_D1.4591.00
16_D28_G1.4591.00
104_L108_G1.4531.00
20_F89_A1.4041.00
106_D110_E1.4031.00
7_P10_D1.3861.00
27_L91_D1.3381.00
9_G12_L1.3131.00
11_G32_R1.2801.00
12_L47_E1.2731.00
102_E106_D1.2491.00
107_E111_A1.2321.00
45_V48_R1.2291.00
2_T17_N1.2141.00
73_L90_V1.1971.00
18_I89_A1.1901.00
17_N20_F1.1611.00
78_C90_V1.1531.00
15_L25_V1.1501.00
54_I98_Y1.1501.00
51_N94_P1.1491.00
31_V42_F1.1481.00
18_I27_L1.1461.00
72_E104_L1.1221.00
97_D100_A1.1201.00
54_I92_V1.1101.00
8_L14_R1.1081.00
54_I102_E1.1051.00
103_D107_E1.0991.00
7_P11_G1.0751.00
70_L90_V1.0661.00
12_L32_R1.0561.00
57_I87_L1.0541.00
99_D103_D1.0511.00
72_E75_A1.0471.00
98_Y102_E1.0471.00
18_I53_T1.0371.00
3_L19_P1.0151.00
14_R47_E1.0091.00
79_S91_D1.0021.00
8_L30_V1.0011.00
100_A103_D0.9771.00
17_N81_E0.9761.00
50_G94_P0.9751.00
8_L12_L0.9401.00
3_L15_L0.9021.00
73_L78_C0.8921.00
21_F87_L0.8891.00
20_F87_L0.8871.00
78_C101_V0.8851.00
73_L101_V0.8521.00
5_A15_L0.8491.00
70_L74_E0.8451.00
103_D106_D0.8411.00
104_L107_E0.8401.00
71_D75_A0.8350.99
82_G88_L0.8290.99
55_R89_A0.8280.99
7_P13_Y0.8250.99
73_L105_L0.8240.99
33_A40_L0.8170.99
26_A50_G0.8160.99
108_G111_A0.7920.99
93_P96_V0.7800.99
5_A13_Y0.7760.99
55_R88_L0.7710.99
107_E110_E0.7630.99
5_A17_N0.7600.99
62_A65_E0.7590.99
69_L104_L0.7520.99
16_D27_L0.7510.99
5_A33_A0.7510.99
70_L88_L0.7470.99
110_E113_V0.7420.99
4_W81_E0.7420.99
68_E72_E0.7310.99
27_L51_N0.7310.99
72_E107_E0.7290.99
35_E38_G0.7260.99
106_D109_E0.7240.99
27_L79_S0.7230.99
27_L49_S0.7140.98
23_Y90_V0.7080.98
96_V100_A0.7000.98
34_D43_R0.7000.98
34_D38_G0.6980.98
53_T91_D0.6890.98
52_S102_E0.6870.98
63_D66_E0.6820.98
25_V31_V0.6810.98
18_I80_Y0.6800.98
36_D39_E0.6750.98
24_G48_R0.6650.97
26_A52_S0.6650.97
2_T7_P0.6440.97
99_D106_D0.6430.97
83_A86_R0.6420.97
76_L96_V0.6420.97
20_F82_G0.6410.97
65_E68_E0.6410.97
52_S92_V0.6380.97
76_L101_V0.6330.97
25_V45_V0.6250.96
99_D102_E0.6250.96
4_W20_F0.6240.96
73_L104_L0.6220.96
61_D86_R0.6220.96
54_I99_D0.6200.96
108_G113_V0.6160.96
102_E109_E0.6150.96
58_F65_E0.6080.96
18_I28_G0.5970.95
22_A25_V0.5950.95
9_G13_Y0.5920.95
92_V101_V0.5800.94
1_E4_W0.5770.94
83_A87_L0.5730.94
21_F83_A0.5710.94
30_V46_V0.5700.94
3_L42_F0.5610.93
26_A48_R0.5590.93
107_E113_V0.5570.93
57_I86_R0.5520.93
69_L114_W0.5480.93
56_V105_L0.5430.92
76_L104_L0.5420.92
90_V105_L0.5410.92
68_E71_D0.5390.92
35_E39_E0.5370.92
70_L82_G0.5330.92
4_W53_T0.5320.91
10_D63_D0.5300.91
16_D92_V0.5290.91
62_A66_E0.5260.91
10_D30_V0.5260.91
94_P97_D0.5240.91
25_V53_T0.5240.91
77_G93_P0.5210.91
56_V90_V0.5210.91
24_G55_R0.5210.91
33_A42_F0.5180.90
69_L113_V0.5130.90
60_D63_D0.5080.90
84_N87_L0.5080.90
98_Y106_D0.5070.89
5_A31_V0.5050.89
67_E87_L0.5050.89
13_Y31_V0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eo0A 2 0.8879 66.6 0.852 Contact Map
1hh1A 2 0.8621 35.9 0.877 Contact Map
4w4mA 1 0.5086 17.8 0.894 Contact Map
4qglA 1 0.569 16.3 0.896 Contact Map
1ucrA 2 0.4569 15.5 0.897 Contact Map
1yj7A 3 0.5431 14.8 0.898 Contact Map
4ckkA 2 0.9483 13.9 0.899 Contact Map
1zpvA 3 0.569 13.8 0.899 Contact Map
4wghA 1 0.8707 13.8 0.899 Contact Map
2wcwA 2 0.8534 13.5 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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