GREMLIN Database
PGDYG - PGDYG protein
PFAM: PF14083 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (99)
Sequences: 1024 (710)
Seq/√Len: 71.3
META: 0.939

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_M62_F4.2901.00
94_A98_A4.1031.00
15_P18_E3.0301.00
84_Y90_G2.7941.00
75_G78_G2.5721.00
66_L71_D2.5631.00
24_R28_D2.4161.00
96_I100_T2.4141.00
12_L22_V2.3981.00
3_N21_P2.1901.00
39_A42_E2.1231.00
32_E49_R2.0071.00
64_V81_L1.9451.00
5_Y11_I1.8501.00
53_V82_V1.7561.00
82_V92_V1.7281.00
66_L70_G1.6571.00
81_L91_V1.6050.99
58_M75_G1.5960.99
64_V92_V1.5150.99
30_K48_K1.4900.99
57_Q94_A1.4830.99
21_P48_K1.4340.99
16_T96_I1.4250.99
18_E21_P1.3590.98
20_W73_L1.3370.98
62_F75_G1.3330.98
28_D40_A1.2480.97
97_F101_Y1.2440.96
26_R29_A1.2210.96
32_E47_R1.1620.95
66_L69_G1.1530.95
75_G91_V1.1500.95
21_P96_I1.1240.94
62_F81_L1.1230.94
57_Q80_W1.1160.94
14_G18_E1.0930.93
35_P38_T1.0890.93
3_N66_L1.0730.92
73_L78_G1.0600.92
83_Q89_Y1.0600.92
20_W75_G1.0590.92
21_P52_P1.0370.91
6_R25_E1.0340.91
33_P46_Y1.0290.90
83_Q86_P1.0060.89
22_V46_Y0.9950.89
63_S74_H0.9840.88
51_I76_K0.9740.88
44_G80_W0.9600.87
45_A59_D0.9520.87
2_P18_E0.9510.87
90_G96_I0.9440.86
22_V30_K0.9360.86
39_A45_A0.9230.85
10_A44_G0.9190.85
85_G90_G0.9050.84
10_A22_V0.9030.84
87_G91_V0.8960.83
93_A96_I0.8910.83
33_P44_G0.8880.83
20_W30_K0.8880.83
76_K93_A0.8870.83
52_P60_E0.8860.83
21_P64_V0.8820.82
33_P38_T0.8680.81
65_A72_L0.8590.81
10_A24_R0.8430.79
23_S26_R0.8040.76
85_G89_Y0.8030.76
10_A46_Y0.8010.76
73_L96_I0.7950.75
92_V100_T0.7930.75
95_A99_Q0.7830.74
16_T49_R0.7790.74
3_N48_K0.7680.73
16_T93_A0.7680.73
29_A54_L0.7430.70
58_M81_L0.7380.70
79_D91_V0.7340.69
11_I62_F0.7340.69
26_R30_K0.7280.69
78_G94_A0.7210.68
69_G72_L0.7190.68
94_A99_Q0.7170.67
3_N96_I0.7170.67
75_G81_L0.7160.67
93_A99_Q0.6950.65
34_V45_A0.6900.64
14_G20_W0.6880.64
10_A84_Y0.6870.64
58_M91_V0.6870.64
40_A82_V0.6790.63
57_Q78_G0.6770.63
32_E40_A0.6750.63
16_T99_Q0.6740.63
33_P40_A0.6720.62
68_D71_D0.6720.62
27_F90_G0.6640.61
61_P74_H0.6620.61
83_Q88_D0.6530.60
16_T69_G0.6510.60
36_P81_L0.6380.58
75_G80_W0.6380.58
35_P60_E0.6340.58
4_R49_R0.6270.57
11_I35_P0.6200.56
22_V27_F0.6020.54
46_Y55_A0.6010.54
2_P60_E0.5980.54
10_A13_T0.5980.54
39_A43_D0.5910.53
39_A59_D0.5890.52
32_E35_P0.5870.52
53_V58_M0.5830.52
35_P39_A0.5830.52
10_A28_D0.5830.52
76_K94_A0.5820.52
12_L19_R0.5820.52
25_E28_D0.5750.51
6_R36_P0.5710.50
42_E76_K0.5700.50
59_D72_L0.5690.50
20_W84_Y0.5660.50
48_K91_V0.5660.50
57_Q93_A0.5650.50
73_L91_V0.5610.49
7_A45_A0.5540.48
13_T17_G0.5480.47
38_T46_Y0.5460.47
82_V100_T0.5450.47
30_K51_I0.5440.47
2_P82_V0.5430.47
18_E64_V0.5410.47
13_T18_E0.5380.46
77_A80_W0.5320.45
50_P59_D0.5320.45
4_R7_A0.5320.45
50_P80_W0.5290.45
44_G47_R0.5260.45
48_K71_D0.5230.44
28_D47_R0.5190.44
2_P12_L0.5190.44
54_L57_Q0.5150.43
9_D23_S0.5090.43
49_R77_A0.5080.43
15_P51_I0.5050.42
84_Y88_D0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1eybA 5 0.8039 9.2 0.922 Contact Map
3es4A 2 0.3431 6.3 0.928 Contact Map
4maqA 2 0.4412 5.7 0.93 Contact Map
2a6hD 1 0.902 5 0.932 Contact Map
2riqA 2 0.4118 4.4 0.933 Contact Map
3c9iA 5 0.402 4.3 0.934 Contact Map
2eb4A 5 0.4118 4.1 0.934 Contact Map
1hqmD 1 0.8725 3.9 0.935 Contact Map
2a7yA 1 0.2941 3.7 0.935 Contact Map
2ecdA 1 0.5882 3.7 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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