GREMLIN Database
DUF4262 - Domain of unknown function (DUF4262)
PFAM: PF14081 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 125 (123)
Sequences: 4560 (3659)
Seq/√Len: 329.9
META: 0.889

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_L106_A3.6241.00
24_T50_L3.2181.00
11_G22_A2.9661.00
28_W105_P2.9431.00
56_R61_E2.7861.00
33_H57_V2.7351.00
22_A46_A2.6801.00
7_W54_A2.3841.00
27_L54_A2.2001.00
15_D18_G2.1891.00
70_D77_P2.1431.00
9_V22_A2.1051.00
10_Q25_I2.0971.00
51_N54_A2.0901.00
110_V120_W2.0831.00
94_W97_W1.9401.00
36_L109_L1.7991.00
7_W51_N1.7921.00
11_G43_P1.7711.00
68_R77_P1.7631.00
79_E120_W1.7551.00
25_I95_A1.7281.00
37_I92_L1.7041.00
53_V109_L1.6731.00
9_V47_H1.6181.00
117_R123_G1.6141.00
113_D117_R1.5531.00
82_P105_P1.5371.00
9_V51_N1.4901.00
47_H51_N1.4841.00
96_L104_F1.4781.00
68_R79_E1.4201.00
31_F58_R1.4071.00
84_D87_W1.3531.00
80_F109_L1.3391.00
64_E67_E1.2681.00
28_W32_G1.2581.00
65_P81_R1.2331.00
11_G47_H1.2231.00
36_L53_V1.2231.00
14_G20_P1.2161.00
39_F91_Y1.1961.00
48_G52_E1.1821.00
12_V23_Y1.1611.00
69_Y80_F1.1611.00
87_W90_E1.1541.00
96_L102_D1.1391.00
81_R110_V1.1331.00
73_L78_V1.1261.00
31_F54_A1.0881.00
65_P82_P1.0851.00
29_E98_F1.0711.00
82_P107_L1.0431.00
113_D124_F1.0391.00
66_G81_R1.0311.00
88_Y92_L1.0291.00
43_P46_A1.0201.00
87_W91_Y1.0151.00
38_V46_A0.9981.00
15_D19_P0.9871.00
41_L111_W0.9821.00
52_E56_R0.9821.00
27_L36_L0.9791.00
54_A58_R0.9761.00
117_R121_E0.9651.00
63_F80_F0.9631.00
37_I106_A0.9581.00
85_P103_D0.9571.00
52_E55_E0.9411.00
2_I98_F0.9191.00
21_F87_W0.9161.00
53_V56_R0.9111.00
73_L76_F0.9081.00
69_Y72_L0.9081.00
77_P116_G0.9071.00
45_L49_L0.9061.00
76_F112_P0.9031.00
76_F116_G0.8961.00
5_H51_N0.8801.00
9_V54_A0.8621.00
36_L107_L0.8531.00
27_L31_F0.8511.00
14_G18_G0.8501.00
85_P88_Y0.8381.00
13_F16_E0.8321.00
88_Y93_G0.8191.00
46_A49_L0.8161.00
83_V92_L0.7991.00
93_G96_L0.7911.00
14_G19_P0.7911.00
55_E58_R0.7911.00
41_L45_L0.7841.00
111_W124_F0.7681.00
95_A104_F0.7601.00
45_L48_G0.7581.00
10_Q13_F0.7540.99
74_E77_P0.7480.99
23_Y94_W0.7410.99
96_L101_G0.7390.99
42_P45_L0.7290.99
11_G46_A0.7270.99
118_F124_F0.7250.99
118_F121_E0.7230.99
27_L33_H0.7130.99
37_I91_Y0.7090.99
93_G97_W0.7050.99
24_T27_L0.7020.99
21_F37_I0.7000.99
65_P68_R0.6940.99
36_L50_L0.6890.99
10_Q94_W0.6890.99
37_I83_V0.6880.99
25_I94_W0.6880.99
65_P107_L0.6870.99
36_L57_V0.6840.99
21_F91_Y0.6740.99
9_V50_L0.6670.99
63_F67_E0.6660.99
35_E106_A0.6630.99
78_V109_L0.6570.99
3_E29_E0.6570.99
79_E118_F0.6540.99
53_V80_F0.6530.99
53_V72_L0.6520.99
33_H63_F0.6510.99
27_L50_L0.6470.98
38_V49_L0.6430.98
83_V106_A0.6390.98
41_L49_L0.6350.98
41_L46_A0.6270.98
83_V87_W0.6210.98
51_N55_E0.6160.98
88_Y105_P0.6150.98
42_P46_A0.6150.98
88_Y104_F0.6130.98
29_E99_Y0.6120.98
30_T58_R0.6110.98
92_L96_L0.6060.98
24_T36_L0.6050.98
40_G111_W0.6050.98
112_P116_G0.6040.98
50_L53_V0.6010.98
95_A99_Y0.6000.97
7_W24_T0.6000.97
60_G63_F0.5990.97
63_F69_Y0.5950.97
43_P47_H0.5940.97
53_V69_Y0.5930.97
55_E59_A0.5920.97
68_R121_E0.5910.97
54_A57_V0.5870.97
67_E107_L0.5860.97
56_R59_A0.5840.97
35_E95_A0.5820.97
39_F111_W0.5800.97
96_L103_D0.5790.97
13_F17_E0.5750.97
99_Y104_F0.5730.97
117_R122_P0.5690.97
14_G17_E0.5680.97
10_Q23_Y0.5670.96
7_W27_L0.5610.96
6_G58_R0.5580.96
36_L80_F0.5580.96
85_P89_R0.5580.96
81_R84_D0.5550.96
33_H62_R0.5540.96
101_G104_F0.5510.96
65_P69_Y0.5510.96
72_L78_V0.5490.96
8_H25_I0.5460.96
49_L73_L0.5430.96
92_L95_A0.5370.95
56_R63_F0.5370.95
27_L35_E0.5220.94
33_H53_V0.5220.94
111_W118_F0.5180.94
45_L76_F0.5150.94
61_E67_E0.5130.94
89_R96_L0.5120.94
36_L63_F0.5120.94
46_A50_L0.5090.94
66_G82_P0.5000.93
83_V93_G0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o8bB 1 0.24 20.7 0.907 Contact Map
3k5jA 1 0.92 9.3 0.921 Contact Map
1vcoA 4 0.432 5.2 0.93 Contact Map
4l4vA 1 0.864 5 0.93 Contact Map
1j0wA 1 0.424 4.8 0.931 Contact Map
1uvjA 1 0.44 3.7 0.934 Contact Map
1s7qA 1 0.856 3.4 0.935 Contact Map
2v76A 1 0.4 3.4 0.936 Contact Map
1s1mA 4 0.496 3.1 0.936 Contact Map
3ff4A 1 0.744 3 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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