GREMLIN Database
DUF4261 - Domain of unknown function (DUF4261)
PFAM: PF14080 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (75)
Sequences: 2902 (2274)
Seq/√Len: 262.5
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_K47_D3.9621.00
11_P62_H2.8691.00
31_N34_S2.6701.00
5_L33_A2.3831.00
13_L36_L2.0961.00
34_S38_E2.0341.00
45_D61_R1.8931.00
32_L49_I1.8531.00
52_P56_E1.7611.00
21_D24_E1.7381.00
15_V25_V1.7151.00
65_S73_V1.5861.00
15_V29_L1.5821.00
3_L7_A1.5651.00
43_I60_V1.5471.00
8_F37_L1.5211.00
53_S56_E1.5101.00
15_V28_F1.4781.00
62_H74_L1.4531.00
20_L24_E1.4201.00
13_L32_L1.4051.00
13_L29_L1.4001.00
64_P72_E1.3981.00
58_W76_I1.3421.00
68_D71_R1.3311.00
10_L40_G1.2831.00
45_D62_H1.2611.00
14_E75_D1.1981.00
20_L25_V1.1951.00
41_P62_H1.1821.00
69_P73_V1.1811.00
12_D17_F1.1311.00
2_T13_L1.0831.00
35_Y51_G1.0691.00
63_E75_D1.0671.00
31_N35_Y1.0651.00
35_Y42_V1.0601.00
2_T33_A1.0221.00
16_H63_E0.9571.00
43_I74_L0.9511.00
49_I60_V0.9431.00
24_E27_E0.9411.00
48_T57_K0.9001.00
31_N52_P0.8991.00
62_H72_E0.8961.00
17_F25_V0.8861.00
28_F56_E0.8751.00
27_E31_N0.8591.00
16_H75_D0.8561.00
39_N44_K0.8561.00
13_L76_I0.8350.99
18_S22_P0.8150.99
65_S69_P0.8070.99
10_L36_L0.8030.99
34_S37_L0.7940.99
72_E75_D0.7930.99
66_L75_D0.7850.99
34_S53_S0.7850.99
12_D71_R0.7850.99
26_A30_Y0.7810.99
64_P70_E0.7810.99
35_Y48_T0.7800.99
5_L10_L0.7780.99
30_Y33_A0.7770.99
32_L76_I0.7720.99
6_A12_D0.7680.99
39_N42_V0.7630.99
7_A12_D0.7480.99
28_F52_P0.7460.99
36_L43_I0.7260.98
23_G27_E0.7240.98
54_E57_K0.7160.98
68_D72_E0.7000.98
30_Y34_S0.6990.98
21_D64_P0.6970.98
14_E66_L0.6970.98
23_G26_A0.6960.98
27_E34_S0.6950.98
66_L71_R0.6830.98
51_G57_K0.6720.97
1_D12_D0.6420.97
16_H66_L0.6360.96
52_P55_E0.6290.96
15_V18_S0.6140.96
49_I76_I0.6130.96
68_D73_V0.6130.96
3_L6_A0.6060.95
28_F31_N0.6040.95
65_S70_E0.6020.95
51_G54_E0.5980.95
63_E66_L0.5910.95
31_N48_T0.5880.95
41_P45_D0.5840.94
18_S57_K0.5820.94
49_I52_P0.5780.94
39_N72_E0.5760.94
26_A29_L0.5760.94
51_G61_R0.5740.94
63_E73_V0.5620.93
35_Y43_I0.5600.93
8_F12_D0.5520.92
62_H65_S0.5510.92
6_A62_H0.5410.92
17_F21_D0.5400.92
35_Y38_E0.5310.91
3_L11_P0.5300.91
24_E41_P0.5240.90
20_L28_F0.5240.90
48_T63_E0.5200.90
6_A11_P0.5180.90
21_D71_R0.5140.90
15_V20_L0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kmaA 1 0.961 46.3 0.82 Contact Map
3k5jA 1 0.9481 45.6 0.821 Contact Map
4kmdA 2 0.987 38.8 0.828 Contact Map
4km9A 1 0.961 38.5 0.828 Contact Map
4bl9A 1 0.961 25 0.844 Contact Map
1xg4A 4 0.8961 20.2 0.85 Contact Map
3eooA 4 0.8831 13.7 0.861 Contact Map
1zbrA 2 0.9351 8.7 0.873 Contact Map
3lyeA 4 0.9091 7.9 0.876 Contact Map
3vavA 4 0.9091 7.9 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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