GREMLIN Database
DUF4260 - Domain of unknown function (DUF4260)
PFAM: PF14079 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 113 (111)
Sequences: 5712 (4065)
Seq/√Len: 385.8
META: 0.909

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_T107_D4.3441.00
39_S57_A3.4321.00
33_F91_F3.3001.00
11_L60_Y3.0071.00
107_D112_R2.6811.00
24_G80_L2.6281.00
67_A82_G2.3531.00
8_G90_G2.2491.00
15_A87_A2.2471.00
104_G107_D2.1141.00
42_G53_T2.0041.00
12_F91_F1.9601.00
60_Y86_L1.9491.00
52_I102_P1.9371.00
45_A49_V1.7371.00
9_L94_A1.6471.00
70_G78_L1.6441.00
63_P85_W1.6221.00
67_A79_L1.5451.00
29_F87_A1.5281.00
27_W31_L1.5211.00
69_A73_L1.5091.00
60_Y90_G1.4811.00
49_V53_T1.4791.00
8_G60_Y1.4771.00
77_L81_I1.4601.00
16_L29_F1.4251.00
75_S78_L1.4231.00
70_G82_G1.3871.00
15_A83_L1.3761.00
17_A21_Q1.3721.00
2_T5_R1.3691.00
32_L35_A1.3611.00
39_S53_T1.3301.00
40_M57_A1.3291.00
41_L44_L1.2721.00
33_F87_A1.2451.00
11_L86_L1.2411.00
12_F87_A1.2341.00
77_L80_L1.1991.00
25_S28_L1.1811.00
63_P89_I1.1471.00
104_G112_R1.1471.00
15_A86_L1.1351.00
103_T112_R1.1181.00
16_L20_A1.1171.00
106_K112_R1.1031.00
91_F95_L1.0941.00
17_A20_A1.0911.00
56_L62_L1.0591.00
87_A91_F1.0551.00
53_T57_A1.0521.00
46_G49_V1.0501.00
106_K111_G1.0461.00
11_L90_G1.0361.00
62_L85_W0.9911.00
40_M97_Y0.9911.00
6_L10_A0.9671.00
15_A90_G0.9591.00
18_L22_L0.9591.00
43_Y100_K0.9461.00
47_P104_G0.9441.00
52_I56_L0.9361.00
85_W89_I0.9321.00
62_L65_A0.9241.00
26_W30_A0.9241.00
28_L32_L0.8911.00
4_L8_G0.8831.00
63_P86_L0.8791.00
10_A64_L0.8671.00
70_G79_L0.8641.00
5_R8_G0.8561.00
41_L45_A0.8551.00
60_Y89_I0.8541.00
59_T89_I0.8531.00
10_A61_A0.8491.00
63_P82_G0.8451.00
31_L35_A0.8451.00
32_L81_I0.8401.00
6_L61_A0.8401.00
8_G11_L0.8301.00
48_R52_I0.8241.00
32_L84_I0.8121.00
19_Y84_I0.8111.00
91_F94_A0.8041.00
80_L84_I0.7741.00
76_P79_L0.7691.00
27_W30_A0.7601.00
40_M105_F0.7581.00
20_A23_G0.7581.00
28_L31_L0.7561.00
35_A38_L0.7551.00
32_L80_L0.7531.00
4_L101_Y0.7481.00
66_L85_W0.7361.00
12_F16_L0.7141.00
67_A71_L0.7031.00
2_T6_L0.7021.00
66_L78_L0.6940.99
89_I94_A0.6920.99
11_L15_A0.6910.99
43_Y51_A0.6870.99
57_A85_W0.6830.99
60_Y85_W0.6800.99
40_M44_L0.6770.99
22_L83_L0.6740.99
68_A72_L0.6740.99
82_G86_L0.6690.99
13_A20_A0.6650.99
40_M53_T0.6640.99
19_Y32_L0.6580.99
104_G111_G0.6550.99
59_T63_P0.6510.99
18_L21_Q0.6500.99
34_L91_F0.6500.99
62_L89_I0.6440.99
59_T62_L0.6430.99
29_F84_I0.6420.99
62_L86_L0.6390.99
20_A26_W0.6280.99
22_L79_L0.6270.99
14_A18_L0.6240.99
64_L86_L0.6190.99
47_P51_A0.6170.99
19_Y29_F0.6150.99
81_I85_W0.6080.99
35_A81_I0.6070.99
19_Y26_W0.5920.98
47_P103_T0.5890.98
18_L83_L0.5870.98
13_A17_A0.5850.98
101_Y104_G0.5830.98
19_Y23_G0.5650.98
61_A89_I0.5620.98
49_V52_I0.5600.98
38_L57_A0.5600.98
64_L67_A0.5570.98
28_L80_L0.5570.98
65_A69_A0.5560.98
88_H92_D0.5530.97
74_G77_L0.5510.97
6_L9_L0.5480.97
107_D111_G0.5440.97
66_L82_G0.5430.97
101_Y106_K0.5370.97
42_G49_V0.5350.97
48_R102_P0.5300.97
4_L110_L0.5280.97
55_N105_F0.5260.97
73_L76_P0.5250.97
5_R111_G0.5250.97
19_Y24_G0.5200.96
60_Y64_L0.5200.96
46_G50_G0.5190.96
57_A61_A0.5180.96
29_F32_L0.5180.96
16_L33_F0.5150.96
24_G28_L0.5120.96
100_K105_F0.5080.96
47_P111_G0.5080.96
43_Y47_P0.5070.96
16_L23_G0.5060.96
55_N100_K0.5050.96
15_A29_F0.5020.96
38_L41_L0.5010.96
40_M50_G0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhkA 3 0.2212 23.8 0.922 Contact Map
4l69A 2 0.2212 9.8 0.934 Contact Map
3gvaA 1 0.2655 2.7 0.95 Contact Map
4b03D 5 0.3451 2.6 0.95 Contact Map
2gsvA 3 0.1416 2.6 0.95 Contact Map
4dveA 3 0.9735 1.7 0.955 Contact Map
3j27B 2 0.3186 1.3 0.958 Contact Map
4cctD 2 0.3363 1.2 0.959 Contact Map
2wvxA 2 0.5752 1.2 0.959 Contact Map
4cbfB 2 0.3363 1.2 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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