GREMLIN Database
DUF4259 - Domain of unknown function (DUF4259)
PFAM: PF14078 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 133 (125)
Sequences: 2584 (2201)
Seq/√Len: 196.9
META: 0.824

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_G9_E5.5151.00
7_P57_L3.6031.00
12_D54_S3.3721.00
6_G9_E3.3561.00
12_D51_P3.2331.00
57_L107_L2.5741.00
37_D102_L2.3801.00
31_L35_A2.2731.00
56_A106_A2.2321.00
87_W91_H2.1671.00
16_W20_L2.0911.00
116_E120_L2.0061.00
7_P61_E1.9261.00
38_A52_E1.7741.00
124_S127_L1.7031.00
127_L131_R1.6661.00
118_R131_R1.6361.00
2_A54_S1.6091.00
64_A68_G1.5961.00
33_E102_L1.5661.00
1_G11_D1.5401.00
67_L100_V1.5341.00
11_D15_D1.4761.00
104_R108_D1.4641.00
118_R122_E1.4601.00
18_A21_E1.3931.00
36_L102_L1.3911.00
114_D118_R1.3791.00
65_A71_G1.3481.00
122_E131_R1.3371.00
12_D55_E1.3231.00
12_D49_E1.2861.00
23_A31_L1.2741.00
117_L130_W1.2691.00
63_V100_V1.2531.00
100_V104_R1.2521.00
33_E99_L1.2451.00
120_L123_E1.2271.00
61_E68_G1.2141.00
111_L131_R1.2051.00
33_E37_D1.1821.00
70_P73_R1.1751.00
53_A115_S1.1751.00
59_A103_A1.1711.00
126_D129_E1.1641.00
51_P54_S1.1601.00
29_L33_E1.1591.00
48_L53_A1.1391.00
84_V87_W1.1281.00
16_W62_V1.1121.00
48_L109_R1.1051.00
53_A110_V1.1021.00
10_N50_A1.0961.00
16_W35_A1.0931.00
62_V84_V1.0901.00
122_E127_L1.0831.00
39_V48_L1.0801.00
14_L18_A1.0801.00
36_L60_A1.0791.00
32_V36_L1.0781.00
47_Y119_E1.0721.00
29_L66_L1.0641.00
13_A58_A1.0461.00
65_A70_P1.0311.00
19_E55_E1.0201.00
61_E64_A1.0051.00
21_E83_E0.9921.00
32_V35_A0.9911.00
16_W59_A0.9831.00
60_A103_A0.9800.99
95_P99_L0.9780.99
61_E69_G0.9720.99
35_A55_E0.9610.99
20_L87_W0.9580.99
35_A39_V0.9570.99
10_N13_A0.9520.99
47_Y116_E0.9500.99
8_F81_P0.9490.99
24_G29_L0.9440.99
113_E118_R0.9440.99
60_A107_L0.9290.99
20_L24_G0.9260.99
52_E55_E0.9180.99
39_V110_V0.9020.99
36_L103_A0.9000.99
24_G28_D0.8850.99
91_H95_P0.8780.99
1_G15_D0.8650.99
19_E31_L0.8640.99
5_T129_E0.8270.98
10_N57_L0.8170.98
118_R127_L0.8140.98
9_E14_L0.8120.98
65_A80_L0.8070.98
80_L84_V0.8010.98
29_L32_V0.8010.98
21_E84_V0.8000.98
112_G118_R0.7950.98
61_E71_G0.7940.98
20_L62_V0.7740.97
14_L17_L0.7630.97
128_E131_R0.7610.97
56_A103_A0.7600.97
49_E52_E0.7590.97
33_E98_E0.7540.97
17_L21_E0.7470.97
36_L106_A0.7430.97
7_P58_A0.7340.96
104_R111_L0.7340.96
17_L84_V0.7270.96
39_V56_A0.7190.96
60_A110_V0.7150.96
56_A60_A0.7070.95
81_P85_D0.7000.95
17_L83_E0.6970.95
115_S118_R0.6950.95
35_A59_A0.6930.95
36_L63_V0.6920.95
50_A117_L0.6900.95
71_G79_D0.6860.95
23_A28_D0.6850.95
50_A120_L0.6640.94
50_A54_S0.6640.94
18_A22_E0.6590.93
65_A85_D0.6560.93
8_F61_E0.6540.93
97_P100_V0.6530.93
59_A64_A0.6490.93
60_A63_V0.6430.93
47_Y51_P0.6420.93
110_V118_R0.6380.92
7_P10_N0.6320.92
14_L80_L0.6300.92
14_L83_E0.6300.92
101_A105_R0.6300.92
10_N58_A0.6280.92
24_G31_L0.6230.91
53_A117_L0.6200.91
16_W61_E0.6180.91
36_L40_L0.6160.91
67_L104_R0.6050.90
19_E23_A0.6040.90
16_W54_S0.6000.90
65_A81_P0.5980.90
129_E132_A0.5940.89
48_L116_E0.5920.89
49_E54_S0.5880.89
47_Y123_E0.5870.89
58_A63_V0.5870.89
35_A56_A0.5840.89
50_A55_E0.5840.89
10_N54_S0.5810.88
5_T9_E0.5780.88
110_V115_S0.5770.88
50_A116_E0.5740.88
11_D14_L0.5740.88
70_P89_A0.5720.88
15_D18_A0.5700.87
102_L105_R0.5680.87
50_A53_A0.5670.87
86_E90_A0.5630.87
63_V103_A0.5600.86
69_G88_V0.5590.86
94_L97_P0.5550.86
61_E70_P0.5520.86
64_A103_A0.5400.84
66_L99_L0.5390.84
66_L93_A0.5350.84
123_E127_L0.5340.84
51_P120_L0.5330.84
97_P101_A0.5320.84
97_P129_E0.5280.83
68_G71_G0.5240.83
61_E73_R0.5200.82
47_Y52_E0.5200.82
63_V107_L0.5180.82
117_L121_W0.5180.82
91_H96_S0.5170.82
16_W103_A0.5170.82
5_T124_S0.5150.82
30_S33_E0.5140.81
38_A55_E0.5110.81
57_L110_V0.5110.81
12_D50_A0.5100.81
81_P88_V0.5080.81
120_L124_S0.5050.80
38_A86_E0.5050.80
16_W58_A0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sl1A 5 0.4887 6.3 0.913 Contact Map
4l2hA 1 0.594 4.6 0.919 Contact Map
4iu0A 3 0.4812 4.5 0.919 Contact Map
4b3nA 1 0.8947 4.3 0.92 Contact Map
4a0dA 1 0.6842 3.5 0.923 Contact Map
3uekA 1 0.6767 3.2 0.925 Contact Map
3sigA 1 0.406 3 0.926 Contact Map
3u64A 5 0.391 2.5 0.929 Contact Map
3zn6A 1 0.1429 2.3 0.93 Contact Map
2zyoA 1 0.8271 2.1 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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