GREMLIN Database
SpoVIF - Stage VI sporulation protein F
PFAM: PF14069 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 72 (72)
Sequences: 911 (575)
Seq/√Len: 67.7
META: 0.64

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_K53_E4.1111.00
26_D29_D3.0941.00
58_K62_N2.7731.00
50_K54_D2.7531.00
34_R53_E2.4771.00
32_T35_E2.4291.00
50_K53_E2.3411.00
30_E34_R2.1611.00
4_V8_T2.0651.00
34_R54_D2.0351.00
33_L57_V1.6070.99
22_V36_L1.5890.99
29_D32_T1.5470.99
18_L40_V1.5310.99
33_L61_I1.3580.98
17_K20_N1.3030.97
13_E17_K1.2810.97
20_N23_Q1.2610.96
27_L33_L1.2400.96
25_A32_T1.2330.96
56_I60_I1.2140.95
54_D58_K1.2110.95
33_L37_I1.1860.95
18_L43_M1.1820.95
5_E11_N1.1750.94
14_D41_S1.1240.93
35_E38_K1.1070.92
34_R50_K1.1010.92
38_K42_K1.1000.92
19_A22_V1.0940.92
21_G39_Q1.0740.91
4_V15_I1.0660.91
23_Q46_K1.0210.89
37_I56_I1.0180.89
28_K31_A1.0180.89
2_K6_K1.0030.88
5_E8_T0.9980.88
34_R38_K0.9710.86
14_D44_A0.9650.86
1_F13_E0.9630.86
14_D18_L0.9580.86
48_V59_A0.9390.84
12_K65_V0.9350.84
68_N72_L0.9340.84
34_R57_V0.9220.83
25_A36_L0.9080.82
37_I40_V0.9020.82
31_A42_K0.8850.81
15_I40_V0.8740.80
5_E12_K0.8530.78
20_N24_K0.8400.77
2_K5_E0.8250.76
31_A49_S0.8200.75
34_R47_P0.8170.75
3_K6_K0.7860.72
7_K12_K0.7820.72
32_T60_I0.7780.72
47_P58_K0.7740.71
4_V72_L0.7570.69
11_N14_D0.7510.69
7_K68_N0.7470.68
31_A35_E0.7320.67
37_I48_V0.7280.66
64_K67_N0.7200.66
10_V34_R0.7130.65
19_A26_D0.7020.64
12_K15_I0.6980.63
32_T36_L0.6940.63
27_L36_L0.6840.62
5_E9_N0.6750.61
19_A51_E0.6690.60
2_K11_N0.6540.58
52_K59_A0.6500.58
27_L59_A0.6470.57
18_L37_I0.6400.57
18_L45_G0.6200.54
16_K23_Q0.6160.54
42_K72_L0.6130.53
21_G32_T0.6120.53
30_E57_V0.6100.53
21_G45_G0.6090.53
59_A65_V0.6070.53
1_F5_E0.6060.53
12_K66_P0.6010.52
49_S66_P0.6000.52
29_D71_K0.5990.52
16_K46_K0.5990.52
45_G51_E0.5840.50
8_T49_S0.5820.50
12_K16_K0.5790.49
15_I42_K0.5730.49
38_K47_P0.5720.48
13_E46_K0.5710.48
40_V56_I0.5660.48
69_L72_L0.5660.48
25_A33_L0.5620.47
2_K55_K0.5570.47
67_N71_K0.5510.46
45_G54_D0.5480.46
26_D63_D0.5460.45
58_K61_I0.5420.45
3_K27_L0.5380.44
8_T19_A0.5280.43
39_Q52_K0.5240.43
11_N42_K0.5240.43
4_V27_L0.5160.42
5_E22_V0.5070.41
10_V53_E0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ip4B 1 1 27.8 0.859 Contact Map
2zc2A 1 0.5417 26.4 0.861 Contact Map
3al0B 1 1 25.7 0.861 Contact Map
3h0lB 1 1 20.5 0.868 Contact Map
2hz7A 1 0 20.4 0.868 Contact Map
1s4kA 2 0.9583 17.5 0.872 Contact Map
4ut1A 1 0.8889 13.1 0.879 Contact Map
4cr2I 1 0.9167 12.8 0.879 Contact Map
3h5qA 2 0.5972 12.2 0.88 Contact Map
2d6fC 1 0.5972 11.9 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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