GREMLIN Database
LssY_C - LssY C-terminus
PFAM: PF14067 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 188 (181)
Sequences: 5883 (3467)
Seq/√Len: 257.7
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_V81_A4.1381.00
84_K152_D3.6821.00
119_A149_L3.6021.00
27_E31_L3.4321.00
148_Y152_D3.1461.00
43_D63_Y2.7441.00
166_D187_R2.7181.00
141_D144_A2.7081.00
45_L50_S2.6691.00
96_L149_L2.6591.00
9_R13_G2.6321.00
76_R79_D2.5821.00
84_K148_Y2.4911.00
70_P77_P2.4181.00
23_L30_L2.2731.00
26_S29_Q2.2621.00
141_D183_F2.2191.00
146_R185_D2.0161.00
86_R121_R2.0151.00
37_A156_A1.9901.00
176_N180_D1.9811.00
27_E100_K1.9641.00
94_H145_E1.9151.00
164_Y187_R1.8681.00
126_G137_K1.8201.00
42_A83_Q1.8031.00
78_Q81_A1.7711.00
98_F117_G1.7691.00
31_L82_F1.6891.00
10_T13_G1.6851.00
74_F101_T1.6201.00
19_V73_L1.6161.00
95_H136_H1.6071.00
150_V162_V1.5881.00
40_V64_P1.5761.00
120_T138_I1.5541.00
22_V114_V1.5451.00
50_S54_A1.5341.00
23_L98_F1.5161.00
40_V65_T1.5141.00
40_V85_A1.4941.00
31_L41_P1.4931.00
173_E181_P1.4911.00
33_A156_A1.4411.00
34_F149_L1.4281.00
51_L55_R1.4241.00
11_A72_Y1.3961.00
174_G182_Y1.3821.00
55_R59_L1.3761.00
46_T50_S1.3741.00
79_D100_K1.3741.00
151_A155_A1.3681.00
36_A158_L1.3641.00
171_P174_G1.3421.00
151_A154_L1.3381.00
167_G172_L1.3091.00
31_L80_L1.2951.00
29_Q112_R1.2891.00
60_G91_R1.2871.00
25_G30_L1.2821.00
28_E32_A1.2771.00
21_L149_L1.2741.00
23_L117_G1.2441.00
47_L50_S1.2321.00
95_H122_D1.2311.00
137_K180_D1.2281.00
45_L49_S1.2231.00
173_E183_F1.2021.00
56_A90_P1.1941.00
30_L98_F1.1761.00
52_R56_A1.1641.00
147_D151_A1.1621.00
31_L35_A1.1511.00
34_F96_L1.1411.00
102_P110_D1.1331.00
30_L80_L1.1271.00
41_P83_Q1.1261.00
60_G89_S1.1201.00
122_D136_H1.1101.00
100_K113_P1.0991.00
128_S131_T1.0871.00
123_I137_K1.0831.00
71_L135_T1.0801.00
86_R92_K1.0681.00
47_L51_L1.0531.00
16_G71_L1.0411.00
175_R181_P1.0391.00
139_D144_A1.0371.00
9_R12_D1.0271.00
26_S113_P1.0141.00
28_E31_L1.0051.00
96_L117_G1.0051.00
93_R122_D0.9991.00
57_F90_P0.9891.00
154_L159_V0.9741.00
153_L159_V0.9681.00
96_L119_A0.9581.00
45_L70_P0.9501.00
80_L98_F0.9491.00
172_L187_R0.9381.00
147_D164_Y0.9371.00
46_T49_S0.9371.00
21_L96_L0.9281.00
9_R14_I0.9251.00
174_G183_F0.9191.00
17_D20_N0.9101.00
122_D138_I0.9021.00
154_L162_V0.9011.00
117_G149_L0.8921.00
123_I139_D0.8821.00
97_R136_H0.8791.00
73_L116_V0.8791.00
170_P174_G0.8731.00
53_I90_P0.8721.00
94_H121_R0.8611.00
99_W118_A0.8591.00
169_G182_Y0.8560.99
4_L116_V0.8530.99
69_S135_T0.8510.99
105_F114_V0.8450.99
32_A36_A0.8450.99
110_D114_V0.8360.99
120_T142_V0.8340.99
106_E112_R0.8270.99
93_R136_H0.8200.99
119_A148_Y0.7970.99
97_R120_T0.7910.99
101_T116_V0.7760.99
182_Y187_R0.7750.99
43_D65_T0.7710.99
149_L152_D0.7680.99
19_V116_V0.7680.99
29_Q32_A0.7640.99
37_A153_L0.7630.99
49_S53_I0.7570.99
79_D99_W0.7510.99
48_R52_R0.7500.99
152_D155_A0.7480.99
37_A152_D0.7370.98
36_A155_A0.7360.98
100_K104_T0.7350.98
82_F96_L0.7350.98
129_R137_K0.7330.98
25_G115_W0.7320.98
27_E80_L0.7320.98
49_S63_Y0.7300.98
119_A145_E0.7270.98
126_G129_R0.7260.98
22_V116_V0.7240.98
34_F98_F0.7180.98
126_G135_T0.7070.98
171_P176_N0.7060.98
122_D145_E0.7060.98
21_L117_G0.7050.98
24_V114_V0.6990.98
150_V154_L0.6980.98
68_V120_T0.6970.98
94_H119_A0.6910.98
41_P80_L0.6840.98
168_V184_T0.6830.98
126_G180_D0.6810.97
169_G172_L0.6760.97
20_N118_A0.6760.97
154_L161_A0.6750.97
174_G179_G0.6740.97
18_P142_V0.6740.97
41_P65_T0.6720.97
53_I66_A0.6720.97
122_D142_V0.6700.97
17_D71_L0.6690.97
129_R132_G0.6680.97
33_A158_L0.6670.97
51_L54_A0.6670.97
124_G137_K0.6650.97
127_L132_G0.6610.97
140_P181_P0.6590.97
11_A14_I0.6570.97
169_G173_E0.6570.97
94_H148_Y0.6530.97
42_A81_A0.6460.97
177_G180_D0.6440.96
27_E113_P0.6400.96
42_A94_H0.6340.96
168_V171_P0.6310.96
16_G20_N0.6310.96
68_V97_R0.6300.96
102_P114_V0.6260.96
9_R15_P0.6250.96
49_S66_A0.6240.96
45_L53_I0.6240.96
57_F130_R0.6220.96
131_T134_I0.6220.96
93_R146_R0.6190.96
27_E41_P0.6060.95
83_Q136_H0.6060.95
143_D184_T0.6030.95
32_A35_A0.6010.95
17_D95_H0.5970.95
153_L157_G0.5960.95
102_P163_G0.5960.95
180_D183_F0.5960.95
167_G171_P0.5940.95
72_Y78_Q0.5870.94
97_R122_D0.5840.94
68_V78_Q0.5820.94
177_G182_Y0.5780.94
8_T16_G0.5780.94
56_A61_R0.5750.94
142_V182_Y0.5740.93
167_G182_Y0.5730.93
41_P44_P0.5730.93
64_P89_S0.5720.93
59_L91_R0.5710.93
165_V168_V0.5710.93
171_P183_F0.5650.93
69_S95_H0.5640.93
32_A158_L0.5610.93
11_A70_P0.5570.92
154_L163_G0.5570.92
41_P82_F0.5560.92
106_E111_G0.5560.92
52_R63_Y0.5550.92
84_K149_L0.5530.92
64_P85_A0.5520.92
104_T113_P0.5510.92
71_L118_A0.5500.92
56_A63_Y0.5490.92
150_V164_Y0.5490.92
166_D172_L0.5460.92
153_L158_L0.5450.92
91_R125_V0.5450.92
80_L145_E0.5430.91
140_P183_F0.5430.91
169_G187_R0.5410.91
35_A41_P0.5400.91
20_N71_L0.5400.91
168_V187_R0.5370.91
154_L157_G0.5370.91
129_R133_Q0.5370.91
72_Y75_G0.5360.91
155_A158_L0.5340.91
55_R61_R0.5340.91
6_R9_R0.5290.90
18_P99_W0.5280.90
103_F114_V0.5280.90
68_V118_A0.5280.90
24_V112_R0.5240.90
128_S177_G0.5230.90
172_L175_R0.5230.90
175_R178_T0.5220.90
73_L78_Q0.5220.90
52_R55_R0.5200.90
143_D146_R0.5190.90
103_F160_A0.5190.90
92_K121_R0.5180.89
4_L150_V0.5160.89
54_A58_L0.5160.89
158_L162_V0.5150.89
8_T11_A0.5140.89
57_F91_R0.5120.89
25_G28_E0.5120.89
74_F114_V0.5110.89
168_V183_F0.5110.89
171_P182_Y0.5100.89
129_R134_I0.5080.89
8_T87_G0.5060.88
127_L130_R0.5060.88
71_L146_R0.5030.88
26_S112_R0.5020.88
56_A88_N0.5020.88
104_T111_G0.5000.88
142_V168_V0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nzjA 1 0.3032 8.8 0.949 Contact Map
3go9A 1 0.1915 4 0.956 Contact Map
3kvhA 2 0.3404 3.8 0.957 Contact Map
1jr2A 1 0.2819 3.2 0.959 Contact Map
2czvC 2 0.1915 3.2 0.959 Contact Map
3pfgA 2 0.3138 3.2 0.959 Contact Map
4gekA 2 0.3351 3.1 0.959 Contact Map
3eyiA 1 0.266 2.9 0.959 Contact Map
2a3zC 1 0.0904 2.9 0.959 Contact Map
2uyoA 1 0.3617 2.7 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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