GREMLIN Database
DUF4253 - Domain of unknown function (DUF4253)
PFAM: PF14062 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 109 (107)
Sequences: 3148 (2455)
Seq/√Len: 237.4
META: 0.859

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_H79_F4.0631.00
36_L57_L3.0981.00
77_Y85_D2.8211.00
9_D12_D2.7011.00
15_A33_I2.5881.00
65_D68_E2.5661.00
38_S42_R2.5621.00
44_G60_A2.1851.00
76_H83_I2.0351.00
20_G23_W2.0121.00
14_P36_L1.9591.00
90_T93_A1.9021.00
11_W40_E1.8021.00
76_H106_F1.7761.00
39_W75_E1.7581.00
42_R75_E1.7321.00
69_A99_L1.6371.00
70_L95_A1.6271.00
38_S75_E1.5881.00
10_P40_E1.5841.00
51_G54_T1.5751.00
49_G56_E1.5151.00
10_P47_L1.5151.00
28_D31_E1.4791.00
5_V13_V1.4731.00
46_E60_A1.3991.00
37_R41_E1.3921.00
21_G27_P1.3341.00
21_G24_N1.3321.00
14_P50_I1.3021.00
82_D86_Q1.2971.00
76_H98_L1.2921.00
72_L76_H1.2841.00
81_P85_D1.2551.00
49_G54_T1.2381.00
76_H94_L1.1931.00
72_L98_L1.1831.00
39_W76_H1.1761.00
36_L55_L1.1341.00
11_W37_R1.1121.00
35_V75_E1.0991.00
77_Y84_V1.0691.00
89_G93_A1.0571.00
56_E105_Y1.0531.00
23_W27_P1.0461.00
45_A57_L1.0411.00
7_T13_V1.0391.00
7_T16_A1.0261.00
82_D107_W1.0251.00
8_A12_D1.0151.00
56_E103_V0.9991.00
59_V104_W0.9921.00
62_P102_R0.9911.00
66_R70_L0.9881.00
38_S41_E0.9771.00
23_W26_C0.9741.00
3_A17_L0.9551.00
25_Y81_P0.9461.00
35_V39_W0.9461.00
39_W43_Y0.9431.00
20_G27_P0.9381.00
66_R99_L0.9381.00
46_E58_R0.9371.00
79_F106_F0.9151.00
88_T97_E0.9131.00
45_A104_W0.8790.99
38_S43_Y0.8680.99
27_P31_E0.8660.99
84_V94_L0.8650.99
29_P33_I0.8520.99
40_E46_E0.8500.99
53_D107_W0.8490.99
97_E100_G0.8470.99
19_W50_I0.8440.99
40_E45_A0.8370.99
59_V62_P0.8350.99
29_P32_H0.8340.99
10_P46_E0.8340.99
24_N82_D0.8330.99
92_E96_A0.8270.99
15_A30_E0.8210.99
37_R40_E0.8200.99
69_A73_A0.8180.99
20_G26_C0.8150.99
84_V88_T0.8130.99
44_G61_R0.8070.99
83_I87_G0.8040.99
42_R68_E0.8010.99
43_Y72_L0.7920.99
54_T105_Y0.7900.99
24_N109_D0.7860.99
33_I40_E0.7850.99
35_V38_S0.7820.99
40_E44_G0.7810.99
35_V79_F0.7750.99
9_D40_E0.7600.98
91_L95_A0.7570.98
3_A6_P0.7510.98
70_L92_E0.7510.98
74_A91_L0.7320.98
83_I88_T0.7300.98
84_V87_G0.7260.98
50_I55_L0.7120.98
73_A95_A0.7050.97
33_I47_L0.7010.97
68_E71_A0.6990.97
97_E101_S0.6840.97
59_V63_P0.6840.97
36_L45_A0.6760.97
63_P72_L0.6740.97
86_Q107_W0.6710.96
6_P16_A0.6710.96
27_P32_H0.6690.96
43_Y63_P0.6620.96
39_W57_L0.6610.96
48_V58_R0.6490.96
30_E33_I0.6490.96
12_D15_A0.6450.96
31_E35_V0.6430.96
64_T100_G0.6390.95
77_Y86_Q0.6380.95
34_A37_R0.6320.95
65_D69_A0.6310.95
62_P69_A0.6290.95
47_L50_I0.6270.95
83_I94_L0.6260.95
36_L47_L0.6240.95
93_A97_E0.6190.94
33_I37_R0.6170.94
42_R71_A0.6040.94
26_C31_E0.6040.94
7_T12_D0.6000.94
84_V93_A0.5990.93
63_P66_R0.5970.93
57_L104_W0.5970.93
45_A59_V0.5920.93
24_N52_F0.5810.92
10_P13_V0.5780.92
39_W72_L0.5760.92
19_W26_C0.5750.92
35_V106_F0.5710.92
66_R72_L0.5640.91
64_T68_E0.5580.91
102_R105_Y0.5560.91
12_D38_S0.5510.90
87_G94_L0.5470.90
10_P106_F0.5440.90
73_A94_L0.5420.90
43_Y75_E0.5240.88
70_L74_A0.5220.88
43_Y60_A0.5160.87
84_V91_L0.5100.87
5_V17_L0.5090.87
96_A99_L0.5090.87
99_L102_R0.5080.86
47_L55_L0.5050.86
100_G103_V0.5050.86
14_P33_I0.5050.86
39_W44_G0.5030.86
67_E70_L0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vz9B 1 0.7798 23.4 0.893 Contact Map
1gqiA 2 0.945 9 0.911 Contact Map
1l8nA 2 0.9358 8.3 0.912 Contact Map
4qclA 1 0.9817 7.8 0.914 Contact Map
1dgsA 1 0.9633 7.3 0.915 Contact Map
1w7pD 1 0.8807 7.1 0.915 Contact Map
3iayA 1 0.9725 6.9 0.916 Contact Map
3a4uB 1 0.5688 6.9 0.916 Contact Map
3sgiA 1 0.1284 5.7 0.919 Contact Map
2d1pA 2 0.9083 5.6 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0057 seconds.