GREMLIN Database
DUF4252 - Domain of unknown function (DUF4252)
PFAM: PF14060 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 157 (151)
Sequences: 10362 (8147)
Seq/√Len: 663.0
META: 0.923

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_D151_K3.9221.00
78_S139_V3.2881.00
19_Q22_Q3.2031.00
114_V132_V2.8981.00
12_L15_P2.7171.00
85_S88_D2.5941.00
66_E151_K2.5701.00
46_G72_K2.4061.00
103_E106_R2.4001.00
108_K113_N2.2411.00
70_G151_K2.2181.00
64_A68_L2.2161.00
124_K146_D2.1311.00
103_E115_K2.1271.00
9_L12_L2.0331.00
29_L33_Y1.9151.00
84_Y87_A1.9151.00
116_I130_V1.8561.00
132_V139_V1.7591.00
47_S102_E1.7451.00
121_E126_K1.7381.00
118_V125_I1.7381.00
70_G146_D1.6901.00
119_K126_K1.6801.00
10_L13_S1.6731.00
85_S89_Y1.6271.00
103_E117_Y1.6041.00
14_L17_F1.6011.00
40_T78_S1.5721.00
107_V114_V1.5711.00
81_D136_D1.5601.00
20_S23_K1.5251.00
84_Y88_D1.5181.00
24_L27_D1.4831.00
27_D31_D1.4581.00
81_D85_S1.4471.00
89_Y133_A1.4361.00
30_F33_Y1.4281.00
74_I143_I1.3951.00
127_E144_V1.3881.00
105_M116_I1.3571.00
120_E123_D1.3411.00
63_E154_K1.3191.00
106_R115_K1.2991.00
116_I128_L1.2711.00
66_E69_K1.2581.00
8_L11_L1.2431.00
151_K154_K1.2371.00
11_L14_L1.2361.00
39_V77_L1.2341.00
19_Q23_K1.2291.00
127_E142_N1.2021.00
76_V141_V1.1411.00
33_Y91_E1.1341.00
41_S106_R1.1291.00
64_A67_L1.1251.00
63_E66_E1.1101.00
75_R142_N1.1041.00
41_S77_L1.1041.00
47_S50_K1.1031.00
6_L10_L1.0951.00
47_S120_E1.0931.00
84_Y89_Y1.0871.00
58_D61_D1.0841.00
65_K69_K1.0831.00
133_A138_F1.0781.00
90_K93_R1.0761.00
90_K94_K1.0721.00
9_L13_S1.0671.00
4_L7_L1.0571.00
134_G137_E1.0551.00
46_G50_K1.0521.00
41_S75_R1.0421.00
102_E120_E1.0391.00
121_E124_K1.0301.00
53_A56_D1.0281.00
89_Y93_R1.0221.00
97_K100_G1.0161.00
150_E153_S1.0151.00
15_P18_A1.0121.00
92_V95_Q1.0081.00
28_K31_D0.9991.00
7_L10_L0.9941.00
78_S132_V0.9911.00
10_L14_L0.9851.00
95_Q99_P0.9801.00
86_K90_K0.9671.00
81_D89_Y0.9661.00
101_Y127_E0.9471.00
49_L52_A0.9461.00
45_S48_M0.9451.00
13_S17_F0.9411.00
88_D92_V0.9341.00
32_K91_E0.9271.00
11_L15_P0.9251.00
20_S24_L0.9191.00
126_K146_D0.9121.00
25_S28_K0.8881.00
24_L28_K0.8851.00
73_G144_V0.8791.00
96_L129_L0.8691.00
8_L12_L0.8631.00
91_E95_Q0.8541.00
22_Q25_S0.8541.00
45_S102_E0.8521.00
72_K144_V0.8461.00
130_V141_V0.8461.00
81_D84_Y0.8451.00
86_K89_Y0.8421.00
17_F20_S0.8371.00
112_E134_G0.8361.00
16_A19_Q0.8341.00
93_R115_K0.8321.00
149_L153_S0.8301.00
26_L29_L0.8271.00
29_L32_K0.8221.00
116_I141_V0.8131.00
54_K150_E0.8121.00
100_G119_K0.8091.00
104_L118_V0.8051.00
108_K115_K0.7991.00
80_E112_E0.7891.00
27_D30_F0.7831.00
87_A91_E0.7801.00
57_D62_D0.7671.00
92_V96_L0.7651.00
82_G85_S0.7601.00
101_Y142_N0.7571.00
147_I151_K0.7461.00
62_D66_E0.7431.00
42_V76_V0.7381.00
112_E137_E0.7371.00
49_L71_L0.7361.00
70_G147_I0.7351.00
81_D86_K0.7261.00
36_A39_V0.7211.00
93_R97_K0.7151.00
128_L143_I0.7141.00
50_K53_A0.7131.00
52_A55_F0.7091.00
52_A56_D0.7061.00
39_V84_Y0.7031.00
29_L138_F0.7021.00
83_E87_A0.7001.00
107_V132_V0.6961.00
24_L32_K0.6931.00
129_L142_N0.6891.00
95_Q100_G0.6841.00
27_D140_L0.6801.00
95_Q98_S0.6781.00
94_K97_K0.6721.00
88_D91_E0.6711.00
23_K28_K0.6691.00
107_V139_V0.6661.00
73_G79_F0.6641.00
15_P19_Q0.6571.00
26_L30_F0.6571.00
125_I128_L0.6561.00
96_L99_P0.6541.00
23_K27_D0.6531.00
103_E107_V0.6481.00
97_K103_E0.6481.00
13_S19_Q0.6451.00
70_G148_D0.6421.00
74_I141_V0.6361.00
4_L12_L0.6321.00
148_D153_S0.6271.00
97_K117_Y0.6271.00
4_L10_L0.6231.00
56_D59_E0.6201.00
88_D138_F0.6051.00
147_I153_S0.6041.00
13_S16_A0.6021.00
39_V79_F0.6021.00
149_L152_L0.6021.00
6_L9_L0.5921.00
106_R113_N0.5891.00
33_Y39_V0.5881.00
81_D88_D0.5871.00
79_F85_S0.5851.00
62_D65_K0.5821.00
42_V107_V0.5811.00
43_T77_L0.5791.00
59_E62_D0.5781.00
102_E118_V0.5781.00
53_A62_D0.5771.00
36_A79_F0.5771.00
6_L12_L0.5761.00
105_M130_V0.5761.00
30_F77_L0.5751.00
110_K113_N0.5741.00
35_D40_T0.5681.00
22_Q28_K0.5681.00
33_Y77_L0.5661.00
93_R98_S0.5611.00
58_D65_K0.5581.00
83_E88_D0.5571.00
43_T73_G0.5551.00
64_A69_K0.5551.00
45_S52_A0.5481.00
33_Y36_A0.5481.00
91_E94_K0.5471.00
6_L11_L0.5471.00
37_D110_K0.5441.00
119_K122_G0.5441.00
35_D108_K0.5371.00
43_T75_R0.5321.00
40_T107_V0.5301.00
42_V78_S0.5280.99
20_S25_S0.5280.99
120_E125_I0.5260.99
56_D65_K0.5240.99
45_S73_G0.5220.99
4_L13_S0.5220.99
128_L153_S0.5210.99
87_A90_K0.5180.99
115_K118_V0.5140.99
71_L143_I0.5130.99
94_K98_S0.5130.99
26_L33_Y0.5100.99
12_L17_F0.5070.99
82_G89_Y0.5060.99
63_E151_K0.5050.99
109_D137_E0.5050.99
9_L15_P0.5050.99
93_R131_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q22A 1 0.7707 20.6 0.887 Contact Map
3razA 1 0.7134 7 0.908 Contact Map
4k3bA 1 0.586 6.8 0.908 Contact Map
2p5qA 3 0.8344 5.8 0.911 Contact Map
2qtfA 1 0.4777 5.3 0.913 Contact Map
2v1mA 1 0.8344 5.2 0.913 Contact Map
2hyxA 2 0.7261 4.9 0.915 Contact Map
3dwvA 1 0.8344 4.8 0.915 Contact Map
2vupA 1 0.8344 4.6 0.916 Contact Map
2cvbA 1 0.7325 4.5 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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