GREMLIN Database
PcfK - PcfK-like protein
PFAM: PF14058 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 140 (134)
Sequences: 1168 (897)
Seq/√Len: 77.5
META: 0.885

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_K15_D3.9391.00
7_K36_D2.8761.00
27_K30_K2.8531.00
15_D28_Y2.5921.00
30_K73_D2.5611.00
45_E65_W2.5481.00
45_E48_K2.4311.00
57_F65_W2.3391.00
27_K71_D2.3121.00
68_H72_E2.2451.00
100_E104_K2.1611.00
34_N37_D2.0921.00
16_E19_E2.0811.00
68_H71_D2.0801.00
38_C70_Y2.0501.00
46_V65_W2.0311.00
42_I66_A1.9721.00
11_K28_Y1.9711.00
46_V57_F1.8671.00
17_R67_V1.8571.00
25_A29_A1.8121.00
113_E116_K1.7921.00
72_E75_I1.7681.00
57_F62_V1.6001.00
16_E20_E1.5901.00
38_C66_A1.5871.00
58_T62_V1.5580.99
34_N69_Y1.5530.99
67_V71_D1.4920.99
17_R20_E1.4770.99
64_G68_H1.4700.99
76_E79_K1.4580.99
37_D40_T1.4150.99
38_C42_I1.3510.98
113_E117_L1.3100.98
40_T44_N1.2870.98
24_F28_Y1.2860.98
114_L118_K1.2790.98
26_E29_A1.2620.98
6_F56_G1.2450.97
85_V88_N1.2370.97
61_E65_W1.2330.97
27_K73_D1.2260.97
52_S55_N1.2220.97
44_N78_G1.2140.97
95_E98_K1.2100.97
103_K107_K1.2020.97
52_S57_F1.1890.96
22_E26_E1.1840.96
58_T61_E1.1790.96
35_I70_Y1.1710.96
12_E16_E1.1620.96
33_K69_Y1.1590.96
17_R71_D1.1280.95
101_A105_A1.1270.95
40_T78_G1.1160.95
46_V52_S1.1050.95
13_Y17_R1.1010.94
104_K108_K1.1010.94
8_E11_K1.0950.94
12_E15_D1.0860.94
119_K122_K1.0750.94
33_K38_C1.0680.94
94_T97_E1.0680.94
114_L117_L1.0610.93
107_K111_E1.0580.93
106_I109_Y1.0550.93
7_K39_I1.0390.93
32_N73_D1.0370.93
93_L97_E1.0320.92
56_G88_N1.0320.92
54_C57_F1.0220.92
37_D44_N1.0210.92
109_Y114_L1.0080.91
8_E12_E0.9870.91
111_E114_L0.9850.90
5_N8_E0.9810.90
112_E117_L0.9810.90
115_A118_K0.9740.90
109_Y113_E0.9720.90
122_K125_K0.9640.90
32_N74_D0.9480.89
2_T5_N0.9440.89
106_I113_E0.9380.88
45_E68_H0.9370.88
109_Y118_K0.9340.88
131_E135_L0.9330.88
102_R110_Q0.9010.86
9_T63_Y0.9000.86
59_D63_Y0.8990.86
94_T105_A0.8840.85
112_E116_K0.8840.85
17_R23_L0.8810.85
4_E8_E0.8790.85
133_G136_S0.8740.84
95_E99_A0.8690.84
4_E7_K0.8640.84
23_L27_K0.8610.83
110_Q114_L0.8610.83
110_Q120_K0.8600.83
100_E105_A0.8440.82
101_A106_I0.8360.82
37_D77_V0.8340.81
113_E118_K0.8300.81
37_D78_G0.8120.80
101_A104_K0.7870.78
105_A112_E0.7650.76
40_T77_V0.7630.75
84_K87_V0.7530.74
71_D75_I0.7510.74
111_E115_A0.7510.74
112_E115_A0.7430.73
106_I117_L0.7310.72
64_G71_D0.7270.72
27_K67_V0.7230.71
129_K132_E0.7220.71
63_Y66_A0.7210.71
93_L105_A0.7180.71
10_I137_L0.7150.71
126_K129_K0.7090.70
18_A28_Y0.6990.69
127_K135_L0.6990.69
58_T65_W0.6990.69
93_L101_A0.6970.69
100_E103_K0.6960.68
81_I84_K0.6960.68
40_T53_G0.6950.68
127_K130_E0.6930.68
118_K121_K0.6890.68
132_E135_L0.6880.68
110_Q117_L0.6780.66
24_F38_C0.6760.66
95_E105_A0.6690.65
115_A119_K0.6610.64
64_G72_E0.6560.64
103_K106_I0.6490.63
99_A111_E0.6480.63
104_K107_K0.6430.62
107_K110_Q0.6410.62
110_Q115_A0.6290.61
106_I110_Q0.6280.61
99_A115_A0.6200.60
57_F61_E0.6180.59
38_C69_Y0.6180.59
18_A24_F0.6170.59
109_Y121_K0.6160.59
5_N58_T0.6140.59
91_V95_E0.6120.59
103_K120_K0.6120.59
44_N47_Q0.6100.58
70_Y73_D0.6030.57
46_V62_V0.6000.57
108_K111_E0.5990.57
13_Y67_V0.5980.57
97_E109_Y0.5970.57
32_N37_D0.5950.56
13_Y41_Y0.5950.56
101_A109_Y0.5910.56
47_Q59_D0.5880.56
102_R107_K0.5810.55
108_K114_L0.5790.54
98_K109_Y0.5790.54
3_T6_F0.5760.54
130_E135_L0.5730.54
17_R27_K0.5620.52
126_K133_G0.5550.51
30_K68_H0.5540.51
105_A109_Y0.5510.51
38_C75_I0.5500.51
15_D25_A0.5440.50
117_L121_K0.5420.50
25_A38_C0.5390.49
91_V97_E0.5380.49
46_V86_V0.5370.49
46_V61_E0.5350.49
80_P99_A0.5350.49
6_F39_I0.5340.49
6_F14_L0.5340.49
99_A102_R0.5320.48
84_K130_E0.5320.48
129_K133_G0.5300.48
131_E134_Q0.5280.48
102_R106_I0.5250.48
12_E22_E0.5240.47
106_I118_K0.5230.47
97_E105_A0.5220.47
94_T102_R0.5210.47
80_P83_C0.5210.47
36_D39_I0.5190.47
7_K35_I0.5190.47
30_K34_N0.5170.47
114_L119_K0.5120.46
43_L62_V0.5110.46
27_K32_N0.5100.46
109_Y117_L0.5090.46
5_N12_E0.5040.45
86_V90_T0.5030.45
9_T88_N0.5020.45
93_L100_E0.5010.44
18_A29_A0.5000.44
91_V104_K0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x8qA 1 0.3714 10 0.924 Contact Map
3l9tA 1 0.3643 8.7 0.927 Contact Map
3jxyA 1 0.3929 8.1 0.927 Contact Map
3zljC 2 0 5.6 0.933 Contact Map
4f9kA 2 0.3857 4.6 0.935 Contact Map
2kygA 2 0.3571 4.6 0.935 Contact Map
3al0B 1 0.5 4.3 0.936 Contact Map
2od6A 2 0.3071 3.2 0.94 Contact Map
3h0lB 1 0.1071 3.2 0.94 Contact Map
1v9dA 3 0.6929 3.2 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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