GREMLIN Database
GGGtGRT - GGGtGRT protein
PFAM: PF14057 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 327 (327)
Sequences: 814 (125)
Seq/√Len: 6.9
META: 0.848

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_Y189_Y7.1261.00
234_P280_T4.4800.98
44_I133_G3.9610.96
171_Q185_K3.8610.95
242_E246_N3.7830.94
176_Y203_D3.7800.94
183_I214_H3.3600.89
20_I29_I3.2190.87
119_L236_A3.1150.85
174_F206_R2.9880.83
213_H242_E2.9650.82
114_K144_E2.9560.82
28_K32_D2.9490.82
280_T286_S2.9410.82
213_H246_N2.8690.80
202_A211_I2.8590.80
38_Y53_C2.8530.80
20_I58_L2.7230.76
10_K93_D2.6890.75
18_Y66_K2.6860.75
308_M316_A2.6730.75
36_D39_K2.6560.74
20_I26_A2.6250.73
181_L214_H2.6010.73
234_P286_S2.4170.67
48_A53_C2.4050.66
186_E198_R2.4020.66
44_I93_D2.3940.66
27_K31_L2.3550.65
173_E176_Y2.3400.64
136_R193_E2.3150.63
236_A250_Y2.2550.61
173_E203_D2.2550.61
74_A78_I2.1750.58
264_H267_N2.1170.56
277_M280_T2.0780.55
3_G51_N2.0730.54
188_A195_A2.0480.53
58_L84_A2.0330.53
119_L250_Y1.8780.47
133_G136_R1.8670.47
206_R242_E1.8060.44
225_S264_H1.7710.43
117_A199_C1.7170.41
4_Y8_I1.7050.40
183_I186_E1.6860.40
305_L313_M1.6830.40
105_A317_T1.6760.39
206_R213_H1.6760.39
176_Y206_R1.6610.39
234_P277_M1.6530.39
9_D12_N1.6410.38
17_E80_E1.6050.37
76_E110_R1.5840.36
259_T264_H1.5830.36
281_M284_M1.5820.36
38_Y50_E1.5730.36
225_S252_S1.5690.36
68_C77_A1.5630.35
10_K80_E1.5520.35
267_N285_H1.5430.35
29_I64_I1.5400.35
42_K53_C1.5350.34
252_S285_H1.5330.34
229_T277_M1.5220.34
20_I64_I1.5200.34
252_S264_H1.5130.34
205_V280_T1.5120.34
222_T253_V1.5120.34
29_I58_L1.5060.33
8_I12_N1.5050.33
21_A25_E1.4940.33
25_E29_I1.4900.33
71_A74_A1.4820.33
220_S236_A1.4800.33
183_I198_R1.4460.31
282_G285_H1.4380.31
228_P267_N1.4280.31
51_N305_L1.4190.31
282_G289_Q1.3920.30
173_E182_K1.3790.29
14_V62_I1.3720.29
94_D179_G1.3690.29
243_C246_N1.3630.29
87_I301_E1.3500.28
35_I60_A1.3440.28
206_R234_P1.3400.28
3_G10_K1.3370.28
147_R188_A1.3310.28
68_C117_A1.3240.28
259_T282_G1.3140.27
252_S259_T1.3110.27
60_A320_V1.3040.27
225_S267_N1.3030.27
37_V53_C1.3010.27
173_E234_P1.2860.26
114_K180_E1.2700.26
119_L212_M1.2660.26
259_T267_N1.2590.26
216_G248_K1.2420.25
222_T225_S1.2320.25
31_L38_Y1.2300.25
259_T289_Q1.2290.25
2_E6_R1.1990.24
225_S228_P1.1980.24
222_T259_T1.1610.23
222_T252_S1.1570.23
229_T268_M1.1510.23
253_V259_T1.1490.23
203_D234_P1.1480.23
228_P285_H1.1480.23
66_K77_A1.1430.22
264_H282_G1.1320.22
252_S267_N1.1160.22
72_A110_R1.1140.22
314_V318_V1.1140.22
76_E80_E1.1130.22
189_Y206_R1.1090.21
51_N117_A1.1060.21
111_E182_K1.1030.21
42_K50_E1.0960.21
220_S250_Y1.0920.21
44_I136_R1.0900.21
189_Y197_V1.0780.21
20_I35_I1.0740.21
225_S259_T1.0660.20
50_E164_I1.0610.20
222_T282_G1.0600.20
105_A203_D1.0590.20
94_D174_F1.0440.20
117_A159_Y1.0430.20
225_S229_T1.0400.20
119_L220_S1.0400.20
228_P252_S1.0390.20
81_G253_V1.0390.20
105_A137_S1.0380.20
285_H289_Q1.0340.20
258_G261_R1.0280.19
37_V44_I1.0280.19
26_A29_I1.0260.19
78_I281_M1.0230.19
264_H285_H1.0190.19
133_G137_S1.0160.19
1_F7_R1.0140.19
234_P242_E1.0140.19
222_T264_H1.0070.19
60_A64_I1.0060.19
113_T218_D1.0040.19
29_I32_D1.0010.19
38_Y42_K0.9970.19
141_V196_K0.9960.19
30_C64_I0.9920.19
68_C74_A0.9890.19
105_A187_K0.9850.18
252_S282_G0.9800.18
31_L35_I0.9680.18
64_I198_R0.9620.18
81_G219_V0.9600.18
315_G322_V0.9590.18
267_N282_G0.9550.18
39_K43_G0.9540.18
147_R200_Y0.9540.18
318_V322_V0.9440.18
87_I117_A0.9430.18
225_S282_G0.9420.18
38_Y199_C0.9390.17
13_A16_K0.9360.17
54_W97_V0.9340.17
225_S253_V0.9330.17
37_V57_T0.9200.17
94_D206_R0.9170.17
11_I20_I0.9150.17
41_V57_T0.9100.17
305_L317_T0.9080.17
188_A196_K0.9070.17
147_R216_G0.9060.17
132_I162_S0.9010.17
1_F11_I0.8960.17
15_L23_L0.8920.16
107_M249_K0.8900.16
10_K17_E0.8880.16
132_I165_N0.8860.16
204_D225_S0.8850.16
176_Y234_P0.8850.16
204_D252_S0.8800.16
64_I238_T0.8790.16
144_E219_V0.8710.16
70_K73_E0.8710.16
162_S203_D0.8660.16
106_A110_R0.8630.16
137_S194_R0.8600.16
222_T228_P0.8590.16
38_Y48_A0.8590.16
174_F183_I0.8570.16
319_A323_A0.8570.16
205_V222_T0.8550.16
14_V78_I0.8530.16
253_V264_H0.8520.16
315_G318_V0.8520.16
204_D250_Y0.8510.16
37_V174_F0.8500.16
31_L117_A0.8500.16
228_P264_H0.8490.16
10_K78_I0.8490.16
216_G243_C0.8420.15
225_S285_H0.8410.15
32_D60_A0.8410.15
16_K35_I0.8400.15
253_V282_G0.8400.15
31_L53_C0.8390.15
68_C73_E0.8380.15
25_E180_E0.8350.15
27_K38_Y0.8310.15
188_A211_I0.8300.15
219_V243_C0.8300.15
259_T269_A0.8290.15
264_H280_T0.8290.15
222_T267_N0.8280.15
277_M286_S0.8270.15
305_L320_V0.8260.15
171_Q187_K0.8260.15
137_S206_R0.8260.15
84_A189_Y0.8240.15
237_G250_Y0.8210.15
22_S25_E0.8200.15
48_A51_N0.8190.15
271_G274_S0.8190.15
108_L282_G0.8170.15
62_I134_I0.8090.15
228_P269_A0.8080.15
94_D189_Y0.8070.15
35_I40_I0.8050.15
35_I57_T0.8020.15
314_V322_V0.8000.15
3_G44_I0.8000.15
141_V191_D0.8000.15
213_H243_C0.7990.15
75_A105_A0.7900.14
228_P268_M0.7850.14
18_Y62_I0.7790.14
78_I140_K0.7750.14
76_E117_A0.7730.14
205_V225_S0.7720.14
58_L88_P0.7720.14
5_E174_F0.7720.14
74_A324_V0.7710.14
222_T285_H0.7690.14
119_L219_V0.7680.14
4_Y176_Y0.7660.14
43_G53_C0.7650.14
14_V242_E0.7630.14
5_E180_E0.7620.14
119_L134_I0.7620.14
3_G48_A0.7610.14
268_M277_M0.7610.14
7_R87_I0.7600.14
291_A294_S0.7570.14
93_D320_V0.7440.14
17_E39_K0.7440.14
68_C78_I0.7430.14
299_H302_M0.7390.13
205_V259_T0.7370.13
132_I137_S0.7350.13
304_G307_G0.7310.13
222_T289_Q0.7280.13
48_A199_C0.7260.13
74_A77_A0.7240.13
93_D96_K0.7230.13
200_Y215_E0.7200.13
297_P300_V0.7200.13
103_N110_R0.7190.13
34_G164_I0.7180.13
128_A138_A0.7170.13
133_G160_I0.7160.13
234_P243_C0.7160.13
206_R246_N0.7150.13
36_D187_K0.7150.13
27_K44_I0.7130.13
257_G260_G0.7130.13
108_L259_T0.7120.13
50_E105_A0.7110.13
229_T264_H0.7070.13
17_E66_K0.7050.13
16_K58_L0.7030.13
204_D264_H0.6970.13
205_V252_S0.6960.13
229_T280_T0.6950.13
264_H268_M0.6920.13
133_G195_A0.6910.13
11_I26_A0.6900.13
222_T229_T0.6880.13
213_H216_G0.6870.13
259_T285_H0.6870.13
37_V137_S0.6860.13
222_T238_T0.6860.13
25_E28_K0.6850.13
290_F293_S0.6840.13
307_G310_N0.6830.13
264_H289_Q0.6830.13
44_I137_S0.6790.12
117_A236_A0.6780.12
141_V325_E0.6770.12
84_A87_I0.6750.12
62_I78_I0.6730.12
72_A76_E0.6730.12
78_I99_L0.6710.12
277_M281_M0.6710.12
16_K84_A0.6710.12
143_K198_R0.6700.12
175_D216_G0.6680.12
23_L58_L0.6680.12
37_V41_V0.6650.12
189_Y234_P0.6640.12
176_Y179_G0.6630.12
20_I117_A0.6610.12
280_T284_M0.6600.12
297_P302_M0.6580.12
35_I58_L0.6570.12
97_V203_D0.6510.12
137_S197_V0.6480.12
32_D214_H0.6470.12
20_I137_S0.6460.12
13_A22_S0.6450.12
54_W75_A0.6450.12
269_A282_G0.6430.12
228_P259_T0.6430.12
41_V53_C0.6410.12
3_G187_K0.6370.12
216_G246_N0.6370.12
270_A274_S0.6360.12
24_E144_E0.6350.12
169_Y185_K0.6350.12
12_N58_L0.6320.12
74_A106_A0.6320.12
259_T280_T0.6310.12
194_R229_T0.6310.12
56_Y71_A0.6290.12
189_Y277_M0.6290.12
27_K35_I0.6290.12
290_F294_S0.6270.12
259_T268_M0.6250.12
42_K181_L0.6240.12
271_G276_G0.6220.12
253_V267_N0.6200.11
267_N280_T0.6200.11
44_I160_I0.6190.11
304_G309_G0.6190.11
107_M133_G0.6180.11
291_A295_S0.6170.11
272_P276_G0.6170.11
108_L113_T0.6160.11
48_A117_A0.6160.11
12_N16_K0.6130.11
280_T289_Q0.6110.11
316_A322_V0.6100.11
30_C174_F0.6100.11
108_L289_Q0.6100.11
252_S289_Q0.6090.11
10_K13_A0.6080.11
243_C247_G0.6080.11
293_S296_V0.6070.11
33_K51_N0.6060.11
57_T107_M0.6040.11
74_A134_I0.6030.11
257_G261_R0.6030.11
295_S300_V0.6020.11
295_S299_H0.6010.11
108_L264_H0.5980.11
264_H269_A0.5980.11
26_A30_C0.5970.11
108_L222_T0.5950.11
27_K147_R0.5950.11
205_V282_G0.5950.11
75_A165_N0.5940.11
189_Y242_E0.5930.11
4_Y60_A0.5910.11
205_V264_H0.5910.11
254_A257_G0.5890.11
21_A69_K0.5880.11
176_Y213_H0.5880.11
225_S289_Q0.5880.11
159_Y187_K0.5880.11
35_I64_I0.5870.11
274_S278_T0.5860.11
118_F135_A0.5850.11
141_V198_R0.5850.11
48_A137_S0.5840.11
7_R301_E0.5820.11
69_K200_Y0.5820.11
204_D259_T0.5820.11
73_E77_A0.5820.11
229_T232_Q0.5810.11
205_V253_V0.5810.11
204_D253_V0.5800.11
260_G266_D0.5800.11
14_V81_G0.5780.11
108_L225_S0.5780.11
275_Y279_D0.5750.11
268_M282_G0.5740.11
17_E202_A0.5740.11
228_P282_G0.5740.11
13_A191_D0.5730.11
182_K249_K0.5730.11
37_V133_G0.5710.11
138_A212_M0.5710.11
114_K188_A0.5680.11
46_P135_A0.5680.11
315_G321_A0.5670.11
228_P253_V0.5670.11
80_E106_A0.5670.11
242_E277_M0.5650.11
159_Y242_E0.5650.11
51_N94_D0.5650.11
291_A296_V0.5610.11
33_K50_E0.5590.11
134_I212_M0.5590.11
14_V234_P0.5580.11
225_S280_T0.5570.11
304_G310_N0.5560.11
3_G87_I0.5550.11
222_T280_T0.5550.11
205_V228_P0.5550.11
307_G311_N0.5520.10
78_I137_S0.5510.10
162_S199_C0.5500.10
33_K243_C0.5500.10
74_A119_L0.5490.10
40_I43_G0.5490.10
320_V327_A0.5490.10
51_N288_A0.5480.10
295_S302_M0.5480.10
38_Y44_I0.5460.10
81_G128_A0.5460.10
7_R103_N0.5460.10
293_S297_P0.5460.10
256_G260_G0.5450.10
40_I185_K0.5450.10
281_M285_H0.5450.10
296_V300_V0.5450.10
229_T267_N0.5440.10
296_V299_H0.5440.10
13_A20_I0.5430.10
189_Y286_S0.5430.10
36_D48_A0.5430.10
3_G301_E0.5380.10
228_P238_T0.5370.10
143_K200_Y0.5370.10
276_G279_D0.5370.10
60_A263_L0.5360.10
175_D210_A0.5340.10
14_V18_Y0.5330.10
300_V304_G0.5310.10
299_H304_G0.5310.10
161_I201_G0.5300.10
197_V214_H0.5280.10
35_I53_C0.5280.10
8_I20_I0.5260.10
225_S232_Q0.5250.10
73_E97_V0.5250.10
257_G262_T0.5250.10
81_G103_N0.5240.10
96_K178_T0.5240.10
119_L138_A0.5240.10
301_E305_L0.5230.10
50_E88_P0.5220.10
314_V317_T0.5210.10
264_H286_S0.5200.10
147_R195_A0.5200.10
17_E196_K0.5200.10
74_A140_K0.5170.10
253_V285_H0.5150.10
5_E88_P0.5150.10
48_A247_G0.5140.10
292_G295_S0.5130.10
188_A192_G0.5110.10
268_M285_H0.5110.10
144_E162_S0.5110.10
76_E103_N0.5110.10
204_D222_T0.5090.10
291_A297_P0.5090.10
262_T266_D0.5090.10
94_D137_S0.5070.10
18_Y87_I0.5060.10
17_E112_E0.5050.10
76_E106_A0.5020.10
119_L165_N0.5010.10
175_D188_A0.5000.10
69_K250_Y0.5000.10
176_Y197_V0.5000.10
119_L237_G0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k5eA 1 0.1621 72.1 0.979 Contact Map
2fi0A 1 0.1682 55.6 0.981 Contact Map
2ph5A 2 0.4526 41.1 0.983 Contact Map
3ngjA 4 0.5688 38.8 0.983 Contact Map
2k53A 1 0.1682 36.9 0.983 Contact Map
4i6vA 3 0.1713 28.2 0.984 Contact Map
3lapA 6 0.4404 25 0.985 Contact Map
3v4gA 5 0.3976 18.8 0.985 Contact Map
2ljuA 1 0.1713 17.9 0.986 Contact Map
4ioyX 1 0.1193 17.2 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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