GREMLIN Database
NVEALA - NVEALA protein
PFAM: PF14055 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 64 (59)
Sequences: 1508 (1411)
Seq/√Len: 183.7
META: 0.853

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_L34_A3.5151.00
54_Y57_Y2.4131.00
2_K5_K2.3671.00
22_N25_Q2.1021.00
21_V24_S2.0471.00
5_K8_F1.8721.00
54_Y58_G1.7961.00
52_G55_T1.6791.00
53_G57_Y1.6211.00
50_G53_G1.6191.00
18_Y23_S1.5931.00
55_T58_G1.5631.00
46_G49_G1.5591.00
48_C53_G1.5391.00
51_G55_T1.4181.00
38_V49_G1.4121.00
8_F12_I1.3421.00
46_G50_G1.3261.00
4_L7_I1.2931.00
54_Y59_S1.2721.00
48_C51_G1.2701.00
6_I10_A1.2101.00
3_I7_I1.2041.00
50_G56_C1.1771.00
31_S34_A1.1511.00
52_G57_Y1.1401.00
50_G54_Y1.1071.00
5_K12_I1.0901.00
44_G52_G1.0801.00
46_G52_G1.0571.00
46_G55_T1.0391.00
49_G53_G1.0201.00
30_L35_L1.0000.99
55_T59_S0.9480.99
1_K4_L0.9430.99
48_C52_G0.9420.99
47_D52_G0.9410.99
40_A44_G0.9300.99
32_D42_A0.9190.99
51_G58_G0.9180.99
18_Y25_Q0.9040.99
26_K29_N0.8830.99
16_A19_N0.8630.98
12_I16_A0.8540.98
11_A16_A0.8370.98
18_Y22_N0.8340.98
8_F13_A0.8090.97
26_K36_A0.7910.97
49_G54_Y0.7680.97
6_I9_V0.7660.96
51_G54_Y0.7600.96
15_A18_Y0.7510.96
52_G58_G0.7440.96
33_L42_A0.7200.95
30_L36_A0.7130.95
48_C54_Y0.7120.95
31_S36_A0.7120.95
7_I11_A0.6880.94
34_A38_V0.6840.94
44_G49_G0.6790.93
6_I14_A0.6730.93
15_A19_N0.6670.93
22_N28_V0.6490.92
3_I8_F0.6480.92
12_I18_Y0.6420.91
27_N30_L0.6250.90
46_G51_G0.6210.90
50_G58_G0.6160.89
7_I12_I0.6070.89
48_C55_T0.6020.88
49_G52_G0.6020.88
51_G59_S0.5900.87
19_N34_A0.5800.86
21_V25_Q0.5700.85
47_D53_G0.5640.85
13_A17_G0.5600.84
17_G25_Q0.5520.84
18_Y24_S0.5370.82
52_G59_S0.5360.82
30_L42_A0.5290.81
14_A19_N0.5260.81
38_V41_L0.5240.80
35_L38_V0.5220.80
36_A43_Q0.5180.80
43_Q59_S0.5180.80
43_Q50_G0.5130.79
46_G53_G0.5020.78
50_G57_Y0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1nX 1 0.5781 4.3 0.863 Contact Map
3ne5B 3 0 4.2 0.863 Contact Map
2cvcA 1 0.5938 4.1 0.864 Contact Map
2kogA 1 0.3594 3.7 0.867 Contact Map
1xjtA 1 0.7656 3.2 0.87 Contact Map
2a3mA 1 0.5469 3.2 0.871 Contact Map
2qzuA 2 0.6719 3.1 0.872 Contact Map
4wl1A 3 0 3 0.873 Contact Map
3wbhA 2 0.6406 2.6 0.877 Contact Map
2m8rA 1 0.3906 2.5 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0042 seconds.