GREMLIN Database
YIEGIA - YIEGIA protein
PFAM: PF14045 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 281 (280)
Sequences: 525 (377)
Seq/√Len: 22.5
META: 0.535

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_E189_E7.4541.00
157_E197_K4.6631.00
263_I267_K3.8591.00
194_V266_V3.7241.00
121_A133_A3.5801.00
158_P259_I3.5661.00
190_E227_K3.5421.00
168_L251_F3.0121.00
155_D199_K2.9731.00
183_S234_E2.9530.99
154_A196_I2.8710.99
99_G147_G2.8050.99
194_V262_L2.8000.99
122_Y130_G2.7840.99
159_A171_D2.7630.99
156_V267_K2.7500.99
172_D242_D2.7070.99
173_I249_G2.6170.99
208_A241_R2.5960.99
155_D197_K2.5850.99
228_R236_T2.5190.98
10_T35_L2.4870.98
167_L174_Y2.4450.98
10_T39_F2.4420.98
151_G267_K2.3750.97
35_L39_F2.3650.97
220_A262_L2.2930.97
161_I191_G2.1160.95
88_E277_R2.0840.95
91_P218_H2.0440.94
136_I140_I1.9930.93
14_L35_L1.9930.93
8_A134_G1.9910.93
159_A195_I1.9060.91
162_R172_D1.8880.91
192_L259_I1.8860.91
160_K171_D1.8680.91
159_A170_V1.8440.90
242_D247_R1.8430.90
43_A60_V1.8240.89
217_L239_A1.7740.88
157_E171_D1.7710.88
84_L208_A1.7650.88
30_G33_I1.7350.87
52_L55_K1.7250.87
187_I251_F1.6830.85
117_L137_A1.6620.84
166_P177_N1.6580.84
150_I154_A1.6480.84
154_A207_L1.6290.83
78_R98_E1.6130.83
195_I247_R1.5680.81
75_N79_E1.5340.79
21_Y34_H1.5250.79
193_G249_G1.5230.79
192_L262_L1.5160.78
150_I207_L1.4960.77
110_L145_M1.4900.77
158_P192_L1.4800.77
206_T226_V1.4780.77
117_L133_A1.4470.75
36_S80_T1.4360.74
181_P185_E1.4230.74
217_L231_G1.4130.73
34_H104_F1.4110.73
239_A248_V1.4100.73
26_T265_A1.3860.72
88_E214_Q1.3820.72
53_L124_L1.3780.71
206_T277_R1.3580.70
254_P257_K1.3450.69
156_V266_V1.3270.68
60_V118_T1.3080.67
68_Q112_I1.2920.66
60_V65_L1.2850.66
130_G134_G1.2840.66
115_A182_E1.2610.64
220_A266_V1.2390.63
6_I116_L1.2380.63
132_I136_I1.2360.63
244_D258_D1.2280.62
217_L250_L1.2210.62
9_G13_R1.2190.62
169_Y174_Y1.2160.61
21_Y96_Y1.2150.61
52_L56_E1.2140.61
228_R231_G1.2030.61
183_S186_K1.1850.59
31_Y111_V1.1790.59
202_N278_K1.1710.58
230_V240_R1.1670.58
12_A16_M1.1630.58
44_L48_A1.1580.58
65_L267_K1.1440.57
135_I150_I1.1370.56
60_V80_T1.1370.56
278_K281_E1.1330.56
200_N203_A1.1240.55
67_A237_P1.1090.54
264_E267_K1.1090.54
201_D204_R1.1090.54
200_N275_A1.1090.54
117_L129_A1.1080.54
6_I39_F1.0890.53
53_L173_I1.0800.52
182_E185_E1.0750.52
22_R38_G1.0660.51
157_E195_I1.0640.51
44_L222_T1.0570.51
67_A98_E1.0560.51
52_L68_Q1.0540.50
163_F168_L1.0530.50
175_I202_N1.0470.50
79_E83_N1.0450.50
121_A160_K1.0380.49
64_A196_I1.0320.49
38_G44_L1.0270.49
188_L199_K1.0260.48
178_V187_I1.0230.48
80_T122_Y1.0210.48
187_I249_G1.0060.47
159_A193_G1.0030.47
150_I250_L1.0000.47
67_A89_L0.9960.46
30_G103_V0.9950.46
129_A132_I0.9880.46
46_A115_A0.9870.46
165_G173_I0.9850.46
131_I188_L0.9850.46
201_D280_L0.9780.45
196_I216_I0.9740.45
232_E243_L0.9740.45
57_F61_T0.9710.45
10_T52_L0.9680.45
5_G119_S0.9650.44
264_E268_R0.9600.44
114_T117_L0.9590.44
26_T112_I0.9580.44
39_F55_K0.9570.44
183_S232_E0.9560.44
89_L98_E0.9560.44
20_D38_G0.9500.43
12_A60_V0.9290.42
226_V241_R0.9250.42
220_A250_L0.9240.42
186_K232_E0.9240.42
63_L265_A0.9220.41
31_Y118_T0.9220.41
162_R169_Y0.9190.41
16_M73_V0.9180.41
227_K241_R0.9130.41
125_F129_A0.9090.41
82_T112_I0.9090.41
49_V58_T0.9000.40
47_V239_A0.9000.40
36_S58_T0.8990.40
8_A118_T0.8920.39
99_G110_L0.8890.39
85_E240_R0.8880.39
230_V234_E0.8850.39
90_V98_E0.8830.39
42_A269_V0.8760.38
89_L200_N0.8740.38
22_R104_F0.8740.38
140_I144_L0.8720.38
220_A252_I0.8720.38
169_Y249_G0.8710.38
95_A156_V0.8660.38
56_E65_L0.8650.38
117_L155_D0.8640.38
39_F113_F0.8630.38
8_A114_T0.8580.37
110_L254_P0.8500.37
121_A125_F0.8480.37
34_H279_P0.8460.36
229_D243_L0.8440.36
118_T121_A0.8430.36
231_G235_L0.8420.36
186_K227_K0.8410.36
33_I219_D0.8390.36
68_Q72_E0.8370.36
186_K208_A0.8300.35
43_A68_Q0.8300.35
66_A108_N0.8290.35
172_D249_G0.8240.35
259_I263_I0.8230.35
217_L240_R0.8230.35
57_F172_D0.8210.35
19_T26_T0.8180.35
6_I43_A0.8100.34
47_V112_I0.8040.34
29_H58_T0.8000.34
197_K247_R0.7980.33
73_V108_N0.7960.33
24_Y34_H0.7940.33
111_V141_L0.7930.33
30_G206_T0.7920.33
158_P194_V0.7890.33
163_F174_Y0.7880.33
27_Y178_V0.7850.33
163_F188_L0.7800.32
242_D278_K0.7800.32
79_E207_L0.7790.32
4_L118_T0.7790.32
95_A141_L0.7760.32
95_A111_V0.7750.32
11_L185_E0.7700.32
194_V220_A0.7660.32
15_L199_K0.7650.31
113_F191_G0.7640.31
71_R109_Y0.7590.31
184_R268_R0.7580.31
169_Y172_D0.7580.31
96_Y273_E0.7560.31
47_V64_A0.7540.31
2_I264_E0.7490.31
35_L167_L0.7460.30
190_E241_R0.7460.30
12_A115_A0.7450.30
21_Y279_P0.7450.30
8_A80_T0.7440.30
116_L232_E0.7420.30
160_K172_D0.7410.30
7_I131_I0.7390.30
27_Y279_P0.7370.30
98_E237_P0.7370.30
114_T137_A0.7360.30
84_L274_S0.7340.30
231_G253_L0.7330.30
11_L117_L0.7290.29
43_A141_L0.7260.29
84_L116_L0.7210.29
232_E248_V0.7210.29
248_V253_L0.7170.29
256_E260_E0.7150.29
68_Q96_Y0.7120.28
7_I120_L0.7120.28
235_L253_L0.7100.28
134_G214_Q0.7060.28
119_S122_Y0.7060.28
210_L230_V0.7050.28
156_V260_E0.7010.28
74_R92_R0.7000.28
30_G38_G0.6970.28
116_L120_L0.6940.27
219_D226_V0.6940.27
173_I247_R0.6920.27
61_T224_L0.6890.27
42_A83_N0.6890.27
57_F130_G0.6880.27
85_E227_K0.6860.27
177_N224_L0.6860.27
115_A166_P0.6840.27
68_Q223_I0.6840.27
57_F143_R0.6810.27
12_A143_R0.6800.27
65_L113_F0.6790.27
172_D193_G0.6780.27
29_H36_S0.6780.27
271_V274_S0.6740.26
47_V58_T0.6740.26
4_L207_L0.6720.26
227_K253_L0.6720.26
19_T31_Y0.6700.26
140_I143_R0.6700.26
186_K190_E0.6660.26
111_V252_I0.6660.26
102_K146_S0.6610.26
83_N126_N0.6600.26
15_L46_A0.6590.26
48_A64_A0.6580.25
52_L254_P0.6580.25
204_R227_K0.6570.25
194_V223_I0.6550.25
143_R154_A0.6540.25
91_P160_K0.6540.25
201_D245_T0.6510.25
167_L218_H0.6490.25
186_K241_R0.6450.25
161_I181_P0.6420.25
36_S111_V0.6410.25
219_D247_R0.6400.25
78_R88_E0.6400.25
4_L103_V0.6400.25
87_T196_I0.6390.25
26_T87_T0.6340.24
26_T102_K0.6340.24
10_T72_E0.6340.24
35_L145_M0.6290.24
37_L67_A0.6270.24
85_E111_V0.6270.24
208_A226_V0.6260.24
150_I157_E0.6250.24
29_H99_G0.6240.24
131_I181_P0.6190.23
234_E261_K0.6190.23
44_L200_N0.6190.23
151_G268_R0.6190.23
209_N219_D0.6170.23
164_D169_Y0.6160.23
37_L68_Q0.6160.23
246_G279_P0.6160.23
190_E247_R0.6150.23
169_Y191_G0.6150.23
21_Y27_Y0.6130.23
131_I135_I0.6130.23
190_E208_A0.6120.23
21_Y33_I0.6120.23
27_Y60_V0.6110.23
71_R177_N0.6100.23
44_L66_A0.6080.23
132_I185_E0.6070.23
17_L21_Y0.6070.23
209_N226_V0.6060.23
33_I269_V0.6060.23
164_D244_D0.6060.23
150_I267_K0.6030.23
139_L224_L0.6010.23
193_G262_L0.6010.23
224_L262_L0.6000.23
18_R130_G0.5970.22
159_A162_R0.5940.22
245_T266_V0.5930.22
214_Q231_G0.5890.22
60_V104_F0.5890.22
21_Y40_I0.5880.22
82_T86_E0.5880.22
131_I172_D0.5880.22
23_Q177_N0.5870.22
22_R34_H0.5870.22
36_S83_N0.5860.22
231_G236_T0.5860.22
67_A90_V0.5850.22
24_Y275_A0.5840.22
219_D269_V0.5840.22
11_L266_V0.5810.22
52_L185_E0.5810.22
35_L106_A0.5810.22
201_D256_E0.5800.22
172_D196_I0.5790.22
39_F131_I0.5790.22
44_L68_Q0.5780.22
56_E60_V0.5760.21
72_E75_N0.5750.21
102_K223_I0.5750.21
3_L260_E0.5740.21
87_T94_A0.5730.21
143_R199_K0.5730.21
52_L253_L0.5730.21
157_E160_K0.5720.21
29_H141_L0.5690.21
220_A248_V0.5690.21
243_L253_L0.5680.21
175_I181_P0.5680.21
37_L202_N0.5670.21
151_G186_K0.5650.21
98_E236_T0.5640.21
158_P263_I0.5640.21
34_H38_G0.5630.21
60_V187_I0.5630.21
270_P273_E0.5620.21
187_I193_G0.5620.21
177_N232_E0.5600.21
186_K191_G0.5570.21
141_L223_I0.5560.21
147_G272_L0.5540.20
68_Q115_A0.5510.20
48_A51_A0.5490.20
4_L131_I0.5490.20
20_D71_R0.5490.20
204_R241_R0.5470.20
265_A280_L0.5460.20
35_L263_I0.5460.20
120_L144_L0.5430.20
171_D269_V0.5420.20
89_L237_P0.5390.20
133_A137_A0.5380.20
132_I170_V0.5370.20
189_E260_E0.5330.20
8_A160_K0.5330.20
174_Y232_E0.5330.20
200_N210_L0.5320.19
121_A260_E0.5310.19
41_A213_R0.5310.19
2_I10_T0.5310.19
257_K266_V0.5300.19
53_L220_A0.5290.19
170_V233_P0.5280.19
52_L264_E0.5280.19
186_K244_D0.5280.19
11_L14_L0.5270.19
40_I176_M0.5240.19
239_A250_L0.5240.19
88_E279_P0.5240.19
90_V210_L0.5240.19
19_T102_K0.5230.19
23_Q255_Q0.5220.19
49_V120_L0.5180.19
124_L138_L0.5180.19
21_Y104_F0.5170.19
163_F244_D0.5160.19
79_E82_T0.5160.19
195_I249_G0.5130.19
25_P28_P0.5130.19
254_P270_P0.5120.19
5_G120_L0.5110.19
142_K178_V0.5110.19
229_D236_T0.5100.19
132_I135_I0.5080.18
65_L189_E0.5080.18
129_A204_R0.5080.18
150_I183_S0.5080.18
3_L136_I0.5060.18
186_K234_E0.5040.18
139_L181_P0.5030.18
99_G231_G0.5020.18
85_E141_L0.5020.18
172_D244_D0.5010.18
185_E188_L0.5010.18
103_V208_A0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3af5A 1 0.4093 17 0.977 Contact Map
4px7A 1 0.242 13.3 0.978 Contact Map
3aqpA 1 0.4235 11 0.979 Contact Map
2m20A 2 0.2135 8.9 0.98 Contact Map
3qe7A 2 0.4306 7.8 0.98 Contact Map
4citA 1 0.3986 7 0.981 Contact Map
2ycbA 2 0.4164 5.9 0.981 Contact Map
3aqoA 1 0.2883 5.9 0.981 Contact Map
2p1lB 2 0.0854 5.5 0.981 Contact Map
4oh3A 2 0.2384 5.5 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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