GREMLIN Database
Lipoprotein_21 - LppP/LprE lipoprotein
PFAM: PF14041 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (79)
Sequences: 2027 (1346)
Seq/√Len: 151.4
META: 0.857

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_Y82_F3.9651.00
27_A60_L2.8521.00
61_E77_T2.7381.00
31_V36_A2.4101.00
39_D62_Y2.1171.00
69_D75_S2.0651.00
57_T83_R2.0441.00
61_E79_T1.7851.00
31_V84_W1.7561.00
69_D74_P1.7051.00
51_V61_E1.7041.00
66_R75_S1.5861.00
39_D44_S1.5761.00
59_T81_R1.5731.00
21_M71_L1.5711.00
54_G57_T1.5321.00
19_D22_C1.5261.00
66_R76_G1.4561.00
20_G23_R1.4301.00
19_D23_R1.3871.00
49_R61_E1.3781.00
7_A10_S1.3561.00
70_P73_C1.3221.00
25_Y47_I1.3061.00
26_Q38_T1.3051.00
57_T81_R1.2871.00
23_R71_L1.2741.00
8_T32_G1.2611.00
21_M25_Y1.1961.00
35_F38_T1.1781.00
64_R76_G1.1391.00
19_D24_P1.1331.00
12_V15_G1.1281.00
83_R86_G1.0830.99
65_Y69_D1.0820.99
53_Q58_V1.0810.99
26_Q39_D1.0700.99
47_I63_A1.0630.99
72_C75_S0.9720.99
26_Q43_P0.9530.98
6_C10_S0.9510.98
36_A41_P0.9230.98
44_S64_R0.9220.98
38_T41_P0.9050.98
10_S82_F0.8980.98
65_Y74_P0.8880.97
53_Q56_D0.8840.97
69_D72_C0.8790.97
31_V34_R0.8630.97
59_T79_T0.8470.97
27_A39_D0.8390.96
46_S71_L0.8360.96
8_T55_D0.8330.96
15_G19_D0.8190.96
52_L59_T0.8170.96
26_Q33_G0.8170.96
53_Q57_T0.8150.96
28_F65_Y0.8110.96
13_L16_T0.8090.95
27_A42_D0.8080.95
78_A81_R0.8070.95
51_V59_T0.7990.95
18_G55_D0.7940.95
10_S33_G0.7930.95
30_F35_F0.7900.95
51_V55_D0.7850.95
52_L58_V0.7780.94
27_A50_V0.7760.94
21_M24_P0.7680.94
15_G28_F0.7670.94
20_G71_L0.7670.94
12_V17_A0.7660.94
36_A39_D0.7650.94
77_T81_R0.7650.94
56_D83_R0.7590.94
10_S13_L0.7590.94
69_D73_C0.7570.94
40_S82_F0.7400.93
71_L75_S0.7260.92
40_S43_P0.7230.92
22_C35_F0.7090.91
14_V27_A0.7070.91
29_F39_D0.6990.91
14_V60_L0.6880.90
28_F31_V0.6840.90
52_L55_D0.6780.89
27_A58_V0.6690.89
66_R69_D0.6600.88
51_V81_R0.6570.88
50_V54_G0.6560.88
20_G46_S0.6490.87
51_V63_A0.6480.87
44_S47_I0.6440.87
8_T31_V0.6420.87
28_F44_S0.6420.87
47_I57_T0.6390.86
46_S63_A0.6370.86
37_G40_S0.6150.84
64_R78_A0.6100.84
49_R58_V0.6100.84
10_S15_G0.6070.83
29_F64_R0.5920.82
10_S31_V0.5890.81
44_S62_Y0.5890.81
40_S44_S0.5880.81
63_A77_T0.5850.81
24_P46_S0.5670.79
47_I60_L0.5610.78
26_Q44_S0.5550.78
7_A13_L0.5480.77
17_A24_P0.5480.77
13_L17_A0.5410.76
33_G56_D0.5330.75
45_A55_D0.5330.75
20_G24_P0.5140.72
52_L57_T0.5140.72
35_F41_P0.5060.71
13_L58_V0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zf9A 1 0.8621 4.4 0.916 Contact Map
2yoyA 1 0.7816 4.3 0.916 Contact Map
4iu3A 1 0.7931 3.9 0.918 Contact Map
3n2zB 2 0.977 3.1 0.922 Contact Map
4qtqA 1 0.8966 3 0.923 Contact Map
3d7rA 1 0.931 2.9 0.923 Contact Map
4l3nA 1 0.7701 2.9 0.923 Contact Map
3lsoA 1 0.9195 2.9 0.924 Contact Map
2pqfA 2 0.8276 2.8 0.924 Contact Map
4a02A 1 0.7931 2.7 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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