GREMLIN Database
DNase_NucA_NucB - Deoxyribonuclease NucA/NucB
PFAM: PF14040 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 113 (102)
Sequences: 1076 (941)
Seq/√Len: 93.2
META: 0.682

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_D80_R3.7821.00
61_D88_R3.6021.00
5_R16_E2.9411.00
14_H78_S2.8561.00
40_R68_A2.3961.00
28_T72_E2.2251.00
70_T109_F2.1831.00
69_S98_Y2.1411.00
11_I82_I2.0941.00
11_I86_D2.0891.00
10_E86_D1.9471.00
62_R81_Y1.9011.00
93_S98_Y1.7861.00
92_G96_N1.7851.00
74_G77_A1.7041.00
62_R79_V1.6951.00
39_N43_A1.6301.00
104_P107_D1.6201.00
61_D87_N1.5821.00
8_Y89_G1.5661.00
38_A42_A1.5511.00
31_R105_D1.5251.00
19_Q65_Y1.5221.00
15_I19_Q1.5131.00
28_T108_K1.5021.00
27_L65_Y1.4451.00
15_I67_F1.4100.99
84_P88_R1.3990.99
10_E83_P1.3770.99
103_I107_D1.3730.99
44_L62_R1.3480.99
11_I90_A1.3290.99
67_F94_L1.3200.99
61_D84_P1.2960.99
98_Y103_I1.2850.99
60_K81_Y1.2350.98
95_G99_R1.1940.98
39_N44_L1.1660.98
21_A78_S1.1620.98
16_E20_A1.1570.98
51_K81_Y1.1510.98
13_Q17_D1.1330.97
89_G92_G1.1270.97
71_K105_D1.1210.97
93_S97_F1.1140.97
24_P27_L1.0970.97
24_P65_Y1.0860.96
29_I69_S1.0680.96
92_G95_G1.0570.96
30_D35_G1.0480.96
13_Q16_E1.0470.96
11_I87_N1.0320.95
87_N91_G1.0260.95
8_Y93_S1.0170.95
45_R62_R1.0090.95
35_G39_N1.0050.95
82_I90_A1.0000.94
87_N90_A0.9870.94
44_L48_I0.9850.94
86_D90_A0.9810.94
88_R92_G0.9790.94
30_D39_N0.9670.93
67_F70_T0.9420.92
25_S110_R0.9330.92
19_Q25_S0.9190.92
12_A15_I0.9070.91
5_R12_A0.9060.91
29_I103_I0.8870.90
82_I86_D0.8870.90
27_L70_T0.8800.90
12_A19_Q0.8750.89
28_T31_R0.8720.89
97_F101_R0.8370.87
14_H17_D0.8290.87
60_K83_P0.8220.86
94_L97_F0.8180.86
12_A16_E0.8130.86
94_L98_Y0.7870.84
61_D90_A0.7690.82
47_G50_T0.7670.82
39_N68_A0.7630.82
65_Y70_T0.7610.82
61_D92_G0.7610.82
89_G93_S0.7590.82
42_A75_A0.7230.78
45_R48_I0.7190.78
17_D78_S0.7180.78
44_L47_G0.7150.78
84_P87_N0.7130.77
95_G101_R0.7120.77
10_E13_Q0.6960.76
59_G84_P0.6950.76
42_A45_R0.6950.76
18_A21_A0.6940.75
26_V110_R0.6940.75
29_I39_N0.6930.75
72_E108_K0.6860.75
83_P86_D0.6830.74
32_D37_D0.6700.73
5_R15_I0.6550.71
18_A65_Y0.6530.71
102_R107_D0.6290.68
29_I105_D0.6270.68
8_Y87_N0.6240.67
10_E17_D0.6230.67
11_I15_I0.6230.67
37_D41_K0.6210.67
38_A41_K0.6120.66
33_S44_L0.6120.66
15_I63_D0.6040.65
64_E91_G0.6010.65
104_P109_F0.5930.64
13_Q20_A0.5890.63
86_D89_G0.5890.63
9_P12_A0.5880.63
97_F102_R0.5860.63
45_R79_V0.5800.62
44_L50_T0.5780.62
28_T106_G0.5780.62
69_S94_L0.5780.62
36_A44_L0.5720.61
63_D90_A0.5660.60
9_P86_D0.5620.59
30_D71_K0.5620.59
30_D105_D0.5620.59
67_F111_V0.5600.59
101_R104_P0.5560.59
11_I67_F0.5540.58
25_S58_P0.5540.58
14_H18_A0.5530.58
48_I81_Y0.5500.58
25_S60_K0.5450.57
49_P81_Y0.5420.57
50_T62_R0.5390.56
23_K76_G0.5370.56
7_K10_E0.5360.56
5_R8_Y0.5300.55
10_E60_K0.5280.55
14_H80_R0.5280.55
85_S92_G0.5250.54
18_A24_P0.5240.54
12_A97_F0.5230.54
98_Y109_F0.5190.54
15_I90_A0.5170.53
12_A17_D0.5090.52
57_P60_K0.5080.52
31_R36_A0.5070.52
35_G70_T0.5070.52
33_S39_N0.5030.51
70_T98_Y0.5030.51
87_N95_G0.5020.51
102_R110_R0.5020.51
96_N101_R0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xqyA 1 0.4779 8.1 0.927 Contact Map
2cmyB 1 0.1858 6.6 0.93 Contact Map
3b9tA 4 0.3628 5.6 0.932 Contact Map
3ml4A 2 0.2566 3.9 0.938 Contact Map
2mc5A 1 0.2301 2.9 0.941 Contact Map
2plxB 1 0.2301 2.6 0.943 Contact Map
2l66A 2 0.3186 2.6 0.943 Contact Map
4go6B 3 0.2655 2.2 0.945 Contact Map
1olgA 3 0.1239 2.2 0.945 Contact Map
2peqA 2 0.531 2 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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