GREMLIN Database
YlzJ - YlzJ-like protein
PFAM: PF14035 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 65 (65)
Sequences: 1203 (1030)
Seq/√Len: 127.7
META: 0.692

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_E42_R3.4571.00
29_V53_D2.7291.00
50_D53_D2.2021.00
7_L11_F2.1461.00
25_E30_T2.0971.00
22_Q35_P2.0241.00
23_E32_L1.8401.00
1_L5_M1.8291.00
32_L45_R1.8211.00
48_S51_P1.7601.00
35_P41_Y1.6891.00
42_R64_I1.6271.00
21_Y32_L1.6021.00
6_P9_L1.5631.00
29_V46_L1.4901.00
40_Q64_I1.4751.00
43_I63_S1.4611.00
1_L10_V1.4151.00
36_L64_I1.3881.00
34_E44_V1.3541.00
30_T47_L1.3501.00
56_N59_L1.2881.00
26_Y59_L1.2881.00
36_L42_R1.2781.00
37_G40_Q1.2611.00
33_V41_Y1.2441.00
24_I33_V1.2180.99
46_L59_L1.2090.99
4_I9_L1.1780.99
19_P34_E1.1660.99
5_M9_L1.1570.99
48_S53_D1.1170.99
23_E47_L1.0890.99
36_L40_Q1.0640.99
15_E24_I1.0210.98
7_L10_V1.0210.98
5_M10_V1.0200.98
31_L43_I0.9700.97
29_V59_L0.9700.97
23_E45_R0.9540.97
31_L59_L0.9200.96
29_V43_I0.9170.96
38_D41_Y0.8960.96
15_E19_P0.8640.95
26_Y31_L0.8620.95
9_L12_E0.8370.94
27_G58_E0.8190.93
2_Y51_P0.8130.93
23_E30_T0.8040.93
18_E21_Y0.7970.92
29_V50_D0.7930.92
21_Y44_V0.7910.92
31_L49_T0.7330.89
57_P60_Q0.7180.88
1_L49_T0.7120.87
27_G59_L0.7010.86
34_E43_I0.6910.86
23_E27_G0.6850.85
46_L60_Q0.6690.84
10_V14_E0.6640.83
21_Y34_E0.6640.83
4_I7_L0.6620.83
22_Q40_Q0.6590.83
46_L53_D0.6590.83
12_E27_G0.6520.82
3_T7_L0.6410.81
58_E63_S0.6370.81
36_L54_Y0.6350.81
26_Y58_E0.6330.80
19_P42_R0.6300.80
22_Q33_V0.6270.80
17_E20_E0.6270.80
20_E35_P0.6210.79
10_V53_D0.6180.79
29_V56_N0.6170.79
11_F14_E0.6100.78
3_T9_L0.6030.77
40_Q60_Q0.6000.77
24_I31_L0.6000.77
3_T29_V0.5940.76
51_P54_Y0.5900.76
3_T10_V0.5890.75
25_E29_V0.5880.75
19_P36_L0.5830.75
11_F41_Y0.5820.75
2_Y9_L0.5750.74
44_V54_Y0.5610.72
52_Q63_S0.5470.70
20_E64_I0.5450.70
9_L13_G0.5440.70
43_I60_Q0.5420.69
53_D56_N0.5350.68
39_G59_L0.5320.68
33_V65_I0.5310.68
2_Y18_E0.5290.67
43_I59_L0.5160.66
14_E17_E0.5040.64
21_Y46_L0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pbtA 1 0.9538 28.3 0.845 Contact Map
3equA 1 0.9538 26.2 0.847 Contact Map
4bjpA 2 0.9538 24 0.85 Contact Map
3ue3A 1 0.9538 19.9 0.855 Contact Map
4ztkA 1 0.9538 18.3 0.858 Contact Map
4ovdA 2 0.9077 18.1 0.859 Contact Map
1qmeA 1 0.9538 15.5 0.862 Contact Map
1dzfA 1 0.7692 12.6 0.868 Contact Map
4ye5A 1 0.9538 12 0.869 Contact Map
4r23A 1 0.8615 11.1 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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