GREMLIN Database
Spore_YtrH - Sporulation protein YtrH
PFAM: PF14034 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 99 (99)
Sequences: 557 (371)
Seq/√Len: 37.3
META: 0.578

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_G42_L4.4641.00
56_D96_W2.9061.00
44_I48_V2.8051.00
6_F89_T2.5791.00
20_G38_L2.2390.99
2_L82_S2.2220.99
43_K87_A2.1620.99
42_L49_A1.9630.98
10_F14_L1.9370.98
12_V49_A1.8550.98
23_G47_I1.7620.97
77_I81_L1.7550.97
13_V17_S1.6730.96
9_A71_S1.6080.95
10_F90_G1.6060.95
37_R41_S1.6010.94
88_H92_L1.5940.94
12_V80_I1.5500.93
29_Q73_L1.5150.93
49_A56_D1.4780.92
48_V58_I1.4650.91
24_A74_I1.4630.91
24_A34_T1.4140.90
96_W99_G1.4050.89
47_I51_I1.4030.89
5_D51_I1.3820.89
61_I84_F1.3430.87
39_A43_K1.3320.87
29_Q34_T1.3130.86
55_F64_G1.3070.86
29_Q65_L1.2910.85
29_Q37_R1.2890.85
54_T80_I1.2790.84
46_A90_G1.2190.81
21_G24_A1.2060.81
38_L42_L1.1830.79
9_A13_V1.1560.78
10_F19_I1.1420.77
39_A91_Y1.1410.77
84_F90_G1.1390.77
10_F93_L1.1330.76
54_T66_F1.0960.74
33_T37_R1.0940.74
3_I66_F1.0850.73
2_L78_L1.0670.72
77_I80_I1.0660.72
40_E59_R1.0590.71
39_A94_I1.0570.71
70_L74_I1.0440.70
22_L25_F1.0150.68
59_R79_Y1.0130.68
55_F58_I0.9900.66
78_L82_S0.9780.65
12_V87_A0.9660.64
21_G91_Y0.9630.64
35_M94_I0.9460.63
42_L75_K0.9430.62
21_G35_M0.9430.62
1_K63_S0.9180.60
43_K88_H0.9030.59
54_T75_K0.8960.58
32_L42_L0.8910.58
66_F69_E0.8820.57
17_S42_L0.8810.57
13_V61_I0.8770.57
31_P43_K0.8720.56
19_I38_L0.8530.55
16_G69_E0.8530.55
88_H91_Y0.8510.54
12_V58_I0.8490.54
65_L85_L0.8360.53
11_G15_G0.8240.52
54_T57_T0.8230.52
64_G73_L0.8220.52
28_G55_F0.8140.51
6_F68_G0.8090.51
21_G94_I0.7980.50
14_L36_L0.7970.50
20_G61_I0.7940.49
59_R65_L0.7930.49
61_I93_L0.7880.49
7_F30_P0.7860.49
26_L81_L0.7830.48
30_P44_I0.7780.48
13_V72_D0.7660.47
65_L72_D0.7660.47
63_S72_D0.7620.46
58_I80_I0.7470.45
51_I98_T0.7430.45
3_I36_L0.7430.45
33_T57_T0.7390.44
73_L93_L0.7360.44
59_R62_E0.7310.44
13_V82_S0.7230.43
45_W75_K0.7230.43
66_F84_F0.7210.43
5_D41_S0.7210.43
59_R63_S0.7210.43
60_V66_F0.7160.42
32_L64_G0.7150.42
8_I23_G0.7120.42
48_V90_G0.7100.42
46_A60_V0.7020.41
49_A63_S0.7010.41
10_F20_G0.6990.41
66_F73_L0.6870.40
9_A26_L0.6850.40
26_L98_T0.6810.39
65_L71_S0.6670.38
47_I81_L0.6540.37
74_I85_L0.6440.36
14_L69_E0.6440.36
77_I99_G0.6430.36
6_F38_L0.6400.36
7_F50_A0.6370.36
38_L82_S0.6350.36
51_I58_I0.6330.35
49_A60_V0.6290.35
47_I53_G0.6240.35
83_A86_G0.6160.34
77_I85_L0.6080.33
25_F32_L0.6050.33
74_I97_L0.5990.33
79_Y82_S0.5960.33
17_S67_E0.5950.32
58_I82_S0.5900.32
1_K79_Y0.5840.32
5_D56_D0.5830.32
3_I27_T0.5820.31
41_S65_L0.5760.31
5_D96_W0.5750.31
75_K79_Y0.5730.31
59_R70_L0.5710.31
69_E85_L0.5550.29
63_S73_L0.5550.29
2_L79_Y0.5510.29
40_E90_G0.5500.29
35_M68_G0.5390.28
74_I78_L0.5370.28
47_I58_I0.5360.28
43_K91_Y0.5350.28
17_S89_T0.5340.28
30_P46_A0.5310.28
19_I93_L0.5210.27
17_S76_Q0.5130.26
18_L78_L0.5080.26
14_L18_L0.5030.26
49_A82_S0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3llqA 3 0.8788 3 0.945 Contact Map
3tdsE 3 0.404 2.8 0.946 Contact Map
4u2pA 4 0.9798 2.7 0.946 Contact Map
3zojA 3 0.8687 2.7 0.947 Contact Map
3kcuA 3 0.303 2.4 0.948 Contact Map
1geqA 1 0.4343 2.4 0.948 Contact Map
2ih3C 4 0.3333 2.4 0.948 Contact Map
4fc4A 3 0.2929 2.3 0.948 Contact Map
1q2zA 1 0.4646 2.2 0.949 Contact Map
1j4nA 4 0.8687 2.2 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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