DUF4246 - PFAM28P - GREMLIN Contacts

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DUF4246 - Protein of unknown function (DUF4246)

PFAM:	PF14033	Sequences: PPLTLRELAMMQLMNAITDKPDWWEKVFDEEIVAKWRAEALAQGEDDLTEAMVDYCLAELRDKAKLFEETGIVSVLDAGSGVWKSDTLVPDELRSRLRAAVAPLEDVPEAEKDWHPGSDGQVLDLVHPSLFPLVYGRTRVLPDGVVGLDDCLESCGKGEVIPVPPDEETSRYFFSEKFQWLPCDVEVSEDGGVKITSYINNLHPEKHRELYSVIEKLIARAIPLWERVLTDLKLRGPRPLRIEEEDEEDPEYEPPEDEDDEDDDERYEEWEENRRPVVLPEPGEFFPPPEPPPYDEPKPVDLREDFRGRGLQVIVKLANIHLTPEKPEYPGGSWHVEGMLNEHIVATALYYYDSENITESRLSFRQAVDDPDLGEEIDYEQDDDEGLEEVYGLEDEGPLNQELGSVETREGRLLAFPNILQHRVSPFELADPTKPGHRKILALFLVDPHIRIISTANVPPQQPDWWAEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	469 (461)
Sequences:	560 (434)
Seq/√Len:	20.2
META:	0.071

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
217_L	441_L	7.132	1.00
428_E	432_P	6.859	1.00
328_E	428_E	5.455	1.00
221_A	348_A	4.974	1.00
86_D	412_R	4.040	1.00
94_R	411_G	3.780	1.00
22_D	25_E	3.697	1.00
133_L	455_T	3.560	1.00
218_I	443_L	3.541	1.00
184_D	456_A	3.506	1.00
228_V	415_A	3.499	1.00
14_M	18_T	3.488	1.00
353_D	437_H	3.289	1.00
302_L	306_F	3.203	1.00
440_I	444_F	3.189	1.00
101_V	317_L	3.155	1.00
33_V	53_V	3.019	0.99
96_R	216_K	2.926	0.99
183_C	195_I	2.882	0.99
20_K	39_E	2.841	0.99
49_T	52_M	2.709	0.98
355_E	434_K	2.638	0.98
105_E	439_K	2.439	0.97
319_N	439_K	2.421	0.97
439_K	444_F	2.370	0.96
193_V	219_A	2.334	0.96
100_A	213_V	2.295	0.96
424_V	438_R	2.282	0.96
226_E	301_D	2.271	0.95
127_H	318_A	2.191	0.94
114_W	408_T	2.188	0.94
91_D	94_R	2.121	0.93
351_Y	408_T	2.120	0.93
312_Q	454_S	2.057	0.92
359_E	407_E	2.055	0.92
351_Y	424_V	2.054	0.92
114_W	123_L	2.031	0.92
26_K	115_H	2.030	0.92
119_D	326_K	2.024	0.92
187_V	193_V	1.980	0.91
89_V	220_R	1.923	0.89
187_V	310_G	1.916	0.89
129_S	180_W	1.888	0.88
98_R	353_D	1.881	0.88
127_H	424_V	1.850	0.87
20_K	438_R	1.849	0.87
332_G	438_R	1.842	0.87
14_M	63_K	1.842	0.87
93_L	435_P	1.838	0.87
363_S	425_S	1.837	0.87
217_L	350_Y	1.832	0.87
109_E	112_K	1.827	0.87
15_N	19_D	1.821	0.86
127_H	381_Q	1.818	0.86
318_A	337_E	1.802	0.86
332_G	351_Y	1.788	0.85
175_S	178_F	1.785	0.85
318_A	424_V	1.769	0.85
202_L	211_Y	1.748	0.84
49_T	281_E	1.732	0.84
121_Q	330_P	1.726	0.83
332_G	424_V	1.716	0.83
94_R	410_E	1.714	0.83
349_L	442_A	1.701	0.82
361_R	405_S	1.688	0.82
185_V	195_I	1.686	0.82
115_H	122_V	1.685	0.82
147_G	150_D	1.685	0.82
351_Y	362_L	1.682	0.82
33_V	61_R	1.681	0.82
38_A	42_A	1.658	0.81
118_S	329_Y	1.648	0.80
113_D	424_V	1.647	0.80
318_A	381_Q	1.644	0.80
358_T	437_H	1.605	0.78
218_I	225_W	1.565	0.77
363_S	423_R	1.554	0.76
221_A	347_T	1.545	0.76
56_C	81_G	1.538	0.75
122_V	416_F	1.535	0.75
113_D	351_Y	1.532	0.75
175_S	339_M	1.523	0.75
424_V	442_A	1.521	0.75
108_P	112_K	1.520	0.74
318_A	332_G	1.511	0.74
127_H	180_W	1.510	0.74
115_H	127_H	1.501	0.74
421_Q	438_R	1.501	0.74
37_R	54_D	1.500	0.73
351_Y	438_R	1.494	0.73
20_K	127_H	1.492	0.73
127_H	332_G	1.482	0.73
41_L	50_E	1.476	0.72
35_K	113_D	1.471	0.72
20_K	26_K	1.471	0.72
26_K	424_V	1.466	0.72
331_G	426_P	1.461	0.71
116_P	127_H	1.457	0.71
71_G	97_L	1.443	0.70
422_H	438_R	1.432	0.70
120_G	326_K	1.424	0.69
453_I	457_N	1.420	0.69
316_K	332_G	1.404	0.68
215_E	457_N	1.392	0.68
329_Y	352_Y	1.391	0.68
381_Q	438_R	1.390	0.68
20_K	424_V	1.379	0.67
365_R	421_Q	1.377	0.67
318_A	444_F	1.377	0.67
30_E	61_R	1.374	0.67
270_W	458_V	1.373	0.67
337_E	424_V	1.372	0.66
358_T	427_F	1.371	0.66
225_W	348_A	1.368	0.66
26_K	127_H	1.368	0.66
63_K	83_W	1.367	0.66
115_H	332_G	1.360	0.66
113_D	332_G	1.355	0.65
18_T	63_K	1.354	0.65
26_K	35_K	1.350	0.65
19_D	84_K	1.350	0.65
334_W	365_R	1.346	0.65
53_V	56_C	1.343	0.65
26_K	337_E	1.329	0.64
6_R	10_M	1.329	0.64
127_H	360_S	1.328	0.64
115_H	318_A	1.327	0.64
258_E	262_D	1.327	0.64
26_K	351_Y	1.325	0.64
127_H	438_R	1.309	0.63
122_V	129_S	1.308	0.63
312_Q	452_I	1.308	0.63
133_L	138_T	1.291	0.62
33_V	138_T	1.286	0.61
133_L	140_V	1.285	0.61
113_D	316_K	1.284	0.61
102_A	328_E	1.278	0.61
76_L	138_T	1.275	0.61
94_R	350_Y	1.270	0.60
107_V	112_K	1.266	0.60
360_S	424_V	1.262	0.60
337_E	351_Y	1.260	0.60
320_I	329_Y	1.250	0.59
113_D	116_P	1.243	0.59
115_H	424_V	1.242	0.59
319_N	352_Y	1.234	0.58
15_N	84_K	1.232	0.58
20_K	422_H	1.226	0.58
115_H	444_F	1.223	0.57
343_H	450_I	1.222	0.57
269_E	273_N	1.221	0.57
332_G	337_E	1.219	0.57
312_Q	451_R	1.219	0.57
333_S	424_V	1.217	0.57
206_K	468_E	1.216	0.57
113_D	438_R	1.213	0.57
181_L	458_V	1.210	0.57
438_R	442_A	1.210	0.57
11_M	75_V	1.205	0.56
381_Q	442_A	1.200	0.56
429_L	436_G	1.193	0.55
20_K	32_I	1.191	0.55
134_V	138_T	1.191	0.55
27_V	64_A	1.184	0.55
74_S	226_E	1.182	0.55
332_G	381_Q	1.179	0.55
20_K	332_G	1.169	0.54
318_A	442_A	1.168	0.54
195_I	218_I	1.161	0.53
18_T	84_K	1.160	0.53
352_Y	439_K	1.157	0.53
39_E	438_R	1.157	0.53
408_T	424_V	1.153	0.53
337_E	416_F	1.149	0.53
116_P	444_F	1.145	0.52
20_K	35_K	1.144	0.52
115_H	381_Q	1.144	0.52
359_E	383_D	1.144	0.52
35_K	39_E	1.143	0.52
116_P	362_L	1.142	0.52
55_Y	391_Y	1.141	0.52
118_S	335_H	1.141	0.52
24_W	67_F	1.138	0.52
154_S	157_K	1.136	0.52
258_E	263_D	1.131	0.51
26_K	318_A	1.124	0.51
116_P	124_D	1.122	0.51
39_E	422_H	1.121	0.51
306_F	449_H	1.120	0.51
358_T	430_A	1.110	0.50
143_D	161_I	1.110	0.50
127_H	351_Y	1.107	0.50
33_V	240_L	1.107	0.50
225_W	415_A	1.106	0.50
323_T	360_S	1.096	0.49
411_G	420_L	1.095	0.49
88_L	413_L	1.092	0.49
329_Y	427_F	1.091	0.49
317_L	441_L	1.090	0.49
114_W	193_V	1.088	0.49
454_S	465_W	1.079	0.48
32_I	35_K	1.079	0.48
13_L	17_I	1.078	0.48
35_K	318_A	1.078	0.48
104_L	125_L	1.075	0.48
140_V	453_I	1.073	0.48
13_L	120_G	1.071	0.47
115_H	316_K	1.070	0.47
39_E	381_Q	1.068	0.47
39_E	318_A	1.067	0.47
257_D	263_D	1.062	0.47
124_D	127_H	1.056	0.47
115_H	351_Y	1.056	0.47
91_D	95_S	1.051	0.46
329_Y	440_I	1.050	0.46
347_T	414_L	1.049	0.46
124_D	444_F	1.048	0.46
387_L	390_V	1.047	0.46
105_E	319_N	1.042	0.46
102_A	106_D	1.039	0.45
180_W	344_I	1.031	0.45
362_L	442_A	1.017	0.44
424_V	440_I	1.014	0.44
60_L	341_N	1.009	0.43
15_N	18_T	1.005	0.43
39_E	127_H	0.999	0.43
161_I	164_P	0.997	0.43
225_W	443_L	0.994	0.43
332_G	362_L	0.988	0.42
122_V	424_V	0.987	0.42
332_G	427_F	0.984	0.42
202_L	455_T	0.983	0.42
329_Y	351_Y	0.979	0.42
11_M	227_R	0.979	0.42
202_L	466_W	0.975	0.41
316_K	438_R	0.975	0.41
383_D	386_G	0.972	0.41
427_F	438_R	0.969	0.41
20_K	318_A	0.968	0.41
116_P	318_A	0.964	0.41
89_V	94_R	0.963	0.41
123_L	321_H	0.960	0.40
14_M	56_C	0.960	0.40
428_E	433_T	0.959	0.40
201_N	439_K	0.958	0.40
332_G	360_S	0.951	0.40
3_L	226_E	0.950	0.40
10_M	49_T	0.948	0.40
180_W	316_K	0.948	0.40
184_D	195_I	0.942	0.39
3_L	8_L	0.942	0.39
318_A	438_R	0.941	0.39
105_E	108_P	0.940	0.39
362_L	408_T	0.937	0.39
302_L	311_L	0.936	0.39
302_L	413_L	0.933	0.39
180_W	318_A	0.932	0.39
122_V	316_K	0.932	0.39
175_S	341_N	0.929	0.38
408_T	414_L	0.925	0.38
27_V	61_R	0.919	0.38
122_V	362_L	0.918	0.38
345_V	456_A	0.917	0.38
118_S	127_H	0.916	0.38
113_D	122_V	0.911	0.37
224_L	415_A	0.911	0.37
203_H	465_W	0.911	0.37
24_W	413_L	0.906	0.37
197_S	211_Y	0.905	0.37
72_I	224_L	0.904	0.37
30_E	119_D	0.904	0.37
122_V	351_Y	0.902	0.37
123_L	127_H	0.900	0.37
15_N	75_V	0.899	0.37
56_C	114_W	0.894	0.36
86_D	134_V	0.892	0.36
13_L	48_L	0.890	0.36
215_E	225_W	0.888	0.36
26_K	116_P	0.888	0.36
116_P	122_V	0.886	0.36
184_D	312_Q	0.884	0.36
148_L	195_I	0.882	0.36
280_P	283_G	0.879	0.35
105_E	444_F	0.875	0.35
315_V	443_L	0.875	0.35
185_V	420_L	0.873	0.35
333_S	360_S	0.872	0.35
126_V	175_S	0.872	0.35
27_V	33_V	0.871	0.35
105_E	352_Y	0.867	0.35
122_V	127_H	0.866	0.35
138_T	167_E	0.865	0.35
334_W	416_F	0.865	0.35
20_K	115_H	0.864	0.35
232_L	336_V	0.863	0.34
231_D	309_R	0.863	0.34
333_S	381_Q	0.862	0.34
397_G	414_L	0.861	0.34
130_L	331_G	0.861	0.34
352_Y	440_I	0.854	0.34
49_T	62_D	0.851	0.34
318_A	351_Y	0.851	0.34
319_N	357_I	0.850	0.34
104_L	202_L	0.847	0.34
5_L	8_L	0.845	0.33
379_Y	386_G	0.844	0.33
129_S	332_G	0.834	0.33
10_M	14_M	0.833	0.33
131_F	432_P	0.831	0.33
453_I	458_V	0.831	0.33
126_V	202_L	0.825	0.32
115_H	440_I	0.823	0.32
381_Q	416_F	0.822	0.32
4_T	8_L	0.822	0.32
113_D	318_A	0.821	0.32
319_N	444_F	0.816	0.32
106_D	140_V	0.809	0.31
131_F	452_I	0.808	0.31
332_G	422_H	0.806	0.31
26_K	314_I	0.801	0.31
463_P	467_A	0.801	0.31
211_Y	215_E	0.801	0.31
183_C	197_S	0.799	0.31
323_T	427_F	0.798	0.31
446_V	454_S	0.797	0.31
116_P	381_Q	0.795	0.31
127_H	422_H	0.794	0.31
362_L	381_Q	0.794	0.31
59_E	63_K	0.793	0.30
28_F	61_R	0.792	0.30
115_H	416_F	0.792	0.30
48_L	81_G	0.791	0.30
57_L	178_F	0.791	0.30
204_P	446_V	0.788	0.30
332_G	444_F	0.787	0.30
35_K	332_G	0.786	0.30
427_F	436_G	0.785	0.30
386_G	390_V	0.784	0.30
184_D	454_S	0.783	0.30
48_L	391_Y	0.783	0.30
115_H	335_H	0.783	0.30
222_I	226_E	0.781	0.30
179_Q	347_T	0.780	0.30
325_E	349_L	0.778	0.30
77_D	80_S	0.778	0.30
56_C	61_R	0.776	0.30
451_R	454_S	0.775	0.29
337_E	444_F	0.772	0.29
187_V	226_E	0.772	0.29
308_G	355_E	0.772	0.29
113_D	314_I	0.771	0.29
300_V	305_D	0.770	0.29
135_Y	341_N	0.769	0.29
151_C	156_G	0.767	0.29
32_I	351_Y	0.767	0.29
225_W	368_V	0.766	0.29
39_E	130_L	0.765	0.29
141_L	195_I	0.763	0.29
151_C	158_G	0.762	0.29
356_N	436_G	0.762	0.29
122_V	332_G	0.761	0.29
132_P	348_A	0.761	0.29
218_I	315_V	0.760	0.29
17_I	199_I	0.759	0.29
318_A	360_S	0.757	0.29
332_G	335_H	0.756	0.28
424_V	444_F	0.754	0.28
122_V	326_K	0.750	0.28
63_K	67_F	0.749	0.28
383_D	455_T	0.748	0.28
249_D	254_P	0.746	0.28
228_V	383_D	0.746	0.28
57_L	224_L	0.746	0.28
321_H	439_K	0.743	0.28
183_C	443_L	0.741	0.28
118_S	416_F	0.741	0.28
180_W	418_N	0.738	0.28
221_A	413_L	0.738	0.28
57_L	283_G	0.738	0.28
335_H	424_V	0.738	0.28
49_T	61_R	0.736	0.27
6_R	139_R	0.735	0.27
124_D	129_S	0.733	0.27
48_L	56_C	0.733	0.27
35_K	434_K	0.733	0.27
416_F	424_V	0.733	0.27
52_M	105_E	0.732	0.27
127_H	337_E	0.731	0.27
133_L	202_L	0.731	0.27
18_T	56_C	0.729	0.27
416_F	444_F	0.728	0.27
184_D	425_S	0.727	0.27
360_S	438_R	0.726	0.27
26_K	332_G	0.725	0.27
388_E	394_E	0.725	0.27
127_H	442_A	0.724	0.27
197_S	202_L	0.719	0.27
318_A	440_I	0.718	0.26
427_F	437_H	0.718	0.26
180_W	362_L	0.716	0.26
20_K	316_K	0.716	0.26
187_V	307_R	0.715	0.26
85_S	454_S	0.714	0.26
7_E	10_M	0.713	0.26
351_Y	360_S	0.711	0.26
194_K	215_E	0.707	0.26
146_V	217_L	0.705	0.26
228_V	386_G	0.704	0.26
35_K	381_Q	0.703	0.26
76_L	187_V	0.702	0.26
248_E	255_P	0.700	0.26
204_P	465_W	0.699	0.26
290_E	430_A	0.699	0.26
353_D	358_T	0.698	0.25
436_G	448_P	0.698	0.25
208_R	212_S	0.698	0.25
129_S	329_Y	0.697	0.25
333_S	421_Q	0.695	0.25
115_H	337_E	0.695	0.25
58_A	306_F	0.694	0.25
225_W	310_G	0.693	0.25
118_S	314_I	0.693	0.25
252_Y	255_P	0.692	0.25
116_P	335_H	0.692	0.25
426_P	432_P	0.692	0.25
249_D	252_Y	0.687	0.25
351_Y	444_F	0.687	0.25
113_D	333_S	0.687	0.25
222_I	229_L	0.686	0.25
318_A	416_F	0.686	0.25
357_I	444_F	0.686	0.25
406_V	414_L	0.686	0.25
124_D	318_A	0.685	0.25
177_K	355_E	0.684	0.25
224_L	348_A	0.684	0.25
35_K	422_H	0.683	0.25
381_Q	424_V	0.682	0.25
187_V	311_L	0.682	0.25
264_D	273_N	0.682	0.25
350_Y	364_F	0.681	0.25
16_A	138_T	0.680	0.25
41_L	53_V	0.679	0.25
40_A	235_R	0.679	0.25
311_L	449_H	0.679	0.25
48_L	53_V	0.678	0.24
73_V	84_K	0.677	0.24
337_E	365_R	0.677	0.24
85_S	179_Q	0.677	0.24
112_K	123_L	0.676	0.24
132_P	400_N	0.675	0.24
431_D	458_V	0.674	0.24
20_K	337_E	0.671	0.24
73_V	77_D	0.671	0.24
258_E	261_E	0.670	0.24
408_T	415_A	0.669	0.24
75_V	195_I	0.668	0.24
348_A	456_A	0.668	0.24
362_L	438_R	0.668	0.24
113_D	130_L	0.667	0.24
226_E	300_V	0.667	0.24
20_K	349_L	0.666	0.24
126_V	315_V	0.666	0.24
19_D	63_K	0.665	0.24
11_M	185_V	0.661	0.24
218_I	221_A	0.661	0.24
21_P	112_K	0.660	0.24
62_D	285_F	0.658	0.24
362_L	416_F	0.658	0.24
225_W	406_V	0.658	0.24
317_L	439_K	0.657	0.23
125_L	202_L	0.656	0.23
381_Q	422_H	0.655	0.23
113_D	362_L	0.655	0.23
107_V	329_Y	0.654	0.23
115_H	362_L	0.652	0.23
401_Q	445_L	0.652	0.23
135_Y	241_R	0.652	0.23
76_L	132_P	0.649	0.23
332_G	416_F	0.649	0.23
255_P	259_D	0.648	0.23
16_A	53_V	0.648	0.23
124_D	180_W	0.648	0.23
359_E	458_V	0.647	0.23
259_D	268_E	0.646	0.23
316_K	427_F	0.643	0.23
115_H	180_W	0.643	0.23
59_E	241_R	0.643	0.23
343_H	391_Y	0.640	0.23
248_E	251_E	0.639	0.23
56_C	63_K	0.638	0.23
132_P	221_A	0.637	0.23
108_P	114_W	0.637	0.23
16_A	452_I	0.636	0.23
34_A	326_K	0.635	0.22
33_V	57_L	0.635	0.22
254_P	257_D	0.635	0.22
124_D	335_H	0.635	0.22
26_K	129_S	0.629	0.22
53_V	63_K	0.628	0.22
408_T	412_R	0.626	0.22
127_H	316_K	0.625	0.22
318_A	362_L	0.625	0.22
14_M	57_L	0.624	0.22
220_R	224_L	0.624	0.22
246_D	249_D	0.623	0.22
73_V	185_V	0.622	0.22
360_S	381_Q	0.622	0.22
7_E	179_Q	0.621	0.22
152_L	205_E	0.621	0.22
39_E	424_V	0.621	0.22
35_K	316_K	0.619	0.22
118_S	122_V	0.616	0.22
332_G	440_I	0.615	0.22
26_K	122_V	0.615	0.22
174_F	187_V	0.614	0.22
147_G	190_D	0.613	0.21
20_K	129_S	0.612	0.21
343_H	414_L	0.612	0.21
312_Q	401_Q	0.611	0.21
113_D	127_H	0.610	0.21
138_T	294_Y	0.609	0.21
24_W	68_E	0.609	0.21
222_I	310_G	0.609	0.21
448_P	461_Q	0.608	0.21
217_L	221_A	0.605	0.21
51_A	54_D	0.605	0.21
254_P	268_E	0.604	0.21
256_E	259_D	0.604	0.21
74_S	222_I	0.603	0.21
455_T	461_Q	0.602	0.21
146_V	152_L	0.600	0.21
115_H	313_V	0.600	0.21
5_L	9_A	0.597	0.21
318_A	408_T	0.597	0.21
323_T	327_P	0.595	0.21
199_I	352_Y	0.594	0.21
111_E	405_S	0.593	0.21
139_R	143_D	0.593	0.21
218_I	415_A	0.593	0.21
116_P	442_A	0.592	0.21
75_V	183_C	0.592	0.21
68_E	214_I	0.589	0.20
248_E	253_E	0.588	0.20
96_R	325_E	0.586	0.20
118_S	124_D	0.586	0.20
320_I	326_K	0.585	0.20
177_K	383_D	0.584	0.20
124_D	357_I	0.584	0.20
362_L	422_H	0.583	0.20
331_G	337_E	0.583	0.20
129_S	320_I	0.582	0.20
317_L	440_I	0.582	0.20
108_P	439_K	0.582	0.20
116_P	416_F	0.582	0.20
334_W	422_H	0.581	0.20
325_E	384_D	0.580	0.20
115_H	344_I	0.577	0.20
211_Y	346_A	0.577	0.20
273_N	276_P	0.577	0.20
18_T	225_W	0.576	0.20
351_Y	440_I	0.576	0.20
103_P	213_V	0.575	0.20
191_G	432_P	0.575	0.20
269_E	299_P	0.574	0.20
115_H	124_D	0.573	0.20
306_F	309_R	0.573	0.20
26_K	381_Q	0.570	0.20
229_L	392_G	0.570	0.20
56_C	194_K	0.569	0.20
359_E	430_A	0.569	0.20
264_D	391_Y	0.568	0.20
196_T	310_G	0.568	0.20
216_K	219_A	0.566	0.20
166_D	169_T	0.565	0.19
90_P	93_L	0.565	0.19
92_E	328_E	0.564	0.19
422_H	444_F	0.563	0.19
26_K	113_D	0.563	0.19
134_V	137_R	0.560	0.19
386_G	460_P	0.559	0.19
121_Q	222_I	0.559	0.19
346_A	465_W	0.558	0.19
134_V	168_E	0.557	0.19
342_E	352_Y	0.557	0.19
286_F	289_P	0.556	0.19
337_E	408_T	0.556	0.19
10_M	18_T	0.556	0.19
322_L	332_G	0.556	0.19
270_W	274_R	0.555	0.19
284_E	462_Q	0.555	0.19
124_D	438_R	0.554	0.19
351_Y	442_A	0.553	0.19
107_V	439_K	0.551	0.19
360_S	427_F	0.550	0.19
196_T	343_H	0.550	0.19
58_A	62_D	0.550	0.19
184_D	196_T	0.549	0.19
403_L	419_I	0.549	0.19
26_K	180_W	0.549	0.19
109_E	222_I	0.547	0.19
30_E	93_L	0.547	0.19
107_V	130_L	0.547	0.19
255_P	258_E	0.546	0.19
122_V	381_Q	0.544	0.19
221_A	225_W	0.544	0.19
186_E	222_I	0.544	0.19
362_L	424_V	0.543	0.19
24_W	28_F	0.543	0.19
314_I	342_E	0.543	0.19
114_W	415_A	0.542	0.19
32_I	381_Q	0.540	0.18
214_I	315_V	0.540	0.18
113_D	381_Q	0.537	0.18
4_T	7_E	0.536	0.18
22_D	309_R	0.535	0.18
63_K	453_I	0.533	0.18
128_P	180_W	0.533	0.18
121_Q	331_G	0.533	0.18
137_R	443_L	0.533	0.18
63_K	75_V	0.533	0.18
339_M	386_G	0.532	0.18
132_P	178_F	0.532	0.18
116_P	438_R	0.532	0.18
219_A	224_L	0.532	0.18
96_R	209_E	0.532	0.18
82_V	410_E	0.531	0.18
53_V	57_L	0.531	0.18
246_D	251_E	0.531	0.18
89_V	217_L	0.530	0.18
35_K	351_Y	0.529	0.18
27_V	82_V	0.528	0.18
210_L	331_G	0.528	0.18
452_I	457_N	0.527	0.18
172_Y	385_E	0.527	0.18
180_W	351_Y	0.527	0.18
165_P	168_E	0.526	0.18
192_G	432_P	0.525	0.18
256_E	260_D	0.524	0.18
55_Y	343_H	0.524	0.18
333_S	427_F	0.524	0.18
329_Y	333_S	0.524	0.18
255_P	260_D	0.524	0.18
26_K	438_R	0.523	0.18
82_V	414_L	0.523	0.18
362_L	444_F	0.523	0.18
226_E	343_H	0.523	0.18
148_L	423_R	0.521	0.18
113_D	337_E	0.520	0.18
349_L	424_V	0.519	0.18
140_V	458_V	0.519	0.18
37_R	53_V	0.518	0.18
129_S	316_K	0.518	0.18
304_E	313_V	0.518	0.18
139_R	158_G	0.516	0.18
191_G	413_L	0.516	0.18
394_E	397_G	0.515	0.17
17_I	414_L	0.515	0.17
124_D	362_L	0.515	0.17
256_E	261_E	0.515	0.17
306_F	310_G	0.514	0.17
131_F	344_I	0.514	0.17
105_E	213_V	0.513	0.17
449_H	452_I	0.513	0.17
122_V	180_W	0.512	0.17
139_R	156_G	0.512	0.17
112_K	439_K	0.512	0.17
226_E	303_R	0.512	0.17
224_L	343_H	0.511	0.17
200_N	344_I	0.511	0.17
101_V	107_V	0.510	0.17
234_L	238_R	0.510	0.17
95_S	99_A	0.510	0.17
424_V	427_F	0.510	0.17
137_R	442_A	0.510	0.17
202_L	214_I	0.510	0.17
76_L	178_F	0.510	0.17
243_E	275_R	0.510	0.17
54_D	433_T	0.508	0.17
123_L	317_L	0.507	0.17
134_V	242_I	0.506	0.17
32_I	320_I	0.506	0.17
143_D	187_V	0.506	0.17
28_F	63_K	0.505	0.17
32_I	329_Y	0.503	0.17
222_I	398_P	0.502	0.17
116_P	424_V	0.502	0.17
335_H	444_F	0.502	0.17
7_E	11_M	0.501	0.17
325_E	458_V	0.501	0.17
116_P	337_E	0.501	0.17
292_P	295_D	0.501	0.17
353_D	359_E	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2rg4A	4	0.4392	12.6	0.984	Contact Map
3itqA	2	0.3518	11.2	0.984	Contact Map
4ajyV	1	0.1151	9.7	0.985	Contact Map
4wxxA	1	0.1279	8.4	0.985	Contact Map
3hzsA	3	0.1237	7.2	0.986	Contact Map
3vmtA	1	0.1258	6.3	0.986	Contact Map
4xlgB	1	0.1386	6	0.986	Contact Map
4wqoA	1	0.1151	5.8	0.986	Contact Map
3g7uA	1	0.113	5.7	0.986	Contact Map
3i5pA	1	0.1684	5.4	0.987	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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