GREMLIN Database
DUF4244 - Protein of unknown function (DUF4244)
PFAM: PF14029 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (50)
Sequences: 3219 (1779)
Seq/√Len: 251.5
META: 0.797

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_M21_G3.7991.00
14_T21_G3.4481.00
34_K37_T2.0151.00
42_R46_T1.8691.00
40_A46_T1.7761.00
16_A26_A1.7271.00
43_G47_G1.6531.00
33_Y37_T1.5801.00
39_D42_R1.5531.00
22_T30_G1.5411.00
6_R9_D1.4911.00
48_L53_L1.4621.00
28_F36_L1.4521.00
46_T50_R1.4371.00
16_A22_T1.3721.00
7_L11_A1.2691.00
38_S42_R1.2401.00
27_A33_Y1.2061.00
16_A20_V1.2021.00
5_R9_D1.1911.00
40_A50_R1.1911.00
41_V49_I1.1241.00
43_G46_T1.1191.00
47_G51_R1.1101.00
14_T22_T1.0641.00
30_G34_K1.0341.00
13_M25_A1.0121.00
24_A36_L1.0071.00
27_A36_L0.9611.00
4_R8_R0.9291.00
24_A32_L0.9261.00
4_R7_L0.9211.00
5_R8_R0.9081.00
24_A33_Y0.8811.00
23_L33_Y0.8701.00
24_A28_F0.8460.99
20_V26_A0.8420.99
40_A44_L0.8040.99
40_A43_G0.8010.99
44_L47_G0.7990.99
31_L44_L0.7790.99
29_A34_K0.7770.99
26_A30_G0.7540.99
28_F41_V0.7400.98
7_L43_G0.7170.98
25_A32_L0.7170.98
31_L34_K0.7150.98
34_K38_S0.7030.98
13_M16_A0.6970.98
39_D43_G0.6960.98
16_A19_A0.6660.97
25_A29_A0.6560.97
30_G33_Y0.6510.96
6_R11_A0.6460.96
13_M22_T0.6400.96
22_T26_A0.6090.95
19_A26_A0.5930.94
29_A32_L0.5840.94
23_L26_A0.5810.93
29_A41_V0.5810.93
35_V41_V0.5740.93
47_G50_R0.5690.93
34_K42_R0.5650.93
32_L38_S0.5610.92
15_T32_L0.5510.92
44_L48_L0.5460.91
27_A31_L0.5430.91
10_D31_L0.5360.90
8_R11_A0.5360.90
15_T18_Y0.5310.90
7_L47_G0.5270.90
19_A27_A0.5090.88
20_V33_Y0.5090.88
12_G17_E0.5090.88
43_G50_R0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ytpD 1 0.7778 3.9 0.868 Contact Map
1xc0A 1 0.5 3.4 0.872 Contact Map
1elkA 1 0.4074 3.2 0.874 Contact Map
3ni7A 2 0.9259 3.1 0.875 Contact Map
2yicA 2 0.9444 3 0.875 Contact Map
2xt6A 2 0.9444 2.7 0.878 Contact Map
4ysxD 1 0.8704 2.1 0.886 Contact Map
4kxvA 2 0.8889 2 0.887 Contact Map
4puiA 1 0.3333 2 0.887 Contact Map
2x3nA 1 0.6667 2 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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