GREMLIN Database
DUF4241 - Protein of unknown function (DUF4241)
PFAM: PF14025 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 188 (178)
Sequences: 1585 (1306)
Seq/√Len: 97.9
META: 0.734

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_P34_Y4.3191.00
87_Y94_G4.1981.00
37_E55_R3.2911.00
63_P184_V3.1931.00
54_A162_F3.1911.00
90_D168_D2.9711.00
87_Y188_T2.9541.00
27_R177_Y2.8101.00
9_I186_L2.7581.00
6_S100_E2.7101.00
178_D182_E2.6821.00
27_R175_W2.6551.00
38_L54_A2.4861.00
61_E178_D2.3551.00
11_A25_F2.3381.00
3_V33_R2.3101.00
29_V58_F2.2841.00
39_A55_R2.2761.00
86_G170_F2.1291.00
173_S188_T2.1131.00
34_Y58_F2.1121.00
8_R28_T2.1121.00
167_G171_Y2.0481.00
4_L29_V1.9611.00
29_V34_Y1.9371.00
175_W186_L1.8751.00
50_R166_W1.8301.00
5_P100_E1.8131.00
88_G168_D1.7941.00
177_Y183_V1.7501.00
149_N160_V1.7471.00
54_A96_F1.7011.00
173_S186_L1.6921.00
37_E57_R1.6451.00
43_V48_G1.5871.00
65_R177_Y1.5541.00
9_I56_L1.5331.00
84_F172_P1.5301.00
8_R99_A1.5171.00
59_S182_E1.4961.00
43_V166_W1.4821.00
69_A175_W1.4231.00
59_S184_V1.4171.00
2_L56_L1.4030.99
129_L132_E1.4000.99
30_P34_Y1.3960.99
127_A131_E1.3440.99
48_G166_W1.3280.99
38_L51_V1.3230.99
4_L9_I1.3150.99
94_G162_F1.3040.99
89_V171_Y1.3030.99
125_L129_L1.2910.99
13_D91_A1.2870.99
116_N119_G1.2790.99
27_R67_E1.2770.99
97_M102_A1.2120.99
92_G167_G1.2030.98
92_G164_S1.1990.98
123_D127_A1.1970.98
4_L31_P1.1930.98
94_G188_T1.1880.98
121_I125_L1.1850.98
80_G83_E1.1840.98
101_A157_A1.1810.98
70_L74_Q1.1630.98
178_D184_V1.1610.98
67_E177_Y1.1420.98
71_T74_Q1.1350.98
68_L79_L1.1140.97
95_C162_F1.1060.97
40_V51_V1.1060.97
79_L83_E1.0810.97
79_L85_F1.0760.97
66_W176_G1.0700.97
89_V168_D1.0630.97
149_N152_L1.0580.96
57_R60_D1.0530.96
176_G187_V1.0470.96
127_A130_F1.0290.96
131_E134_Y1.0120.95
87_Y173_S1.0100.95
89_V167_G1.0050.95
27_R183_V0.9940.95
75_D78_E0.9770.95
13_D89_V0.9730.94
176_G185_C0.9720.94
122_Y126_F0.9700.94
70_L76_L0.9620.94
165_G171_Y0.9530.94
157_A160_V0.9490.94
96_F188_T0.9460.94
66_W187_V0.9440.93
58_F186_L0.9380.93
126_F129_L0.9370.93
16_V91_A0.9210.93
165_G169_G0.9140.92
56_L96_F0.9080.92
48_G163_S0.9040.92
7_G98_D0.8950.91
39_A53_A0.8920.91
26_T70_L0.8860.91
164_S168_D0.8820.91
111_E115_E0.8810.91
74_Q85_F0.8710.90
175_W183_V0.8550.90
43_V47_D0.8420.89
120_N124_D0.8380.89
55_R185_C0.8370.89
130_F133_S0.8350.88
50_R163_S0.8310.88
94_G173_S0.8300.88
2_L36_V0.8270.88
6_S99_A0.8230.88
149_N158_N0.8220.88
42_D49_E0.8200.87
63_P185_C0.8190.87
64_V179_A0.8180.87
84_F170_F0.8110.87
71_T83_E0.8090.87
6_S98_D0.8070.87
92_G168_D0.8070.87
11_A173_S0.8000.86
61_E184_V0.7990.86
12_C97_M0.7960.86
156_G159_V0.7920.86
78_E85_F0.7920.86
90_D164_S0.7900.85
168_D171_Y0.7830.85
54_A94_G0.7820.85
120_N123_D0.7810.85
20_P23_E0.7790.85
5_P31_P0.7660.84
73_G79_L0.7590.83
96_F162_F0.7590.83
25_F173_S0.7560.83
65_R181_G0.7550.83
63_P176_G0.7480.82
12_C24_P0.7470.82
130_F161_A0.7460.82
14_P98_D0.7380.81
90_D167_G0.7350.81
131_E135_K0.7330.81
9_I29_V0.7310.81
14_P32_G0.7290.81
43_V49_E0.7200.80
3_V158_N0.7180.80
11_A96_F0.7180.80
133_S148_L0.7160.79
89_V164_S0.7090.79
177_Y181_G0.6980.78
2_L95_C0.6980.78
27_R186_L0.6970.78
29_V175_W0.6970.78
101_A104_A0.6880.77
50_R167_G0.6860.76
70_L73_G0.6850.76
87_Y96_F0.6840.76
3_V157_A0.6780.76
10_V22_A0.6780.76
60_D110_E0.6770.75
103_R182_E0.6750.75
144_G148_L0.6740.75
129_L134_Y0.6720.75
11_A188_T0.6640.74
121_I124_D0.6600.74
123_D126_F0.6580.73
74_Q86_G0.6550.73
26_T72_P0.6520.73
29_V53_A0.6510.73
105_L160_V0.6420.72
122_Y130_F0.6400.71
50_R88_G0.6390.71
117_P120_N0.6380.71
175_W185_C0.6370.71
40_V49_E0.6370.71
50_R168_D0.6360.71
151_P155_T0.6320.70
11_A87_Y0.6320.70
116_N120_N0.6280.70
30_P182_E0.6260.70
79_L82_G0.6240.69
35_P66_W0.6160.68
60_D78_E0.6150.68
164_S171_Y0.6130.68
121_I126_F0.6120.68
155_T160_V0.6110.68
95_C159_V0.6090.68
117_P122_Y0.6080.67
122_Y125_L0.6080.67
54_A95_C0.6060.67
26_T132_E0.6040.67
95_C98_D0.6040.67
102_A106_D0.6020.67
39_A63_P0.6010.67
34_Y56_L0.5970.66
91_A168_D0.5960.66
4_L98_D0.5940.66
164_S167_G0.5920.65
143_D146_D0.5920.65
128_D132_E0.5890.65
119_G124_D0.5870.65
105_L159_V0.5860.65
147_W152_L0.5840.64
95_C164_S0.5830.64
38_L162_F0.5820.64
36_V158_N0.5820.64
125_L150_W0.5820.64
2_L158_N0.5800.64
41_A164_S0.5800.64
4_L101_A0.5770.63
99_A103_R0.5770.63
79_L84_F0.5750.63
36_V95_C0.5750.63
16_V22_A0.5740.63
49_E163_S0.5730.63
45_D48_G0.5720.63
86_G173_S0.5710.63
12_C93_T0.5680.62
89_V169_G0.5680.62
21_D25_F0.5680.62
16_V88_G0.5660.62
48_G91_A0.5640.62
13_D167_G0.5570.61
28_T34_Y0.5560.61
68_L84_F0.5560.61
150_W156_G0.5530.60
183_V186_L0.5520.60
40_V50_R0.5520.60
10_V24_P0.5490.60
29_V186_L0.5460.59
2_L34_Y0.5440.59
101_A159_V0.5420.59
75_D85_F0.5390.58
132_E135_K0.5380.58
123_D128_D0.5360.58
88_G170_F0.5340.58
56_L156_G0.5330.57
97_M101_A0.5320.57
82_G85_F0.5310.57
51_V145_G0.5280.57
34_Y175_W0.5250.56
12_C22_A0.5230.56
41_A52_A0.5230.56
12_C91_A0.5210.56
11_A172_P0.5150.55
55_R187_V0.5150.55
123_D131_E0.5150.55
39_A54_A0.5150.55
151_P156_G0.5120.54
70_L85_F0.5100.54
2_L66_W0.5100.54
53_A187_V0.5090.54
61_E179_A0.5090.54
36_V160_V0.5080.54
13_D165_G0.5080.54
15_L93_T0.5070.54
68_L86_G0.5070.54
74_Q79_L0.5060.54
120_N127_A0.5060.54
4_L34_Y0.5060.54
66_W162_F0.5060.54
71_T75_D0.5030.53
142_R146_D0.5020.53
124_D130_F0.5010.53
74_Q170_F0.5000.53
43_V50_R0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iu4A 2 0.3777 39 0.921 Contact Map
3ct4A 3 0.383 30.5 0.925 Contact Map
1un8A 2 0.3936 19.4 0.932 Contact Map
4pj2A 1 0.6223 18 0.933 Contact Map
1oi2A 2 0.3404 9.8 0.94 Contact Map
2ag4A 1 0.3032 5.5 0.947 Contact Map
3ottA 2 0.3723 5 0.948 Contact Map
3bwuD 1 0.5691 4.7 0.949 Contact Map
4a2lA 4 0.3298 4.3 0.949 Contact Map
3mtxA 1 0.3138 3.8 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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