GREMLIN Database
DUF4240 - Protein of unknown function (DUF4240)
PFAM: PF14024 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 128 (124)
Sequences: 3903 (3073)
Seq/√Len: 276.0
META: 0.831

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_R91_E3.6841.00
56_T59_L2.6401.00
13_A24_Q2.4491.00
50_L53_R2.3431.00
81_W85_Q2.3121.00
12_R31_R2.2571.00
44_D48_D2.2401.00
116_E120_Y2.1491.00
46_I50_L2.0591.00
73_D77_Y2.0281.00
84_A118_L2.0131.00
3_E50_L1.9561.00
40_I125_A1.9481.00
63_A70_C1.8781.00
54_A82_L1.8081.00
80_C119_L1.7611.00
4_D87_R1.7101.00
55_Y79_R1.7001.00
42_A46_I1.6761.00
51_L80_C1.6421.00
47_F80_C1.6361.00
93_A99_S1.6211.00
57_W61_A1.6131.00
35_L39_E1.6121.00
36_S39_E1.5861.00
31_R34_K1.5711.00
60_W70_C1.5431.00
29_V33_A1.5371.00
46_I49_E1.5261.00
50_L90_Y1.5161.00
29_V125_A1.4771.00
75_F79_R1.4051.00
51_L76_L1.3841.00
3_E53_R1.3791.00
64_Y69_G1.3741.00
54_A59_L1.3641.00
54_A90_Y1.3501.00
2_D5_E1.3451.00
49_E53_R1.3441.00
29_V124_E1.3341.00
14_R24_Q1.2691.00
27_A31_R1.2481.00
50_L91_E1.2331.00
5_E35_L1.2101.00
121_V125_A1.1981.00
21_P115_F1.1941.00
11_E14_R1.1861.00
88_E92_A1.1741.00
3_E46_I1.1661.00
77_Y114_E1.1361.00
62_A98_D1.1271.00
89_V100_L1.1111.00
9_L28_L1.1061.00
53_R90_Y1.0851.00
54_A94_L1.0801.00
32_L40_I1.0681.00
51_L83_I1.0621.00
77_Y116_E1.0601.00
8_E12_R1.0571.00
44_D122_A1.0571.00
98_D101_A1.0361.00
39_E42_A1.0311.00
67_N74_G1.0131.00
92_A99_S1.0111.00
84_A115_F1.0001.00
96_D99_S0.9931.00
25_A115_F0.9881.00
33_A125_A0.9841.00
37_P40_I0.9811.00
28_L121_V0.9771.00
28_L43_F0.9761.00
55_Y60_W0.9741.00
85_Q89_V0.9651.00
20_D23_E0.9631.00
62_A100_L0.9531.00
5_E8_E0.9501.00
10_I118_L0.9331.00
59_L82_L0.9261.00
89_V103_L0.9251.00
51_L79_R0.9201.00
47_F83_I0.9141.00
9_L31_R0.8941.00
16_A27_A0.8891.00
72_D77_Y0.8841.00
5_E39_E0.8841.00
54_A79_R0.8811.00
67_N113_L0.8751.00
74_G114_E0.8651.00
76_L80_C0.8641.00
80_C118_L0.8591.00
64_Y67_N0.8491.00
67_N114_E0.8491.00
60_W75_F0.8391.00
6_F47_F0.8381.00
115_F119_L0.8351.00
2_D46_I0.8341.00
89_V93_A0.8291.00
14_R85_Q0.8270.99
76_L119_L0.8250.99
66_I93_A0.8220.99
100_L103_L0.8190.99
71_S77_Y0.8190.99
30_E34_K0.8170.99
81_W113_L0.8090.99
76_L79_R0.7940.99
60_W63_A0.7910.99
65_I98_D0.7900.99
53_R91_E0.7830.99
104_P107_E0.7700.99
13_A28_L0.7670.99
37_P41_V0.7660.99
66_I113_L0.7550.99
60_W69_G0.7520.99
24_Q84_A0.7470.99
13_A27_A0.7460.99
77_Y80_C0.7400.99
83_I90_Y0.7330.99
115_F118_L0.7270.99
55_Y76_L0.7220.99
31_R35_L0.7190.99
25_A29_V0.7070.98
92_A102_D0.7050.98
37_P126_Y0.6960.98
3_E49_E0.6810.98
26_E29_V0.6790.98
117_E120_Y0.6740.98
78_F81_W0.6740.98
21_P25_A0.6730.98
40_I122_A0.6730.98
53_R94_L0.6720.98
25_A121_V0.6700.98
82_L93_A0.6690.98
71_S74_G0.6670.98
29_V121_V0.6640.98
60_W64_Y0.6600.98
44_D47_F0.6580.98
59_L62_A0.6560.97
124_E127_E0.6540.97
16_A31_R0.6340.97
6_F46_I0.6340.97
73_D116_E0.6280.97
14_R17_A0.6200.96
77_Y120_Y0.6180.96
1_M32_L0.6120.96
24_Q85_Q0.6120.96
3_E91_E0.6110.96
92_A103_L0.6110.96
61_A65_I0.6090.96
82_L100_L0.6040.96
11_E87_R0.6020.96
78_F100_L0.6010.96
18_G23_E0.5970.96
63_A69_G0.5960.96
36_S40_I0.5940.95
61_A68_G0.5920.95
120_Y124_E0.5870.95
21_P24_Q0.5870.95
4_D8_E0.5860.95
17_A27_A0.5850.95
45_R49_E0.5840.95
117_E124_E0.5830.95
42_A45_R0.5790.95
51_L54_A0.5730.95
104_P113_L0.5660.94
63_A74_G0.5630.94
106_V112_D0.5620.94
52_A55_Y0.5610.94
56_T94_L0.5610.94
47_F119_L0.5610.94
59_L93_A0.5580.94
38_E42_A0.5520.93
77_Y119_L0.5380.92
91_E95_A0.5370.92
5_E9_L0.5350.92
24_Q81_W0.5230.91
59_L97_P0.5200.91
64_Y70_C0.5180.91
11_E15_A0.5130.91
92_A95_A0.5100.90
85_Q103_L0.5090.90
15_A95_A0.5060.90
62_A97_P0.5050.90
54_A76_L0.5040.90
69_G72_D0.5010.90
78_F98_D0.5000.89
120_Y123_S0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pueE 1 0.5391 17.2 0.896 Contact Map
3m8jA 2 0.5547 11.5 0.904 Contact Map
1awcA 1 0.5078 10 0.907 Contact Map
4co8A 2 0.5391 8.3 0.91 Contact Map
3nehA 1 0.9297 8 0.911 Contact Map
2i5gA 2 0.9531 6.3 0.915 Contact Map
1hbxG 1 0.5312 5.7 0.917 Contact Map
2l08A 1 0.5312 5 0.919 Contact Map
1yo5C 1 0.5234 4.8 0.919 Contact Map
1bc8C 1 0.5391 4.8 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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