GREMLIN Database
DUF4236 - Protein of unknown function (DUF4236)
PFAM: PF14020 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 55 (54)
Sequences: 7061 (4637)
Seq/√Len: 631.0
META: 0.925

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_S14_R3.3221.00
25_S32_R2.4351.00
42_Y55_R2.1981.00
28_V32_R2.0781.00
33_V41_T1.9771.00
36_G40_G1.9461.00
2_R53_S1.8781.00
23_S34_T1.7901.00
47_I50_T1.7461.00
15_L24_L1.5551.00
1_F54_Y1.5511.00
32_R44_T1.5411.00
7_I17_L1.5291.00
8_K14_R1.4771.00
37_P40_G1.4591.00
18_S21_G1.4441.00
17_L22_V1.3581.00
14_R32_R1.3251.00
33_V43_V1.3221.00
10_G13_V1.2741.00
35_V41_T1.2731.00
44_T55_R1.2351.00
13_V26_V1.1641.00
15_L22_V1.1581.00
4_R53_S1.1511.00
31_A45_V1.1451.00
45_V54_Y1.0941.00
28_V31_A1.0091.00
3_F52_L0.9941.00
8_K11_P0.9631.00
20_S38_R0.9601.00
4_R14_R0.9321.00
4_R18_S0.9061.00
46_G50_T0.8961.00
9_L13_V0.8921.00
27_G32_R0.8861.00
30_G46_G0.8451.00
34_T42_Y0.8401.00
27_G30_G0.8301.00
16_N23_S0.8201.00
23_S37_P0.8171.00
1_F19_K0.8101.00
46_G49_G0.8021.00
43_V54_Y0.7961.00
21_G37_P0.7841.00
11_P26_V0.7491.00
1_F52_L0.7451.00
44_T53_S0.7351.00
37_P41_T0.7281.00
2_R44_T0.7001.00
31_A43_V0.6891.00
25_S34_T0.6791.00
44_T54_Y0.6681.00
41_T45_V0.6601.00
29_R46_G0.6561.00
8_K12_G0.6461.00
35_V40_G0.6431.00
31_A35_V0.6311.00
34_T44_T0.6301.00
7_I22_V0.6241.00
22_V26_V0.6231.00
9_L12_G0.6201.00
16_N25_S0.6061.00
9_L15_L0.6041.00
23_S36_G0.5991.00
6_S16_N0.5981.00
46_G53_S0.5711.00
13_V24_L0.5591.00
7_I12_G0.5541.00
17_L30_G0.5511.00
44_T47_I0.5471.00
12_G26_V0.5380.99
22_V37_P0.5310.99
16_N34_T0.5260.99
25_S44_T0.5250.99
21_G36_G0.5250.99
3_F44_T0.5170.99
4_R34_T0.5110.99
3_F7_I0.5070.99
25_S53_S0.5010.99
5_K29_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2digA 1 0.5636 2.2 0.881 Contact Map
4xc5A 3 0.7455 2.2 0.881 Contact Map
1whsA 2 0.9818 1.7 0.889 Contact Map
4ci9A 2 0.9273 1.6 0.89 Contact Map
2wjrA 1 0.8182 1.5 0.891 Contact Map
4fqeA 1 0.8182 1.3 0.895 Contact Map
4n1iA 1 0.2 1.3 0.896 Contact Map
1dbdA 2 0.9273 1.3 0.896 Contact Map
4bvwA 1 0.2 1.3 0.896 Contact Map
1c7sA 2 0.8727 1.3 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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