GREMLIN Database
DUF4234 - Domain of unknown function (DUF4234)
PFAM: PF14018 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 70 (66)
Sequences: 7826 (5503)
Seq/√Len: 677.4
META: 0.941

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_Y24_K3.4901.00
10_S18_G3.0551.00
5_L9_L2.4551.00
9_L12_V2.3971.00
27_E31_R2.3281.00
3_I6_V1.8801.00
3_I7_I1.8721.00
51_L54_G1.8471.00
52_T56_V1.8461.00
5_L8_L1.8241.00
6_V10_S1.8181.00
4_G8_L1.8061.00
53_L56_V1.7791.00
2_S5_L1.7151.00
39_G44_V1.6741.00
8_L12_V1.5081.00
41_G44_V1.4101.00
40_S43_L1.3611.00
51_L56_V1.3311.00
16_I20_Y1.3211.00
62_Y65_G1.3071.00
29_L33_S1.2581.00
40_S44_V1.1791.00
24_K27_E1.1771.00
17_Y20_Y1.1431.00
6_V17_Y1.1411.00
24_K28_E1.0941.00
58_I62_Y1.0851.00
62_Y66_K1.0721.00
22_Y26_N1.0671.00
36_G39_G1.0541.00
55_I59_V1.0451.00
54_G57_P1.0381.00
61_F65_G1.0201.00
37_P41_G0.9931.00
63_K67_R0.9841.00
23_Y27_E0.9821.00
39_G43_L0.9501.00
36_G41_G0.9401.00
7_I10_S0.8961.00
52_T55_I0.8931.00
56_V60_W0.8771.00
4_G7_I0.8661.00
65_G68_L0.8661.00
25_T64_T0.8601.00
14_L53_L0.8491.00
59_V63_K0.8321.00
39_G42_G0.8251.00
60_W67_R0.8121.00
19_L23_Y0.8081.00
48_L52_T0.8041.00
22_Y60_W0.8041.00
29_L64_T0.7721.00
23_Y46_L0.7501.00
9_L13_T0.7461.00
49_G52_T0.7301.00
36_G40_S0.7291.00
48_L51_L0.7281.00
37_P42_G0.7171.00
38_G41_G0.7011.00
38_G44_V0.6951.00
57_P61_F0.6941.00
21_W25_T0.6931.00
19_L22_Y0.6881.00
26_N30_K0.6851.00
17_Y24_K0.6791.00
31_R34_G0.6771.00
6_V25_T0.6661.00
46_L50_L0.6641.00
53_L57_P0.6501.00
15_G19_L0.6381.00
60_W63_K0.6191.00
46_L49_G0.6041.00
5_L17_Y0.6031.00
25_T28_E0.6031.00
38_G42_G0.5881.00
8_L16_I0.5861.00
2_S6_V0.5841.00
60_W65_G0.5781.00
37_P40_S0.5751.00
5_L10_S0.5721.00
64_T68_L0.5611.00
22_Y64_T0.5601.00
25_T29_L0.5531.00
26_N64_T0.5521.00
28_E32_Y0.5471.00
50_L54_G0.5421.00
61_F64_T0.5411.00
30_K38_G0.5391.00
36_G42_G0.5351.00
6_V21_W0.5331.00
26_N33_S0.5321.00
63_K66_K0.5190.99
30_K39_G0.5160.99
48_L53_L0.5090.99
30_K34_G0.5070.99
32_Y35_D0.5030.99
64_T67_R0.5020.99
18_G22_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.5714 11.6 0.843 Contact Map
5a63B 1 0.8 4.3 0.871 Contact Map
3w4tA 1 0.4571 4 0.874 Contact Map
4n6hA 1 1 3.3 0.878 Contact Map
3wt9A 1 0.8714 3.3 0.879 Contact Map
3rzeA 1 0.9429 3.2 0.88 Contact Map
2xq2A 2 0.7286 3 0.881 Contact Map
4z35A 1 0.9429 3 0.881 Contact Map
3dh4A 3 0.3571 2.9 0.882 Contact Map
3j8eG 3 0.8286 2.7 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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