GREMLIN Database
DUF4233 - Protein of unknown function (DUF4233)
PFAM: PF14017 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 104 (102)
Sequences: 3157 (2019)
Seq/√Len: 199.9
META: 0.768

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_L59_L3.3191.00
31_G35_G3.1821.00
72_F78_F3.1561.00
71_G78_F2.6731.00
11_E67_L2.5631.00
82_V86_A2.3681.00
89_V93_V2.2241.00
68_I85_A2.1961.00
47_L56_G2.1431.00
12_A45_V2.0891.00
35_G39_G2.0031.00
58_A62_V1.9711.00
55_W59_L1.9061.00
94_L97_R1.8641.00
58_A61_W1.7821.00
5_A48_A1.7721.00
90_Y94_L1.7591.00
4_C57_Y1.6741.00
13_I17_L1.6731.00
2_G6_A1.6431.00
95_G99_D1.6351.00
68_I81_G1.5951.00
34_L38_G1.5851.00
81_G85_A1.5291.00
32_T35_G1.5161.00
20_L24_G1.5091.00
55_W58_A1.5001.00
98_I101_R1.4361.00
17_L20_L1.4081.00
44_L63_L1.4031.00
78_F82_V1.3841.00
68_I78_F1.3801.00
9_I48_A1.3741.00
61_W89_V1.3631.00
51_L57_Y1.3591.00
50_L53_R1.3501.00
19_I37_G1.3321.00
86_A90_Y1.3241.00
50_L55_W1.3081.00
35_G38_G1.2721.00
15_V44_L1.2191.00
56_G59_L1.1641.00
34_L37_G1.1521.00
23_I26_G1.1261.00
98_I102_R1.1081.00
85_A89_V1.1061.00
61_W65_V1.0951.00
43_L47_L1.0911.00
48_A51_L1.0641.00
6_A10_L1.0561.00
94_L98_I1.0561.00
32_T36_V1.0361.00
47_L50_L1.0221.00
99_D102_R1.0221.00
20_L23_I0.9801.00
70_A77_M0.9700.99
71_G81_G0.9670.99
43_L63_L0.9560.99
38_G42_V0.9320.99
19_I41_A0.9240.99
4_C51_L0.9190.99
91_A98_I0.9090.99
22_A74_V0.8860.99
62_V66_A0.8650.99
54_P58_A0.8550.99
47_L63_L0.8480.99
21_V74_V0.8470.99
15_V67_L0.8390.98
79_V83_I0.8280.98
90_Y93_V0.8090.98
62_V65_V0.8050.98
4_C92_L0.7800.98
96_R100_R0.7740.97
49_G52_R0.7530.97
43_L59_L0.7520.97
72_F75_P0.7500.97
22_A25_L0.7490.97
46_L50_L0.7470.97
19_I34_L0.7450.97
16_L20_L0.7420.97
18_A80_L0.7290.96
71_G75_P0.7270.96
29_S32_T0.7250.96
9_I45_V0.7220.96
91_A95_G0.7220.96
37_G73_V0.7200.96
24_G27_D0.7170.96
75_P78_F0.7130.96
46_L49_G0.7110.96
30_P36_V0.7080.96
3_L6_A0.7000.95
1_R5_A0.6950.95
23_I30_P0.6770.95
33_A36_V0.6760.94
23_I27_D0.6720.94
3_L91_A0.6700.94
30_P34_L0.6700.94
6_A91_A0.6590.94
6_A9_I0.6510.93
56_G60_G0.6450.93
7_V91_A0.6450.93
93_V96_R0.6330.92
28_V33_A0.6240.92
59_L62_V0.6160.91
10_L13_I0.5980.90
67_L77_M0.5940.90
77_M80_L0.5920.90
40_L67_L0.5920.90
92_L95_G0.5860.89
14_V18_A0.5850.89
7_V87_L0.5840.89
57_Y92_L0.5840.89
15_V18_A0.5830.89
9_I13_I0.5830.89
68_I71_G0.5820.89
13_I16_L0.5810.89
18_A77_M0.5770.88
97_R100_R0.5770.88
92_L96_R0.5740.88
4_C60_G0.5600.87
41_A48_A0.5570.87
90_Y95_G0.5570.87
77_M81_G0.5570.87
44_L67_L0.5560.87
82_V85_A0.5560.87
84_F87_L0.5530.86
93_V97_R0.5520.86
33_A37_G0.5480.86
86_A89_V0.5470.86
15_V70_A0.5450.85
69_A75_P0.5440.85
66_A69_A0.5440.85
38_G45_V0.5430.85
51_L60_G0.5390.85
33_A38_G0.5350.84
4_C91_A0.5310.84
9_I18_A0.5270.83
61_W95_G0.5260.83
94_L101_R0.5250.83
31_G38_G0.5240.83
76_A80_L0.5240.83
11_E64_Q0.5240.83
36_V40_L0.5200.83
94_L102_R0.5150.82
69_A72_F0.5080.81
31_G36_V0.5060.81
29_S37_G0.5050.81
18_A70_A0.5040.81
41_A44_L0.5030.81
97_R101_R0.5020.80
90_Y102_R0.5010.80
31_G34_L0.5010.80
42_V49_G0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.3654 15.4 0.899 Contact Map
2kluA 1 0.4135 8.6 0.91 Contact Map
2l2tA 2 0.4231 5.8 0.916 Contact Map
4httA 1 0.6923 3.3 0.926 Contact Map
4b4aA 1 0.6923 2.5 0.931 Contact Map
2kncB 1 0.4615 2 0.934 Contact Map
1fftB 1 0.4615 1.9 0.935 Contact Map
2b2hA 3 0.9904 1.8 0.935 Contact Map
3pcvA 3 0.8846 1.8 0.936 Contact Map
4m5bA 1 0.375 1.5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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