GREMLIN Database
DUF4231 - Protein of unknown function (DUF4231)
PFAM: PF14015 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (99)
Sequences: 7669 (6266)
Seq/√Len: 629.8
META: 0.922

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_E97_Y4.5761.00
68_K71_E3.1141.00
81_E84_K2.8341.00
87_K91_L2.8081.00
14_Q18_K2.7001.00
95_G98_A2.3401.00
33_V55_A2.0021.00
12_R16_R1.8791.00
7_D80_A1.7511.00
7_D84_K1.7161.00
4_S8_R1.7041.00
22_L63_L1.6841.00
78_A82_A1.6731.00
21_R24_L1.6431.00
63_L67_F1.6131.00
24_L28_A1.5941.00
77_R81_E1.5871.00
88_W92_A1.5451.00
35_A50_T1.5211.00
9_K12_R1.5171.00
48_W52_V1.5151.00
80_A84_K1.4511.00
7_D11_R1.4371.00
89_L95_G1.4251.00
32_P35_A1.4041.00
36_A51_A1.3761.00
73_W77_R1.3431.00
3_I80_A1.3331.00
10_A14_Q1.3051.00
10_A77_R1.2871.00
24_L61_A1.2641.00
27_L53_L1.2521.00
20_L69_Y1.2401.00
50_T54_G1.2321.00
9_K76_Y1.2281.00
11_R15_R1.2091.00
14_Q17_Y1.1971.00
25_I62_G1.1711.00
21_R61_A1.1571.00
43_A47_A1.1561.00
70_Q74_I1.1291.00
16_R19_R1.1051.00
85_S89_L1.0981.00
51_A55_A1.0791.00
27_L60_L1.0701.00
33_V51_A1.0671.00
11_R14_Q1.0331.00
78_A85_S1.0301.00
61_A64_L1.0091.00
44_P47_A1.0001.00
6_Y79_T0.9921.00
88_W91_L0.9901.00
29_A59_I0.9881.00
23_I27_L0.9721.00
8_R12_R0.9701.00
72_N76_Y0.9611.00
16_R69_Y0.9571.00
20_L60_L0.9561.00
21_R64_L0.9541.00
21_R25_I0.9411.00
3_I7_D0.9391.00
31_I54_G0.9391.00
62_G66_L0.9201.00
86_E89_L0.9071.00
84_K88_W0.9001.00
5_W9_K0.8811.00
59_I63_L0.8771.00
19_R22_L0.8721.00
83_L87_K0.8701.00
5_W76_Y0.8661.00
41_G45_A0.8611.00
13_N72_N0.8601.00
31_I57_V0.8511.00
51_A54_G0.8381.00
13_N69_Y0.8341.00
39_L42_G0.8201.00
71_E75_R0.8161.00
38_L42_G0.7921.00
54_G58_A0.7701.00
15_R19_R0.7681.00
58_A61_A0.7661.00
10_A17_Y0.7621.00
89_L94_A0.7571.00
28_A57_V0.7511.00
43_A46_L0.7491.00
72_N75_R0.7391.00
48_W51_A0.7361.00
82_A85_S0.7271.00
10_A80_A0.7251.00
98_A101_D0.7201.00
13_N76_Y0.7171.00
3_I6_Y0.7081.00
8_R11_R0.7081.00
42_G47_A0.6991.00
77_R84_K0.6941.00
54_G57_V0.6871.00
40_G43_A0.6811.00
22_L26_V0.6771.00
32_P58_A0.6711.00
7_D77_R0.6681.00
75_R79_T0.6681.00
73_W81_E0.6671.00
89_L96_P0.6651.00
17_Y70_Q0.6631.00
47_A51_A0.6621.00
21_R65_Q0.6591.00
4_S7_D0.6491.00
52_V55_A0.6481.00
39_L44_P0.6441.00
22_L67_F0.6431.00
20_L64_L0.6421.00
24_L60_L0.6401.00
7_D14_Q0.6391.00
34_L53_L0.6351.00
63_L66_L0.6331.00
64_L70_Q0.6281.00
31_I53_L0.6271.00
63_L69_Y0.6111.00
37_S41_G0.5981.00
47_A50_T0.5971.00
24_L29_A0.5961.00
31_I35_A0.5951.00
13_N17_Y0.5891.00
61_A65_Q0.5871.00
39_L43_A0.5851.00
42_G45_A0.5841.00
16_R20_L0.5801.00
34_L46_L0.5801.00
32_P36_A0.5761.00
77_R80_A0.5731.00
46_L50_T0.5711.00
28_A32_P0.5701.00
27_L56_L0.5691.00
44_P48_W0.5681.00
35_A54_G0.5651.00
24_L27_L0.5561.00
45_A48_W0.5541.00
65_Q70_Q0.5491.00
58_A62_G0.5441.00
17_Y64_L0.5410.99
64_L69_Y0.5370.99
17_Y66_L0.5300.99
7_D10_A0.5200.99
65_Q68_K0.5190.99
69_Y72_N0.5160.99
6_Y10_A0.5150.99
59_I62_G0.5090.99
25_I31_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.6857 23.8 0.85 Contact Map
2m8rA 1 0.381 21.4 0.853 Contact Map
4i0uA 4 0.6667 20.4 0.855 Contact Map
3sokA 1 0.619 10.7 0.872 Contact Map
2j5uA 4 0.2667 8.3 0.878 Contact Map
2hi2A 1 0.5905 7.8 0.88 Contact Map
2m7gA 1 0.5619 6.3 0.884 Contact Map
1oqwA 1 0.6 5.5 0.888 Contact Map
3j01B 1 0.7429 3.9 0.896 Contact Map
4q4hB 1 0.9905 3.8 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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