GREMLIN Database
DUF4229 - Protein of unknown function (DUF4229)
PFAM: PF14012 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (61)
Sequences: 3612 (2111)
Seq/√Len: 270.3
META: 0.796

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_L49_L2.8921.00
51_R55_D2.7951.00
6_L53_Q2.6551.00
14_L41_I2.2191.00
62_A66_E2.0971.00
19_W34_A1.9201.00
18_L37_L1.7281.00
53_Q56_A1.7231.00
11_F39_L1.6841.00
52_R56_A1.6451.00
14_L45_L1.6031.00
2_V56_A1.5751.00
10_L45_L1.5731.00
11_F42_S1.5111.00
37_L41_I1.4951.00
58_A62_A1.4551.00
61_L65_A1.4231.00
59_A63_A1.3841.00
18_L41_I1.2741.00
55_D59_A1.2701.00
44_P48_V1.2641.00
16_A20_L1.2131.00
63_A66_E1.1841.00
15_L34_A1.1641.00
29_V37_L1.1531.00
55_D58_A1.0991.00
18_L22_G1.0691.00
15_L38_A1.0671.00
2_V5_L1.0591.00
15_L35_L1.0571.00
16_A19_W1.0301.00
9_G14_L1.0131.00
2_V6_L0.9921.00
29_V33_L0.9771.00
33_L36_L0.9451.00
19_W22_G0.9161.00
35_L39_L0.9131.00
17_V20_L0.9041.00
32_L36_L0.8971.00
15_L19_W0.8771.00
36_L39_L0.8681.00
39_L43_G0.8551.00
11_F15_L0.8541.00
55_D62_A0.8411.00
59_A62_A0.8361.00
43_G47_Y0.8350.99
57_M60_A0.8300.99
42_S57_M0.8220.99
22_G34_A0.8210.99
56_A59_A0.8200.99
22_G29_V0.7990.99
15_L31_G0.7900.99
53_Q57_M0.7820.99
14_L18_L0.7670.99
18_L34_A0.7600.99
8_L12_A0.7600.99
53_Q60_A0.7410.99
6_L50_L0.7350.99
5_L9_G0.7110.98
42_S46_S0.7090.98
15_L30_P0.7010.98
34_A38_A0.6970.98
51_R57_M0.6920.98
4_T64_R0.6910.98
13_V17_V0.6880.98
40_V44_P0.6750.98
32_L42_S0.6640.97
19_W31_G0.6530.97
50_L58_A0.6470.97
35_L42_S0.6450.97
41_I45_L0.6390.97
3_Y7_R0.6260.96
15_L22_G0.6250.96
58_A64_R0.6180.96
19_W30_P0.6170.96
1_L4_T0.6170.96
17_V21_L0.6170.96
6_L9_G0.6130.96
63_A67_R0.6020.96
58_A61_L0.5750.94
9_G16_A0.5640.94
10_L49_L0.5580.93
2_V53_Q0.5520.93
39_L44_P0.5510.93
33_L37_L0.5410.92
64_R67_R0.5390.92
60_A64_R0.5370.92
62_A65_A0.5360.92
43_G48_V0.5350.92
18_L29_V0.5200.91
30_P34_A0.5150.90
57_M65_A0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pypA 1 0.7353 9.4 0.843 Contact Map
4ldsA 2 0.7794 8.9 0.844 Contact Map
4zw9A 1 0.9559 7.4 0.85 Contact Map
4j05A 3 0.9412 7 0.852 Contact Map
4ry2A 2 0.9118 6.8 0.853 Contact Map
1pw4A 1 0.9412 6.5 0.854 Contact Map
4ikvA 1 0.8088 6 0.857 Contact Map
4tphA 2 0.8382 5 0.862 Contact Map
4q4hA 1 0.8824 4.9 0.862 Contact Map
3c75L 1 0 4.2 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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