GREMLIN Database
RSN1_TM - Late exocytosis, associated with Golgi transport
PFAM: PF13967 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (154)
Sequences: 2403 (1784)
Seq/√Len: 143.8
META: 0.217

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_N138_H7.6851.00
88_I149_V4.8711.00
51_G54_G3.6181.00
106_T134_R3.4731.00
103_V137_A2.9221.00
57_P61_R2.7101.00
96_S145_F2.6201.00
151_Y155_R2.4741.00
134_R137_A2.4681.00
91_V148_W2.4621.00
97_L101_L2.3031.00
64_E76_Y2.1161.00
146_T150_C2.0231.00
40_E43_R1.9981.00
44_T47_L1.9801.00
15_V19_L1.8971.00
95_L141_F1.8971.00
68_L76_Y1.8921.00
94_L98_P1.8741.00
99_I141_F1.8491.00
86_L90_L1.8411.00
63_S66_E1.8231.00
148_W152_L1.8161.00
147_G151_Y1.8021.00
139_V143_Y1.7111.00
143_Y147_G1.6861.00
19_L23_L1.5861.00
48_P51_G1.5551.00
101_L123_L1.5471.00
96_S141_F1.5051.00
84_M152_L1.4991.00
98_P102_P1.4791.00
99_I102_P1.4351.00
92_I145_F1.4211.00
55_W74_D1.3721.00
11_V14_L1.3661.00
66_E69_Q1.3531.00
67_L79_L1.3341.00
27_N30_V1.3141.00
112_D117_D1.3091.00
114_D117_D1.2871.00
67_L76_Y1.2691.00
100_L104_N1.2321.00
41_S47_L1.2311.00
7_V11_V1.2291.00
87_K155_R1.2191.00
113_D117_D1.2171.00
143_Y146_T1.1871.00
62_T66_E1.1861.00
101_L105_A1.1811.00
123_L126_S1.1290.99
82_L120_L1.1250.99
109_G112_D1.1180.99
11_V15_V1.0970.99
63_S69_Q1.0870.99
112_D115_D1.0860.99
123_L127_N1.0840.99
25_P34_R1.0770.99
95_L144_L1.0760.99
44_T48_P1.0660.99
107_G127_N1.0600.99
136_W140_V1.0370.99
91_V152_L1.0350.99
120_L123_L1.0270.99
85_L89_F1.0200.99
119_G123_L1.0120.99
42_E45_P1.0110.99
67_L71_A0.9980.99
59_L78_F0.9880.98
13_F16_L0.9880.98
27_N31_Y0.9860.98
94_L133_N0.9750.98
87_K152_L0.9720.98
100_L137_A0.9480.98
97_L105_A0.9380.98
12_I15_V0.9380.98
123_L139_V0.9290.98
125_I135_L0.9280.98
44_T49_S0.9200.98
113_D116_D0.9180.97
119_G128_V0.9140.97
133_N136_W0.9130.97
7_V10_L0.9100.97
28_P32_A0.9010.97
19_L22_I0.8930.97
112_D116_D0.8930.97
108_G111_D0.8910.97
140_V144_L0.8910.97
9_N12_I0.8890.97
95_L98_P0.8820.97
99_I103_V0.8730.97
84_M88_I0.8720.97
92_I96_S0.8710.97
141_F145_F0.8700.97
17_L21_S0.8690.96
9_N30_V0.8650.96
87_K151_Y0.8600.96
136_W139_V0.8570.96
89_F92_I0.8540.96
4_T8_I0.8450.96
42_E47_L0.8430.96
14_L133_N0.8340.96
33_P36_Y0.8290.95
107_G112_D0.8260.95
18_L22_I0.8260.95
110_G113_D0.8230.95
5_S8_I0.8210.95
25_P32_A0.8120.95
34_R148_W0.8020.95
77_V81_F0.7940.94
139_V146_T0.7880.94
25_P139_V0.7820.94
77_V146_T0.7760.94
41_S44_T0.7720.93
99_I140_V0.7710.93
29_R36_Y0.7680.93
4_T75_A0.7680.93
88_I91_V0.7670.93
105_A123_L0.7530.92
124_T127_N0.7520.92
93_A97_L0.7490.92
6_L118_S0.7490.92
139_V150_C0.7480.92
42_E69_Q0.7430.92
51_G58_P0.7420.92
12_I16_L0.7360.92
5_S9_N0.7320.91
64_E68_L0.7320.91
71_A77_V0.7280.91
14_L57_P0.7270.91
9_N13_F0.7240.91
10_L14_L0.7190.91
39_G42_E0.7190.91
68_L73_L0.7180.91
109_G113_D0.7170.91
76_Y81_F0.7140.90
90_L94_L0.7140.90
100_L138_H0.7100.90
107_G135_L0.7080.90
21_S53_F0.7080.90
106_T113_D0.6960.89
86_L89_F0.6950.89
56_I60_L0.6950.89
21_S52_F0.6950.89
40_E65_E0.6900.89
21_S25_P0.6900.89
88_I92_I0.6900.89
89_F93_A0.6900.89
88_I148_W0.6870.89
5_S16_L0.6850.88
64_E83_R0.6850.88
87_K136_W0.6820.88
22_I25_P0.6770.88
2_F6_L0.6750.88
73_L85_L0.6750.88
9_N16_L0.6730.88
77_V86_L0.6700.87
82_L100_L0.6680.87
8_I48_P0.6640.87
43_R70_H0.6590.86
3_L7_V0.6560.86
31_Y73_L0.6540.86
43_R56_I0.6490.86
90_L148_W0.6460.85
47_L51_G0.6400.85
111_D115_D0.6350.84
43_R90_L0.6300.84
59_L72_G0.6270.84
47_L50_K0.6270.84
4_T10_L0.6250.83
11_V40_E0.6240.83
18_L54_G0.6150.82
23_L27_N0.6130.82
146_T153_L0.6120.82
2_F120_L0.6090.82
53_F57_P0.6080.82
121_D134_R0.6070.82
90_L105_A0.6070.82
101_L104_N0.6050.81
98_P106_T0.6030.81
3_L6_L0.6020.81
80_R120_L0.6020.81
24_R145_F0.6020.81
105_A122_R0.6020.81
17_L138_H0.6000.81
58_P73_L0.5980.81
142_A146_T0.5940.80
40_E44_T0.5940.80
5_S26_R0.5880.80
24_R92_I0.5860.79
62_T70_H0.5840.79
43_R47_L0.5820.79
29_R38_K0.5820.79
89_F139_V0.5780.78
133_N140_V0.5770.78
118_S128_V0.5740.78
21_S55_W0.5710.78
60_L93_A0.5690.77
72_G75_A0.5690.77
107_G129_P0.5650.77
49_S54_G0.5640.77
107_G111_D0.5600.76
73_L80_R0.5600.76
92_I149_V0.5500.75
6_L124_T0.5500.75
147_G150_C0.5460.74
125_I138_H0.5460.74
80_R84_M0.5440.74
110_G128_V0.5430.74
4_T136_W0.5390.73
71_A79_L0.5390.73
31_Y72_G0.5380.73
45_P49_S0.5370.73
59_L75_A0.5360.73
66_E70_H0.5340.73
14_L151_Y0.5330.73
2_F5_S0.5240.71
10_L112_D0.5240.71
31_Y34_R0.5230.71
81_F102_P0.5210.71
16_L146_T0.5210.71
116_D130_T0.5160.70
28_P36_Y0.5140.70
78_F89_F0.5120.70
131_G144_L0.5050.69
122_R127_N0.5050.69
35_T84_M0.5050.69
13_F26_R0.5040.68
110_G115_D0.5030.68
41_S46_P0.5030.68
108_G113_D0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4um9B 2 0 7.5 0.932 Contact Map
2m20A 2 0.3526 5.2 0.937 Contact Map
1pfiA 7 0.1667 4.2 0.94 Contact Map
4aw6A 2 0.9615 4.2 0.94 Contact Map
2ww9B 1 0.3654 3.9 0.941 Contact Map
4ryoA 1 0.4231 3.7 0.941 Contact Map
3ug9A 2 0.3782 3.6 0.942 Contact Map
2k1kA 2 0.1795 3.4 0.942 Contact Map
2jafA 3 0.2115 3.2 0.943 Contact Map
1v54A 1 0.391 2.6 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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